Excipients

Question 1

What are Diluents (Bulking agents)?

Answer 1

inert substance added to make a reasonable sized tablet or increase weight and improve content uniformly i.e lactose, micro crystalline cellulose (MCC), starches.

Question 2

What are lubricants?

Answer 2

necessary to prevent adherence of the formulation to punches and dies. they ensure smooth ejection of the tablet from the die. for example, Steraic acid, magnesium stearate.

Question 3

What are the role of glidants (flow agents)?

Answer 3

materials which are added to tablet formulations in order to improve the flow properties of granules, by reducing inter particulate friction. i.e, fumed silica, asynthetic amorphous colloidal silicon dioxide

Question 4

What are disintegrates?

Answer 4

added to tablets to promote breakup of tablets in vivo, so the active ingredient is rapidly released to increase a surface area, it disintegrates and deaggregates to promote rapid release of drug. I,e starch, PVP, cellulose