Drug solubility and dissolution rate 1 and 2

Question 1

SOLUTION definition?

Answer 1

a mixture of two or more components that forms a single phase which is homogeneous down to the molecular level

Question 2

saturated solution?

Answer 2

solute is in equilibrium with the solid phase

Question 3

unsaturated solution

Answer 3

the dissolved solute is in conc below that necessary for complete saturation at a definite temperature

Question 4

What is dissolution?

Answer 4

for a drug to be absorbed, it must first be dissolved in the fluid at the site of absorption.

Question 5

How can dissolution rate be raised?

Answer 5

increasing the surface area of the drug by reducing the particle size
increasing drug solubility in diffusing layer
increasing K

Question 6

Factors affecting dissolution rate?

Answer 6

SURFACE AREA
solubility in the dissolution medium
thickness of boundary layer
Diffusion coefficient

Question 7

How does reduction in particle size increase dissolution rate?

Answer 7

By increasing exposure amounts of solute to the solvent

Question 8

what are cyclodextrins?

Answer 8

products that result from the incorporation of the non polar portion of one molecule into the non polar cavity of another molecule that is water soluble