example questions Flashcards
Which demographic is most affected by leukoedema?
- asymptomatic gray-white lesion on the buccal/labial mucosa *
Smokers and pts of African origin.
What is the haematocrit?
Ratio of RBCs to all blood cells (usually given as a %).
Define Mean Corpuscular Volume.
Measures the average size and volume of a RBC to help determine the aetiology of anaemia.
(think, the mean is the AVERAGE)
What are haematinics?
Nutrients required by the body for erythropoiesis (making RBCs).
e.g: iron needed for haemoglobin synthesis.
Folate deficiency is a deficiency in which vitamin?
B12 - because humans can’t make it.
What is ESR?
Erythrocyte Sedimentation Rate - rate at which RBCs in anticoagulated blood descend in a standardised tube over an hour.
- NON-SPECIFIC MEASURE OF INFLAMMATION *
>35mm/hour should raise suspicion.
In terms of plasma glucose level, diabetes is defined as…
A single random plasma glucose level of >11.1mmol/L or fasting sample of >7.0
What HbA1c level is indicative of diabetes?
> 40mmol/L
What is hairy tongue and how can it be caused?
Elongation of filiform papillae and accumulation of epithelial squames/extrinsic staining.
Can be caused by:
- xerostomic drugs (antibiotics)
- chlorhexidine
- corticosteroids
When diagnosing RAS, which 4 conditions must we consider and exclude?
- Hematinic Deficiency - deficiency of nutrients essential for RBC formation.
- Coeliac Disease - immune system attacks tissues when eating gluten.
- Bechet’s - disorder causing blood vessel inflammation.
- HIV
What sites are the 3 types of RAS most commonly found on?
Minor RAS - non-keratinised mucosa (labial/buccal mucosa, lateral border of tongue).
Major RAS - all mucosa.
Herpetiform - non-keratinised mucosa.
Which 2 types of oral lichen planus is considered to be potentially malignant?
Atrophic Oral Lichen Planus
Erosive Oral Lichen Planus
Which type of medication is Azathioprine?
Immunosuppressant
(used to treat rheumatoid arthritis, chron’s, systemic lupus erythematous)
What is the most common variant of oral lichen planus?
Reticular (erosive = second most common).
What is pyostomatitis vegetans?
Associated with inflammatory bowel disease so management of this condition may see symptoms improve.
(all pts presenting with this should be investigated for bowel disease).
What type of inheritance pattern is seen in Peutz-Jegher Syndrome?
Autosomal Dominant
(PJS - polyps form in the intestines).
What type of inheritance pattern is seen in Gardner’s Syndrome?
Autosomal Dominant
(development of hundreds of polyps in the small and large intestines).
Which demographics are most affected by pemphigus vulgaris?
Jewish, Asian or Mediterranean origin with a strong genetic background.
(rare group of autoimmune diseases causing skin/mucous membrane blisters)
What are the target antigens of pemphigus vulgaris?
Desmoglein 1 and 3
(just DSG3 = mucosal, both present = mucocutaneous)