Exam Two Flashcards
What are the three main parts to the lymphatic system?
Lymphatic vessels
Lymph
Lymph nodes
How does the lymphatic system help maintain homeostasis?
Returns fluid that has leaked from the blood vascular system back to the blood
Filtration
Immune system activation
What is the function of lymphatic vessels?
Forms a one way system that takes fluid that has leaked from capillaries back to venous system
What is lymph movement dependent on?
Skeletal muscle contraction
What is lymph?
Fluid in lymphatic vessels
Consists of water, electrolytes, proteins and waste
What is the specialized lymph that picks up fat?
Lactile
Found in the intestinal mucosa
What is the one location where lymph is thicker?
Intestines
What is the main function of lymph nodes?
Filters lymph
Activates the immune system
How does lymph go through lymph nodes?
Lymph enters through many afferent lymphatic vessels
Can only leave through two efferent vessels
What is the reasoning for having more afferent vessels than efferent vessels?
Causes the flow to be slow so filtration can occur
What are the main immunocompetent cells?
B cells
T cells
What is the function of B cells?
Produce plasma cells that produce antibodeis
What is the function of T cells?
Directly attack infected cells
Where do B cells mature?
Red bone marrow
Where do T cells mature?
Thymus gland
What is the function of the spleen?
Filters the blood
What are the two regions of the spleen?
Red pulp - where filtration occurs
White pulp - contains lymphocytes
What are the secondary lymphoid organs?
Spleen Thymus Tonsils MALT Peyer's Patches Appendix
What are the four types of tonsils?
Palantine
lingual
Pharyngeal
Tubal
Where are palantine tonsils located?
Back of the throat
Where are lingual tonsils located?
Base of the tongue
Where are pharyngeal tonsils located?
Posterior wall of nasopharynx
Often called adnoids
Where are tubal tonsils located?
Opening of the auditory tube
What is the function of tonsils?
Binds to and kills bacteria
Where are peyer’s patches located?
Throughout the distal wall of the small intestine
What is the function of peyer’s patches?
Attempts to kill bacteria before it breaches the intestine wall
What is MALT?
Mucosa Associated Lymphatic Tissue
Protects openings to the outside world
What is lymphoid tissue largely composed of?
Reticular connective tissue
What are medullary cords?
Thin inward extensions from the cortical lymphoid tissue
What are lymph sinuses?
Large lymph capillaries spanned by crisscrossing reticular fibers
What is the order of structures that lymph goes through in lymph nodes?
Afferent lymphatic vessels Subcapsular sinus Medullary sinuses Efferent lymphatic vessels Hilum
What are the two lymphatic ducts?
Right lymphatic duct
Thoracic duct
What is the function of the appendix?
Destroy pathogens before they can breach the intestinal wall
Generate many memory lymphocytes for long term immunity
What are the two types of immunity?
Innate immunity
Adaptive immunity
What is innate immunity?
Immunity that we are born with
Quick responding, nonspecific immunity
What are the four components to innate immunity?
Physical and chemical barriers
Inflammation
Phagocytes and natural killer cells
Protective proteins
What are the physical barriers of the innate immune system?
Skin and mucous membranes
What are the chemical barriers of the innate immune system?
Stomach is highly acidic
Oil glands in skin secrete chemicals
Normal bacteria in intestine attack foreign bacteria
What is the purpose of inflammation?
Brings extra blood to damaged tissue
Blood contains nutrients, platelets, neutrophils and monocytes
What are the four signs of inflammation?
Redness
Heat
Swelling
Pain
What cell types are phagocytes?
Neutrophils - first to arrive, forms puss
Monocytes/macrophage - Release cytokines
What are natural killer cells?
Destroy foreign cells with cell to cell contact
Do not recognize specific antigens
What is the function of interferons?
Infected cells release interferon which helps protect cells that have yet to be infected
What is adaptive immunity?
Specific defensive system
Has a memory
Attacks particular foreign substances
What are the cell types involved in adaptive immunity?
B cells
T cells
What is the function of B cells in adaptive immunity?
Give rise to plasma cells with produce antibodies
Antibodies combine with and neutralize particular antigens
What are the two types of T cells in the adaptive immunity?
Helper T cells
Cytotoxic cells
What is the function of helper t cells?
Release chemicals to regulate immune system
What is the function of cytotoxic cells?
Attack and kill virus infected or tumor cells
What is active humoral immunity?
When your B cells encounter antigens and produce antibodies against them
How is active immunity acquired?
Naturally acquired - get a bacterial or viral infection
Artificially acquired - from vaccines
What is passive humoral immunity?
Ready made antibodies are introduced into your body
B cells do not respond to antigens in this case
Borrowed antibodies
How is passive immunity acquired?
Naturally - babies/fetuses receive antibodies from their mothers or mother’s milk
Artificially - Antibodies are injected into your body (antivenom)
What are cytokines?
Small proteins that act as chemical messengers between various parts of the immune system
What is pulmonary ventilation?
Movement of air into and out of the lungs
What is external respiration?
O2 and CO2 exchange between lungs and blood
What is transport in the respiratory system?
O2 and CO2 are transported in the blood
What is internal respiration?
O2 and CO2 exchange between systemic blood vessels and tissues
What are the two major tracts in the respiratory system?
Upper respiratory tract
Lower respiratory tract
What is included in the upper respiratory tract?
Nose
Pharynx
Larynx
What is included in the lower respiratory tract?
Starts at trachea
Bronchi and all branches
Lungs and alveoli
What are the different respiratory zones?
Conducting zone
Respiratory zone
What is the function of the respiratory zone?
Actual site of gas exchange
External respiration
What is included in the respiratory zone?
Respiratory bronchioles and alveoli
What are the functions of the conducting zone?
Cleans, warms and humidifies incoming air
Tracheal cartilage provides protection from airway collapse
Smooth muscle in terminal bronchiole allows for alveoli protection
What does the conducting zone include?
Nose and nasal passages Pharynx Larynx Trachea Bronchi Terminal bronchioles
What is the function of the glattis?
Helps create vibrations
What is the slit between the vocal and vestibular folds called?
Glattis
What are the three layers of the respiratory membrane?
Alveolar wall
Interstitial space
Capillary wall
What kind of cells is the alveolar wall made of?
Type 1 alveolar cells (95%)
Some cuboidal type 2 alveolar cells
What kind of cells is the capillary wall made of?
Single cell layer thick
What is the function of surfactant?
Prevents collapse of alveoli
What is the function of alveoli pores?
Connect adjacent alveoli
Equalize air pressure throughout lungs
What are the layers of the pleurae?
Parietal plurae
Pleural cavity
Visceral plurae
What is the function of plurae fluid?
Reduces friction for lungs as they glide over thorax wall during breathing movements
What is intrapulmonary pressure?
The pressure in the alveoli
Always equalizes with atmospheric pressure eventually
What is intrpleural pressure?
Pressure in the pleural cavity
Always about 4mm Hg than intrapulmonary pressure
What is transpulmonary pressure?
The difference between the intrapulmonary and intrapleural pressure
What happens if transpulmonary pressure equals zero?
Immediate lung collapse
What muscles are involved in quiet inspiration?
Diaphragm and external intercoastals
What muscles are involved in vigorous inspiration?
Scalenes
Sternocleidomastoid
Pectoralis minor
Erector spinae
What muscles are involved in quiet expiration?
Depends more on lung elasticity than muscle contraction
What muscles are involved in vigorous expiration?
Abdominal wall muscles
Oblique and transversus muscles