Exam II: Respiratory System (Functions and Conducting Portion) Flashcards

1
Q

Functions of the Respiratory system

A
  • Oxygen and CO2 exchange
  • Olfaction
  • Phonation
  • Provide defense
  • Condition air
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2
Q

Examples of objects filtered in the large, medium, and small particle filters of the respiratory system

A

Large- bugs
Medium- dust and pollen
Small- bacteria and viruses

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3
Q

Part of nasal cavity. Surface epithelium is keratinized stratified squamous, sebaceous and sweat glands are present, supported by hyaline cartilage, and contains a large particle filter.

A

Vestibule

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4
Q

What acts as the large particle filter in the nasal vestibule?

A

Vibrissae

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5
Q

Where is the respiratory region of the nasal cavity located?

A

Between the limen nasi and superior and middle concha

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6
Q

Functions of the respiratory region

A
  • Warm air
  • Clean air
  • Humidify air
  • Provide defense
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7
Q

Part of the nasal cavity. Surface epithelium is respiratory (ciliated pseudostratified columnar). Contains the medium particle filter.

A

Respiratory Region

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8
Q

What makes up the Mucociliary Apparatus? What is the function of this structure?

A

Goblet and Ciliated Columnar cells

-Both function to act as the medium particle filter.

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9
Q

Glands of the respiratory region are found in this layer

A

Lamina propria (LP)

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10
Q

Type of gland found in the respiratory region

A

Seromucus glands

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11
Q

Functions of Seromucus glands

A
  • Produces mucus for mucociliary clearance and air humidity (mucus portion)
  • Produces serous products like lysozymes, inferferons, and cytokines. Also air humidity. (Serous portion)
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12
Q

This structure is also located in the Lamina propria (LP). It has many large venules that are typically partially filled.

A

Cavernous plexus

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13
Q

Functions of the Cavernous plexus

A
  • Warm air
  • Humidify air
  • Provide defense (inflammation)
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14
Q

How does the cavernous plexus contribute to having a stuffy nose?

A

As blood volume increases, the venules enlarge and the lamina propria increases in size as the lumen size decreases resulting in a stuffy nose.

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15
Q

Hoe does the cavernous plexus contribute to having a running nose?

A

As blood volume increases, Oxygen uptake increases which will stimulate seromucus gland secretion, resulting in a runny nose.

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16
Q

What tissues support the Respiratory region?

A

Hyaline cartilage and bone

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17
Q

Part of the nasal cavity. Surface epithelium is olfactory epithelium with supporting and basal cells and olfactory neurons.

A

Olfactory region

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18
Q

What do supporting cells do in the Olfactory region of the nasal cavity?

A

Provide physical support, nourishment, and electrical insulation for the olfactory cells.

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19
Q

T/F Support cells are simple cuboidal cells

A

FALSE.

They are columnar cells with microvilli

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20
Q

Bipolar neurons with olfactory cilia extending onto the epithelial surface

A

Olfactory neurons

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21
Q

What does the basal axon of the olfactory neuron connect to?

A

Olfactory bulb

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22
Q

Cells that are small pyramidal shaped cells that can divide and replace the other cell types in the olfactory region

A

Basal cells

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23
Q

This gland is found in the olfactory region and produces a serous product to cleanse olfactory cilia

A

Olfactory (Bowman’s) Glands

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24
Q

Support tissue of the olfactory region

A

Bone

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25
Q

Found in the ethmoid, sphenoid, frontal, and maxilla bones. Connected to the nasal cavity through openings

A

Paranasal sinuses

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26
Q

Paranasal sinuses are connected to the nasal cavity through:

A

Sinal ostia

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27
Q

Epithelium is respiratory epithelium. Lamina propria is thin, but has seromucus glands and is quite vascular.

A

Paranasal sinuses

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28
Q

Possible problem associated with the paranasal sinuses

A

Small ostia, but large vascular lamina propria. Lamina propria can swell and clog the ostia, not allowing the sinuses to drain appropriately

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29
Q

Divisions of the pharynx from superior to inferior

A

Nasopharynx (superior)
Oropharynx (middle)
Laryngopharynx (inferior)

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30
Q

Surface epithelium of the Nasopharynx

A

Respiratory epithelium with mucociliary clearance

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31
Q

Surface epithelium of the Oropharynx and Laryngopharynx

A

Stratified squamous

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32
Q

Tonsils associated with the different divisions of the Pharynx

A
Nasopharynx = pharyngeal tonsils 
Oropharynx = Palatine and lingual tonsils 
Laryngopharynx = NO tonsils present
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33
Q

T/F The muscularis mucosa of the pharynx is large and quite vascular

A

FALSE.

The muscularis mucosa is NOT present in the pharynx

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34
Q

Part of pharynx. Consists of collagen in periosteum of basilar portion of occiput blending into the wall of the pharynx. Functions in added support to the pharynx

A

Submucosa

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35
Q

Alternative name for the submucosa of the pharynx

A

Pharyngobasilar Fascia

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36
Q

Type of muscle found in the pharynx

A

Skeletal muscle

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37
Q

T/F The muscular pattern of the pharynx in the same as the muscular pattern of the G.I. tract

A

FALSE.
Pharynx(inner longitudinal, outer circular layer) has an opposite arrangement than the G.I. tract (outer longitduinal, inner circular layers)

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38
Q

Besides the muscularis externa of the pharynx, where else in the body is the arrangement of the muscular externa opposite of the G.I. tract.

A

Uterus

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39
Q

Part of pharynx. Consists of the epimysium of the buccinator muscle blending into the pharynx.

A

Adventitia

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40
Q

Alternative name for the adventitia of the pharynx

A

Buccopharyngeal Fascia

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41
Q

Organ that lies between the pharynx and the trachea

A

Larynx

42
Q

Surface epithelium of the Larynx

A

Upper surface is stratified squamous (parts will transition to respiratory)

43
Q

Functions of the cartilage wall in the larynx

A
  • Maintains an open airway

- Aid in sound production (in addition to skeletal wall)

44
Q

T/F Lamina propria of the larynx consists of dense connective tissue with no seromucus glands

A

FALSE.

LP on larynx consists of LOOSE connective tissue WITH seromucus glands

45
Q

Type of cartilage found in the larynx. Structures consisting of it include: thyroid, cricoid, and inferior arytenoid cartilages

A

Hyaline cartilage

46
Q

Type of cartilage found in the larynx. Structures consisting of it include: epiglottis, cuneiform, corniculate, and superior arytenoid cartilages

A

Elastic cartilage

47
Q

General function of the epiglottis

A

To keep food and liquid out of the larynx

48
Q

Immovable folds of tissue below the epiglottis. Surface epithelium is respiratory epithelium and lamina propria is loose connective tissue with seromucus glands and possible lymph nodules.

A

Vestibular folds

49
Q

Surface epithelium of the laryngeal ventricle

A

Stratified squamous

50
Q

Found below the epiglottis. Surface epithelium is stratified squamous, lamina propria has dense regular bundles of elastic connective tissue, and contains a muscle.

A

Vocal folds (cords)

51
Q

Function of the surface epithelium of the Vocal folds (cords)

A

Protect from abrasion and to some degree drying of tissues due to rapid air movement.

52
Q

Function of the lamina propria of the Vocal folds (cords)

A

Supports vocal folds

53
Q

Striated muscle located deep to the mucosa of the Vocal folds. Helps create sound by allowing air to vibrate against the vocal folds.

A

Vocalis

54
Q

Part of Trachea. Surface epithelium is respiratory epithelium that contains many different cell types within it. Lamina propria is loose connective tissue with seromucus glands and is quite vascular.

A

Mucosa

55
Q

T/F The smallest part of the Trachea is the muscularis mucosa

A

FALSE.

The muscularis mucosa is absent in the trachea

56
Q

Breakdown of cell types in the mucosa of the trachea

A
Goblet cells- 30%
Ciliated columnar cells- 30%
Basal cells- 30%
Brush cells- 3%
Serous cells- 3%
DNES (Small Granule)(Kulchitsky) cells- 3-4%
57
Q

Hypothetical function of Brush cells in the mucosa of the trachea

A

Chemosensory (monitors air quality?)

58
Q

Function of Serous cells of the mucosa of the trachea

A

Secretion of a product into lumen (product is unknown)

59
Q

Function of DNES (Small Granule)(Kulchitsky) cells

A

Secrete into the Lamina propria, so likely influence over other cells in respiratory epithelium.

60
Q

The submucosa of the trachea contains a ________________ ring that blends with the lamina propria

A

Hyaline cartilage

61
Q

T/F General rule: Vertical running organs usually have serosa

A

FALSE.

Vertical running organs usually have adventitia

62
Q

Structurally similar to the trachea. Includes primary bronchi and has structural trends.

A

Extrapulmonary Bronchi

63
Q

Structural trends that decrease in the Bronchi (TQ)

A
  • Amount of cartilage
  • Number of glands (in lamina propria)
  • Number of goblet cells
  • Height of the Epithelium
64
Q

Structural trends that increase in the Bronchi (TQ)

A
  • Smooth muscle (Trachealis) increases as we get to bronchi

- Elastic connective tissue (helps with recoil during respiration)

65
Q

Similiar to extrapulmonary bronchi. Includes secondary and tertiary bronchi.Trends of extrapulmonary bronchi are continued through this structure

A

Intrapulmonary Bronchi

66
Q

Structures that have no hyaline cartilage, no seromucus glands, and have a complete smooth muscle layer

A

Bronchioles

67
Q

Epithelium type of the Bronchioles

A

Ciliated simple columnar/cuboidal with some goblets and special cells. (can vary along the length)

68
Q

Secretory cells in the surface epithelium of bronchioles.

A

Clara cells

69
Q

Functions of Clara cells

A
  • Secrete product to protect epithelium
  • Produce enzymes which degrade toxins
  • Regenerate bronchiolar epithelium
  • Secrete lysozyme
  • Produce a surfactant type of molecule
70
Q

Last part of the conducting portion of the respiratory system. Epithelium is simple columnar/cuboidal often ciliated and has Clara cells. Has a fibroelastic connective tissue in its lamina propria. Also contains 1-2 layers of smooth muscles

A

Terminal bronchioles

71
Q

First region of respiratory portion of respiratory system

A

Respiratory Bronchioles

72
Q

Structure is simple cuboidal epithelium with Clara cells and some cilia. Structure is similar to terminal brochioles, but also contains some simple squamous epithelium

A

Respiratory bronchioles

73
Q

T/F Gas exchange does not occur in the Respiratory bronchioles

A

FALSE.

It contains some simple squamous epithelium, therefore gas exchange is possible

74
Q

General function of alveolar ducts, alveolar sac, and alveoli

A

Gas exchange

75
Q

Cell type of alveoli. Covers ~95% of alveolar surface. Consists of squamous type cells with zonula occludens between cells. Function is gas exchange.

A

Alveolar Type I (Type I Pneumocyte)

76
Q

Cell type of alveoli. Found most to the side between alveoli. Consists of cuboidal cells and has 3 general functions.

A

Alveolar Type II (Type II Pneumocyte)

77
Q

General functions of Alveolar Type II cells (Type II Pneumocytes)

A
  • Stem cell for Type I and II Pneumocytes
  • Produce pulmonary surfactant
  • Produce lysozyme
78
Q

Type of alveoli cell. Develops from monocytes. Functions in cleaning septal walls via phagocytosis

A

Alveolar macrophage (dust cell)

79
Q

Region between 2 alveoli

A

Interalveolar septum

80
Q

Components of this region of the alveoli include: alveolar type I and type II cells, continuous capillaries, fibroblasts(among numerous other cells), basal lamina, and small amounts of connective tissue with many elastic fibers

A

Interalveolar septum

81
Q

Region where oxygen and carbon dioxide pass between the air and the blood

A

Blood-Gas Barrier

82
Q

Parts of the Blood-Gas Barrier going from air to blood

A
  • Pulmonary surfactant
  • Alveolar type I cells
  • Fused basal lamina (shared between 2 cells)
  • Endothelial cells of the capillary
83
Q

The fused basal lamina of the Blood-Gas Barrier is shared between ____________ cells and _____________ cells

A
  • Alveolar Type I cells

- Endothelial cells (of the capillary)

84
Q

Thoracic _________ provide fibers which will relax bronchial smooth muscle (bronchodilation)

A

Sympathetic chain ganglia

85
Q

Minimum diffusion distance that allow for the most efficient gas exchange

A

Blood-Gas Barrier

86
Q

__________ fibers will cause the paradoxical response of constricting pulmonary blood vessels by stimulating the smooth muscles in the tunica ______

A

Sympathetic

Tunica media

87
Q

Nerve that provides parasympathetic fibers which will constrict bronchial smooth muscle resulting in bronchoconstriction

A

Vagus nerve (C.N. X)

88
Q

Alveolar cell type that appears to synapse with nerve fibers.

A

Alveolar Type II cells

89
Q

Chronic exposure to irritants and metaplasia in the upper respiratory tract will have what effect on goblet cells, ciliated columnar cells, and seromucus glands

A
  • Goblet cells = #’s increase (increased mucus)
  • Ciliated columnar cells = #’s decrease (increased congestion)
  • Seromucus glands = increase in size (more fluid excreted)
90
Q

If much coughing is present from chronic to irritants and metaplasia in the upper respiratory tract, then a person may develop patches of ____________ instead of respiratory epithelium (precancerous condition)

A

Squamous epithelium

91
Q

RDS

A

Respiratory Distress of the Newborn (Hyaline Membrane Disease)

92
Q

Cause of RDS

A

Too few mature Alveolar Type II cells

93
Q

T/F Alveolar Type II cells are the last to mature in the fetus

A

True

94
Q

Treatments for RDS

A

1) Artifical surfactant and CPAP- only a few treatments usually needed
2) Glucocorticoids- given before birth; induces surfactant production

95
Q

Condition where patients have a decrease in elastin and therefore a decrease in alveolar elasticity. Causes an irreversible reduced surface for gas exchange

A

Emphysema

96
Q

Common causes of emphysema

A

1) Inflammation from infection, irritants, smoking, etc.

2) Genetic condition

97
Q

Protein produced by hepatocytes that protects elastin fibers from the enzyme elastase. Protein is inactivated from free radicals coming from cigarette smoke.

A

Alpha 1-Antitrypsin (Alpha 1-AT)

98
Q

Inflammation in the alveoli will attract ______ and _______, both of which release elastase.

A

Macrophages

Neutrophils

99
Q

In the genetic condition that causes emphysema, what is cellular process is malfunctioning and therefore causing emphysema?

A

Hepatocytes in the liver are producing the Alpha 1-AT, but cannot release it due to a genetic condition, therefore the Alpha 1-AT levels are too low

100
Q

T/F People who are Heterozygous for the faulty gene that causes genetic emphysema are affected greatly by it.

A

FALSE.
Gene is inherited dominantly, therefore heterozygous people are affected somewhat while homozygous people are affected greatly