Exam II Concepts

Question 1

what factors do we lump together into one rate constant?

Answer 1

drug dissolution
GI motility
blood flow
drug transport

Question 2

you would use first-order elimination for _____ release drugs

Answer 2

immediate

Question 3

you would use zero-order elimination for ______ release drugs

Answer 3

controlled

Question 4

T/F bioavailability is always between 0-1

Answer 4

True

Question 5

T/F concentration is directly proportional to bioavailability

Answer 5

true

Question 6

many drugs given by IV bolus decline in a two-phase manner; a rapid initial _____ in concentration, followed by a slower ______ as drug that moved into tissue equilibrates with the plasma

Answer 6

decline, decline

Question 7

what does MTT stand for

Answer 7

mean transit time

Question 8

what does MRT stand for?

Answer 8

mean residence time

Question 9

what does MAT stand for?

Answer 9

mean adsorption time

Question 10

why can you still calculate the AUMC if you don’t have a concentration measurement at t=0?

Answer 10

because AUMC at 0 will always equal 0