Concepts in Bio-pharmaceutics Flashcards
define bio-pharmaceutics
study of the relationship between physical, chemical, and biologic sciences as they apply to drugs, dosage forms, and drug action
T/F in passive diffusion solutes flow at a rate predicted from their size or hydrophilicity
true
T/F passive diffusion does not follow Fick’s law
false, it does
what is Fick’s law of diffusion?
the molar flux due to diffusion is proportional to the concentration gradient
what does “J” mean?
flux, movement of mass/area/time
what does “K” mean?
partition coefficient
what does “D” mean?
diffusion coefficient (area/time)
what does “h” mean?
thickness of barrier
what does “Co-Ci” mean?
concentration gradient
does facilitated diffusion require energy?
does it follow Fick’s law?
no, only at low concentrations
does the rate of penetration follow Fick’s law in active transport?
no
which physiochemical properties influence bioavailability of oral drugs? (select all that apply)
a. Oxygenation
b. Particles size
c. Crystalline or amorphous form
d. Hydration
e. Mass of macro or microcrystals
f. pH and pKa
g. Half-life
h. Volume of distribution
i. Salt form
j. Lipid or water solubility
b,c,d,f,i,j
T/F drug metabolism effects oral drug bioavailability
true
what does “Vd” represent?
the apparent volume into which a drug distributes in the body at equilibrium
If Vd ~18L drug distribution is?
probably limited to extracellular fluid.
