Exam II Flashcards
Class III anti-arrhythmetic drugs
K+ channel blockers
Delay repolerization therefore increased AP ie cell less excitable
Solatol
Amiodorone
Class 1A antiarrythmetic
Block fast Na+ channels
Prolongs AP making cell less excitable
Quinidine
Procainamide
Class 1B anti arrythmetics
Black fast Ana channels
Shorten AP
Lidocaine
Mexiletine
Class 1C anti-arrhythmetics
Block fast NA channels
No change AP
Flecainide
Propafenone
Class II anti-arrhythmetics
B blockers
Dec HR and contractility
Atenolol
Propranolol
Esmolol
Solatol
Class IV antiarrhytmetic
Ca+ channel blockers
Dec HR and contractility
Verapamil
diltiazem
amlodipine
Selective B1 blockers (class II anti arithmetics)
Atenolol
Esmolol
Class II antiarryhtmetic (nonselective B blocker) that crosses BBB
Propranolol
Arteriodialators
Reduce afterload
Hydrazaline (inc cGMP)
Verapamil (block ca channels)
Diltiazem (WEAK - block ca channels)
Amlodipine (block ca channels)
Venodialators
Reduce preload
Nitroglycerin Nitrorusside sodium (also arteriodialator)
Both inc NO
Mixed vasodialators
Decrease afterload and preload
Nitroprusside sodium (inc NO)
Sildenafil (inhibit PDE5)
Enalapril
Benazpril
Both via ACE inhibition (prevent angiotensin II fxn)
Positive ionotropes
Digoxin (cardiac glycoside) Dopamine (catecholamine) Dobutamine (synthetic catecholamine) Amrinone and milronone (PGE3 inhibitor) Pimobendan (ca+ sensitized)
Digoxin
Cardiac glycoside
(inhibit Na/K ATPase)
WEAK + inotrope
Vagal influence to decrease HR and firing rate (ie - chronotrope and dromatrope)
MOi: increase inracellular Ca2+
Tx: atrial fibrillation pump failure or DCM
-:arrhythmia vomit GI azotemia
(Hypokalemia make toxicity worse)
Pimobendan
+ ionotrope = inc CO
Increased affinity of traps in C to Ca sensitizing apparatus to enhance contractility
Weak ionotrope that has vagal influence that decreases HR
Ie weak positive ionotrope because concurrent negative chronotrope
Digoxin