Exam II Flashcards

1
Q

Class III anti-arrhythmetic drugs

A

K+ channel blockers
Delay repolerization therefore increased AP ie cell less excitable

Solatol

Amiodorone

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2
Q

Class 1A antiarrythmetic

A

Block fast Na+ channels
Prolongs AP making cell less excitable

Quinidine
Procainamide

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3
Q

Class 1B anti arrythmetics

A

Black fast Ana channels
Shorten AP

Lidocaine
Mexiletine

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4
Q

Class 1C anti-arrhythmetics

A

Block fast NA channels
No change AP

Flecainide
Propafenone

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5
Q

Class II anti-arrhythmetics

A

B blockers
Dec HR and contractility

Atenolol
Propranolol
Esmolol
Solatol

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6
Q

Class IV antiarrhytmetic

A

Ca+ channel blockers
Dec HR and contractility

Verapamil
diltiazem
amlodipine

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7
Q

Selective B1 blockers (class II anti arithmetics)

A

Atenolol

Esmolol

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8
Q

Class II antiarryhtmetic (nonselective B blocker) that crosses BBB

A

Propranolol

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9
Q

Arteriodialators

A

Reduce afterload

Hydrazaline (inc cGMP)

Verapamil (block ca channels)
Diltiazem (WEAK - block ca channels)
Amlodipine (block ca channels)

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10
Q

Venodialators

A

Reduce preload

Nitroglycerin 
Nitrorusside sodium (also arteriodialator)

Both inc NO

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11
Q

Mixed vasodialators

A

Decrease afterload and preload

Nitroprusside sodium (inc NO)

Sildenafil (inhibit PDE5)

Enalapril
Benazpril
Both via ACE inhibition (prevent angiotensin II fxn)

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12
Q

Positive ionotropes

A
Digoxin (cardiac glycoside)
Dopamine (catecholamine)
Dobutamine (synthetic catecholamine) 
Amrinone and milronone (PGE3 inhibitor) 
Pimobendan (ca+ sensitized)
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13
Q

Digoxin

A

Cardiac glycoside
(inhibit Na/K ATPase)
WEAK + inotrope

Vagal influence to decrease HR and firing rate (ie - chronotrope and dromatrope)

MOi: increase inracellular Ca2+

Tx: atrial fibrillation pump failure or DCM

-:arrhythmia vomit GI azotemia
(Hypokalemia make toxicity worse)

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14
Q

Pimobendan

A

+ ionotrope = inc CO

Increased affinity of traps in C to Ca sensitizing apparatus to enhance contractility

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15
Q

Weak ionotrope that has vagal influence that decreases HR

Ie weak positive ionotrope because concurrent negative chronotrope

A

Digoxin

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16
Q

This positive ionotrope increases the sensitivity of ca2+ causing increased contractility

A

Pimobendan

17
Q

Only class II antiarythmetic that crosses BBB with 1/2 life <2hrs

A

Propranolol

18
Q

Non selective beta blockers used as CII antiarthmetics

A

Propranolol and solatol

19
Q

B1 selective beta blockers used as CII antiarthmetics

A

Atenolol

Esmolol

20
Q

Weak arteriodialator

Via blocked Ca channels

A

Diltiazem

21
Q

Arteriodialators via blocked Ca channels

A

Verapamil
Amlodipine
Diltriazam (weak)

22
Q

Mixed vasodialators via ACE inhibition

A

Enalapril

Benazepril

23
Q

Mixed vasodialators cia PDE5 inhibition

A

Sildenafil

24
Q

Which anti fungal should not be given to cats with FIV FelV

A

Griseofluvin

25
Q

Which antifungal can be used for pulse therapy

A

Itraconazole

26
Q

Which anifungal mostly used in large animals

A

Iodides

27
Q

Which antifungal selective for dermatophytes

A

Griseofluvin

28
Q

Which antifungal is the first choice for small animal sporotrichosis …. large animal?

A

Intraconazole

Iodides

29
Q

What is amphotericin B not effective against

A

Aspirgillus

30
Q

What is ketoconoazole not effective against

A

Spirotrichosis esp cats

31
Q

Which antifungal has the best CNS and ocular distribution

A

Fluconazole

32
Q

What does the fungicidal antifungal terbinafine target

A

Squalene epoxidase

Superficial mycosis

33
Q

What is the safest azole that is well tolerated in cats

A

Fluconazole

34
Q

Which injectable anesthetic has a high percentage of propylene glycol that can cause hemolysis as well as swapping and gagging during induction but is chosen for relatively stable CV effects

A

Etomadate