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Pathology 1 > Exam II > Flashcards

Exam II Flashcards

1
Q

d/dt M➰ alt M2

A

Il-13,14

➡️il-10, TGF-ß

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2
Q

Acute inflam
Thin clear fl in conjunctiva + nasal mucosa
Hyper secr of inflam gl.

A

Serous inflam

Transudate

Ex: poison ivy

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3
Q

Acute inflam
Thick fl mucoid in RT, GIT, Repro tract
⬆️goblet cell secr

A

Catarrhal/mucoid inflam

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4
Q

Fibronous inflam

A

Thick stringy

⬆️perm bv➡️ leak fibrinogen

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5
Q

Collagen syn

A

TGF-ß + PDGF

❇️fibroblast & myofib

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6
Q

M➰/mast/Tcell➡️

❇️⬆️adhesion mol exp
Cytokine secr
Systemic effects
Fever🔥

A

TNF & il-1

Pro-inflam

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7
Q

Anti-inflam made by M➰

➡️❇️apoptosis

A

il-10
TGF-ß
Lipoxin

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8
Q

M➰➡️❇️APP

A

il-6

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9
Q

M➰/endo/Tcell/mast➡️ recruit WBC + chemotaxis

Ex: recruit PMN

A

Chemokines

il-8

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10
Q

Chronic inflm

DC/M➰:⬆️IFN-➰ prod

A

il-12

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11
Q

Chronic inflm

Tcell/NK cell➡️❇️M➰ kill fn

A

IFN-➰

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12
Q

Chronic inflm

Th17➡️recruit PMN + monocytes

A

il-17

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13
Q

Vasoactive peptides➡️❇️degran Mast/baso/eos: rel histamine + inflam mediators

A

Bradykinin + Substance P

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14
Q

1• link bw coag + inflm sys
Moblize P-selectin
❇️chemokine prod
PAF+ NO

A

Thrombin

➡️syn fibrin

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15
Q

❇️kininform/thrombin/fibrinolytic sys & C’

A

Factor 12a

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16
Q

Th1 ➡️ cellular imm response

Foreign body, endogen Ag, intracell, fungi

A

il-12 + IFN-➰

✳️focal NODULAR Granulomas

Tuberculoid

17
Q

Th2➡️humoral resp

Expgen Ag, allergy

A

il-10 + il-4

✳️DIFFUSE granulomas

18
Q

Granulomatus inflam

A

1• M➰, Langhans GC
Few WBC + plasma cells

Core: M➰➡️necrosis
Border: WBC➡️fibrosis

19
Q

TGF-ß

PDGF

A

Plat/T/M➰/endo/keratino/fib

✳Collagen syn
⛔️epi growth
❇️fibroblast prolif + taxis

20
Q

TNF

A

M➰/mast/T

❇️M➰➡️cytokine storm + APP

21
Q

Bed sore

A

Decubitus ulcer

Due to improper wound healing

22
Q

Complications

A
  1. Dehiscence
  2. Proud flesh=exub gran
  3. Scirrhous rxn
23
Q

Fibrin polymerize on necrotic epi

A

Fibronecrotic inflam

Exudate
Diptheritic mem: GIT, trachea
Hyaline mem: lungs

24
Q

Purulent exudate fl ⏫PMN

A

Supprative

Fibrinosupprative (w/FIBRIN)=CHEESY

Pus
Caeous
Abcess: focal
Empyema: pus in body cavity
Cellulitis/phlegmon: fascia plane/SQ

Pathology 1 (3 decks)

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