Exam I

Question 1

Occlude Q of VR➡️local ischemic necrosis

Answer 1

Infarct

Question 2

Unresponsive to normal growth H➡️

Mass of cells

Answer 2

Neoplasm/tumor

Question 3

Pathologic

Death of tissue in LIVING animal

Answer 3

Necrosis

Question 4

Gross lesion description

Answer 4

Size
Shape/colour
Texture
Distribution: focal, multifoc, diss, locally extensive, diffuse
Sp gross ft

Question 5

-opathy

Answer 5

Abnormal state of _____

Question 6

-osis

Answer 6

Degen of
Non-inflam non-neoplastic dis of
Necrosis of

Question 7

Morpho Dx

Answer 7

Dominant lesion

Extent
Duration
Distribution
Organ+lesion type

Question 8

State of ⬇️Q

Answer 8

Ischemia

Question 9

Coag necrosis

Answer 9

Outline of tissue cells, hypoxic cell death
Infarct➡️necrosis

Sk.M, ❤️, kidney

Question 10

Liq necrosis

Answer 10

Influx of Neutrophils➡️bacteria
Pus/abscess

CNS : malacia
Pyometra

Question 11

Reversible acute cell injury➡️

3 cell responses

Answer 11

DEGENERATION
Hydropic degen: cell swell/ballooning, cytotoxic edema, ☁️ swelling

Lipidosis: greasy liver, ❤️M, skM, kidney➡️Steatosis/fatty change

Glycogen accum: ab metabolism, pale large liver

Question 12

Hyperplasia

Answer 12

⬆️#cells

Physio: GH compensatory
Patho: ⏫GH, wart, nodule spleen, liver, pancreas

Question 13

Hypertrophy

Answer 13

⬆️size

Question 14

Extracell accum: imm complex deposits in wall of bv➡️WBC destroy wall➡️ low Q➡️clot & hemorr

Answer 14

Fibrinoid necrosis

Question 15

Patho glycoprotein secr & polymerize

Answer 15

AMYLOID: RIA IF

Reactive Sys amyloidosis
Ig-derived 
Amyloid-ß
Islets amyloid polypeptide
Familial amyloidosis

Question 16

Coag cascade

Answer 16

Int: hageman F12, 11, 9, 8

Ext: F3, 7

Com: stewart prower F10, 5,13, thrombin F2, fibrinogen F1

Question 17

Vit K dep CF

Answer 17

CF 2,7,9,10
Protein C+S➡️⛔️CF 8a+5a

Vita K def➡️ BIG bleeds
Warfarin: ⬆️PT/PTT/ACT

Question 18

Fibrinolysis

Answer 18

CF 12a➡️plasmin
t-PA:❇️plasminogen
Plasma +tissue➡️ u-Pa

All lyse clot/fibrinogen

Question 19

vWF disease

Answer 19

Platelet ct: normal + ⬆️bucal bleed t
PT/PTT/ACT: normal

⬇️vWF

Question 20

Hemophilia

Answer 20

⛔️ pro-coag protein in blood plasma

Hemo A: CF8
Hemo B: CF9

⬆️PTT/ACT t = int path

Question 21

Thrombus fates

Answer 21

Dissolve (ideal)
Incorp bv wall➡️narrows
Recanalization
Embolus➡️ detach frag

Question 22

Disseminated intravasc coag (DIC)

Answer 22

ALWAYS 2• + patho
⏫ clots➡️depletes CF: ✳️hemorr

Thrombo-hemorrhagic disorder

➡suffisive hemorr on ❤️ + lungs

Question 23

Final common path for several lethal events: ⬇️ tissue perfusion+ cell hypoxia

Answer 23

Shock

Cardiogenic
Hypovolemic
Blood maldistr: septic, neurogenic (ANS), anaphylatic