Exam #4 Vocab Flashcards
resistance mutation
random gene change produces a gene causing resistance
natural selection
when the antibiotic is present (environment) bacteria with the resistance gene (genetic differences) survive and reproduce (difference in reproduction)
trade-off
when the antibiotic is absent (environment) bacteria with the resistance gene (genetic differences) reproduce more slowly than the susceptible bacteria (differences in reproduction)
penicillin
kills gram-positive bacteria by damaging peptidoglycan in the gram-positive and cell wall
penicillin-resistant bacteria
produce a protein that cuts penicillin molecules in half before they damage the cell wall
KPC gene
gives resistance to multiple antibiotics
virulence
the degree of damage caused by a pathogen to its host
physiology
study of internal organismic functioning, especially the physical and chemical aspects of function
homeostasis
maintenance of stable internal conditions
set “point”
the usually maintained homeostatic conditions
negative feedback
a “sensor” triggers a response by a physiological system that returns the conditions to the set point
positive feedback
a “sensor” triggers a response by a increase the deviation from the set point (amplifies until end point)
hematocrit
erythrocyte blood volume (percentage of blood)
anemia
low hematocrit
hypoglycemia
low blood sugar; brief hypoglycemia is normal after not eating for a while
hyperglycemia
high blood sugar; brief hyperglycemia is normal after carbohydrate consumption
clinical hypoglycemia
pancreas cells “over-react” to high glucose, secrete too much insulin then the liver stores too much glucose causing hypoglycemia
type 1 diabetes
insulin-producing pancreas cells are killed (usually during childhood), thus no insulin; cannot “direct” liver to store glucose or direct other cells to absorb and use glucose (hyperglycemic but cells starve)
type 2 diabetes
liver cells have a reduced sensitivity to insulin; the liver does not respond well to insulin; this leaves blood glucose high (genetic predisposition, age, smoking, or being overweight make it more likely)
compensation
when the carbonate buffer system and body systems keep blood PH near 7.4
acidosis/ acidemia
blood ph <7.35; affects brain and muscles (twitching and confusion, eventually results in coma and death)
respiratory acidosis/ acidemia
too much CO2 in blood (usually due to lung malfunction-can’t release CO2)
metabolic acidosis/ acidemia
add or retain H+ (poisoning- add H+, diabetic acidosis- add H+, or kidney malfunction- can’t release H+)