Exam 4 Nervous System Flashcards
Synapse
Site of communication between two or more neurons or between a neuron and another cell
Types of Synapses
Electrical and Chemical
Electrical Synapse
Structure - Gap junction formed between pre and post synaptic membranes. Protein pores permit ions to pass between cells.
Function - Membrane potential passes from cell to cell
Examples - Intercalated discs in cardiac muscle or gap junctions in smooth muscle
Presynaptic Membrane
The neuron that passes the impulse to another neuron
Postsynaptic Membrane
The neuron receiving the signal or impulse
Excitatory Neurotransmitter
Cause depolarization and promote the generation of action potentials
Inhibitory Neurotransmitter
Causes hyperpolarization and suppress the generation of action potentials
Chemical Synapse
All synapses and communications between neurons involve neurotransmitters
Chemical Conduction at the Synapse
There is a space (synaptic cleft) between the axon terminal and the adjacent neuron. As the action potential reaches the end of the axon, a chemical is released that travels across the synaptic cleft to the next neuron to alter its electric potential
Acetylcholine
Primarily direct, through binding to chemically gated channels
In the PNS - Plays a role in skeletal muscle movement, as well as in the regulation of smooth muscle and cardiac muscle
In the CNS - Involved in learning, memory, and mood
Norepinephrine
Widely distributed in the brain and in portions of the ANS
Typically has an excitatory, depolarizing effect on the postsynaptic membrane, but the mechanism is quite distinct from that of ACh
Dopamine
Has both inhibitory and excitatory areas of the brain
Inhibitory effects has an important role in our precise control of movements
Excitatory effects - Cocaine inhibits the removal of dopamine from synapses in specific areas of the brain. The resulting rise in dopamine concentrations at these synapses is responsible for the “high” experienced by cocaine users
Serotonin
Inadequate serotonin production can have effects on a person’s attention and emotional states and may be responsible for many cases of severe chronic depression.
Antidepressant drugs inhibit the reabsorption of serotonin by axon terminals. This inhibition leads to increased serotonin concentrations at synapses, and over time, the increase may relieve the symptoms of depression.
GABA
Gamma-aminobutryic acid
Has an inhibitory effect; GABA release in the CNS appears to reduce anxiety and some antianxiety drugs work by enhancing this effect.
Neuromodulators
A compound released by a neuron that affects the sensitivity of another neuron to a neurotransmitter
Examples: Opoids such as endorphins
Actions of a Neuromodulator
Alters rate of release of neuromodulators
Bind receptor on neuron and activate enzymes
EPSP
Excitatory Postsynaptic Potential
Graded depolarization caused by the arrival of a neurotransmitter at the postsynaptic membrane
IPSP
Inhibitory Postsynaptic Potential
Graded hyperpolarization of the postsynaptic membrane. the neuron is said to be inhibited because a larger than usual depolarizing stimulus is needed to bring the membrane potential to threshold.
Postsynaptic Potentials
Graded potentials that develop in the postsynaptic membrane in response to a neurotransmitter
Temporal Summation
The addition of stimuli occurring in rapid succession t a single synapse that is active repeatedly.
This form of summation can be likened to using a bucket to fill up a bathtub: You can’t fill the tub with a single bucket of water but you will fill it eventually if you keep repeating the process.
Spatial Summation
Occurs when simultaneous stimuli applied at different locations have a cumulative effect on the membrane potential.
You could fill a bathtub immediately if 50 friends emptied their bucket into it all at the same time.
Presynaptic Inhibition
Inhibition that reduces the amount of neurotransmitter released when the action potential arrives there, and thus reduces the effects of synaptic activity on the postsynaptic membrane.
Presynaptic Facilitation
Activity at an axoaxonic synapse increases the amount of neurotransmitter released when an action potential arrives at the axon terminal.
Principles of Synaptic Transmission
- Unidirectional
- Susceptible to fatigue
- Susceptible to drugs and medications
- Oxygen consumption
- Summation occurs
Neuronal Pools
Functional groups of neurons that integrate incoming information from receptors which then forward processed information to other designations
Diverging Circuit
Spread of information from one neuron to several neurons, or from one pool to multiple pools
Converging Circuit
A mechanism for providing input to a single neuron from multiple sources
Serial Processing
Information is relayed in a stepwise fashion, from one neuron to another or from one neuronal pool to the next
Parallel Processing
Occurs when several neurons or neuronal pools process the same information simultaneously
Divergence must take place before parallel processing can occur
Reverberation
Collateral branches of axons somewhere along the circuit extend back toward the source of an impulse and further stimulate the presynaptic neurons.
Length of Spinal Cord
Approximately 45 cm (18 in) long, with a maximum width of roughly 14 mm.
Segments of the Spinal Cord
- Cervical enlargement
- Lumbar enlargement
Cervical Enlargement
Supplies nerves to the shoulder and upper limbs
Lumbar Enlargement
Provides innervation to structures of the pelvis and lower limbs
Conus medularis
Inferior to the lumbar enlargement the spinal cord becomes tapered and conical.
Dorsal Root Ganglia
Located near the spinal cord, every spinal cord segment is associated with a pair of these; these ganglia contain the cell bodies of sensory neurons
Dorsal Root
Axons of the neurons form the dorsal root, which bring sensory information into the spinal cord
Ventral Roots
A pair of ventral roots contains the axons of motor neurons that extend into the periphery to control somatic and visceral effectors.
Spinal Nerve
Distal to each dorsal root ganglion
The sensory and motor root are bound together into a single spinal nerve
Contain both afferent and efferent fibers
31 pairs of spinal nerves
Gray Matter
Integrates information and initiates commands
Dominated by the cell bodies of neurons, neuroglia, and unmyelinated axons
White Matter
Carries information from place to place
Contains large numbers of myelinated and unmyelinated axons
Gray Commisures
Posterior to and anterior to the central canal contain axons that cross from one side of the cord to the other before they reach an area in the gray matter
Anterior Gray Horns
Contain somatic motor nuclei
Posterior Gray Horns
Contain somatic and visceral sensory nuclei
Lateral Gray Horns
Located only in the throacic and lumber segments and contain visceral motor nuclei
Anterior White Columns
Lie between the anterior gray horns and the anterior median fissure
Interconnected by the anterior white commissure
Anterior White Commissure
A region where axons can cross from one side of the spinal cord to the other
Lateral White Columns
The white matter between the anterior and posterior columns on each side makes up the lateral white column
Posterior White Columns
Lie between the posterior gray horns and the posterior median sulcus
Spinal Meninges
A series of specialized membranes surrounding the spinal cord, provide the necessary physical stability and shock absorption
Dura Mater
Layer that forms the outermot covering of the spinal cord
Contains dense collagent fibers that are oriented along the longitudinal axis of the cord
Arachnoid Mater
The middle meningeal layer
The inner surface of the dura mater and the outer surface of the arachnoid mater are covered by simple squamous epithelia
Pia Mater
The innermost meningeal layer
Consists of a meshwork of elastic and collagen fibers that is firmly bound to the underlying neural tissue
Epineurium
Outermost layer of the nerve
Perineurium
Middle layer of the nerve
Separate adjacent bundles of nerve fibers in a peripheral nerve
Endoneurium
Inner layer of the nerve
Surround individual nerve fibers
Plexuses
Interlacing of nerves from which other nerves arise; all white matter
Cervical Plexus
C1-C5; Innervates the muscles of the neck and extend into the thoracic cavity
Brachial Plexus
C5-T1; Innervates the pectoral girdle and upper limb
Lumbar Plexus
L1-L4; Primarily deals with movement of the hip or upper leg
Sacral Plexus
L4-S4
Reflex Arc
Impulse arrives at the cell and activates the receptor. The receptor activates the sensory neuron which carries information to the CNS. The integrator integrates information for the motor neuron to carry. The motor neuron tells the neurotransmitters to release. The peripheral effector responds to this release which, for example, would pull your hand away from the tack.
Innate Reflex
Results from the connections that form between neurons during development
Genetically determined
Acquired Reflex
Learned motor patterns; developed
Somatic Reflex
Control skeletal muscle contractions
Include superficial and stretch reflexes
Visceral Reflex
Control actions of smooth and cardiac muscles, glands, and adipose tissue
Monosynaptic Reflex
One synapse; involve the simplest reflex arc
Polysynaptic Reflex
Multiple synapses; longer delay between stimulus and response which has to do with the amount of synapses involved
Example of Stretch Reflex
Automatically regulates skeletal muscle length
“Knee-jerk” or patellar reflex - when a physician taps your patellar tendon with a reflex hammer, receptors in the quadriceps muscle are stretched. The distortion of the receptors in turn stimulates sensory neurons that extend into the spinal cord, where they synapse on motor neurons that control the motor units in the stretched muscle. This leads to a reflexive contraction of the stretched muscle that extends the knee in a brief kick.
Tendon Reflex
Monitors the external tension produced during a muscular contraction and prevents tearing or breaking of the tendons.
Withdrawal Reflex
Move affected parts of the body away from a stimulus. Painful stimuli trigger the strongest withdrawal reflexes, but these reflexes are sometimes initiated by the stimulation of touch receptors or pressure receptors.
Crossed Extensor Reflex
Involves a contralateral reflex arc because the motor response occurs on the side opposite the stimulus
Reinforcement
An enhancement of spinal reflexes by stimulating excitatory neurons in brain stem or spinal cord creating EPSPs at reflex motor neurons facilitating postsynaptic neurons
Spinal Shock
Loss of all neurological activity below the level of injury
Decerebrate Rigidity
Caused by extensive damage to the brainstem; There is head extension with body arched, the arms are extended, adducted, and pronated; the legs are extended with plantar flexion of the feet
Ventricular System of the Brain
Set of communicating cavities within the brain; these structures are responsible for the production, transport and removal of cerebrospinal fluid.
Lateral Ventricles
Located within their respective hemisphere of the cerebrum; they have horns which project into the frontal, occipital, and temporal lobes. The volume of the lateral ventricles increases with age.
Third Ventricle
The lateral ventricles are connected to the third ventricle by the foramen of Monro.
Situated in between the right and left thalamus. The anterior surface of the ventricle contains two protrusions - supraoptic recess and infundibuar recess)
Fourth Ventricle
Receives CSF from the third ventricle via the cerebral aqueduct; it lies within the brainstem, at the junction between the pons and medulla oblongata.
Function of Cerebrospinal Fluid
Protection - acts as a cushion of the brain
Buoyancy - net weight of brain is reduced to 25 grams and it prevents excessive pressure on the base of the brain
Transports nutrients, chemical messengers, and waste products.
Formation of Cerebrospinal Fluid
Choroid plexus - an area within each ventricle that produces CSF
Produced from arterial blood by the choroid plexuses of the lateral and fourth ventricles by a combined process of diffusion, pinocytosis, and active transfer. A small amount is also produced by ependymal cells.
Circulation of Cerebrospinal Fluid
Choroid plexus secretes the CSF into the lateral ventricle, then it travels to the third ventricle by the intraventricle foramen. From there it moves to the 4th ventricle through the cerebral aqueduct.
Medulla Oblongata Location
Lowest part of the brainstem
Medulla Oblongata Functions
Carries out and regulates life sustaining functions such as breathing, swallowing, and heart rate.
Reticular Formation
Loosely organized mass of gray matter that contains embedded nuclei. It extends from the medulla oblongata to the midbrain.
Reflex Centers
Receive inputs from cranial nerves, the cerebral cortex, and the brain stem.
2 Major Groups - cardiovascular centers and respiratory rhythmicity centers
Cardiovascular Centers
Adjust heart rate, the strength of cardiac contraction, and the flow of blood through peripheral tissues