Exam 4 getting old

Question 1

Mediator of aging and related diseases

Answer 1

mTOR

Question 2

As age, decrease beta 1 responsiveness (sympathetic) results in what?

Answer 2

a) reduced maximum heart rate

b) reduction contractility, resulting in a decrease in maximum CO with stress.

Question 3

Tau and amyloid beta protein is a sign of?

Answer 3

Alzheimer’s disease

Question 4

How long have to do rape kit

Answer 4

120 hours, also give HIV prophylaxis

Question 5

Average age menopause

Answer 5

51, 12 months amenorrhea

Question 6

Menopause symptoms

Answer 6

Hot flashes, insomnia, weight gain, cognitive changes, diminished libido, musculatoskeletal, painful sex

Question 7

Hot flash occurs because why?

Answer 7

Control center narrows,

Question 8

Post menopause what happen FSH and progesterone and estradiol?

Answer 8

FSH Increase, progesterone and estradiol decrease

Question 9

Late transition define

Answer 9

> 60 days amenorrhea

Question 10

Alternative to estrogen for menopause treatment

Answer 10

Gabapentin/Pregabalin, Venlafaxine/Desvenlafaxine, Paroxetine, Citalopram/Escitalopram

Question 11

When get menopause symptoms

Answer 11

Couple years before menopause and couple years after

Question 12

Who give hormone replacement to (age)?

Answer 12

50-59 year old women with menopause symptoms, slight increase risk breast cancer, estrogen and progesterone if she has a uterus

Question 13

Transdermal vs oral estradiol CVA and VTE risk

Answer 13

Transdermal decreased risk compared to oral

Question 14

Estrogen helps with

Answer 14

Hot flashes and vaginal atrophy, osteoporosis, dementia, and heart disease

Question 15

What give someone with hot flashes that cannot have estrogen?

Answer 15

Paroxetine low dose

Question 16

Premature ejaculation treatment?

Answer 16

Low dose SSRIs

Question 17

Early menopause is defined by

Answer 17

2-6 years after menopause (LMP)

Question 18

Postmenopausal RX for Vulvovaginal Pain and Low Libido

Answer 18

Vaginal estrogen

Question 19

Criteria for frailty

Answer 19

• unexplained weight loss;
▪ fatigue;
▪ weakness (measured as grip strength);
• slow walking speed,
▪ low levels of physical activity.

Question 20

Delirium signs

Answer 20

Acute decline cognitive function and impaired consciousness

Question 21

What particula drugs should be avoided to decrease fall risk

Answer 21

Benzodiazepines and z drugs/hypnotics and anticholinergic (TCAs, antihistamine,antispasmodic, anti Parkinson’s)

Question 22

First pass drugs

Answer 22

Oral drugs, must go through liver first before systemic effects