Exam 4 getting old Flashcards
Mediator of aging and related diseases
mTOR
As age, decrease beta 1 responsiveness (sympathetic) results in what?
a) reduced maximum heart rate
b) reduction contractility, resulting in a decrease in maximum CO with stress.
Tau and amyloid beta protein is a sign of?
Alzheimer’s disease
How long have to do rape kit
120 hours, also give HIV prophylaxis
Average age menopause
51, 12 months amenorrhea
Menopause symptoms
Hot flashes, insomnia, weight gain, cognitive changes, diminished libido, musculatoskeletal, painful sex
Hot flash occurs because why?
Control center narrows,
Post menopause what happen FSH and progesterone and estradiol?
FSH Increase, progesterone and estradiol decrease
Late transition define
> 60 days amenorrhea
Alternative to estrogen for menopause treatment
Gabapentin/Pregabalin, Venlafaxine/Desvenlafaxine, Paroxetine, Citalopram/Escitalopram
When get menopause symptoms
Couple years before menopause and couple years after
Who give hormone replacement to (age)?
50-59 year old women with menopause symptoms, slight increase risk breast cancer, estrogen and progesterone if she has a uterus
Transdermal vs oral estradiol CVA and VTE risk
Transdermal decreased risk compared to oral
Estrogen helps with
Hot flashes and vaginal atrophy, osteoporosis, dementia, and heart disease
What give someone with hot flashes that cannot have estrogen?
Paroxetine low dose
Premature ejaculation treatment?
Low dose SSRIs
Early menopause is defined by
2-6 years after menopause (LMP)
Postmenopausal RX for Vulvovaginal Pain and Low Libido
Vaginal estrogen
Criteria for frailty
• unexplained weight loss; ▪ fatigue; ▪ weakness (measured as grip strength); • slow walking speed, ▪ low levels of physical activity.
Delirium signs
Acute decline cognitive function and impaired consciousness
What particula drugs should be avoided to decrease fall risk
Benzodiazepines and z drugs/hypnotics and anticholinergic (TCAs, antihistamine,antispasmodic, anti Parkinson’s)
First pass drugs
Oral drugs, must go through liver first before systemic effects
