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Infectious Diseases > Exam 4 - Clinical treatment of antivirals > Flashcards

Exam 4 - Clinical treatment of antivirals Flashcards

1
Q

HSV 1 location

A

oral mucosa

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2
Q

HSV 2

A

genital mucosa

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3
Q

HSV 1+2

A

CNS

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4
Q

when should acyclovir be dose adjusted

A

renal and obesity

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5
Q

when should acyclovir be started in recurrent genital HSV

A

start with promodal or onset of symptoms

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6
Q

acyclovir
HSV encephalitis treatment

A

10mg/kg IV x14-21 days

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7
Q

valacyclovir
genital HSV
primary treatment

A

1g bid x7-10 days

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8
Q

valacyclovir
genital hsv
suppression treatment

A

500-1000mg qd in immuno
500mg bid in HIV

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9
Q

what is the major DDI with famiciclovir

A

probenicid
will decrease renal function and increase the serum concentration

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10
Q

what is varicella zoster virus

A

DNA virus that can cause chicken pox and later shingles

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11
Q

what is the preferred drug for shingles

A

valacyclovir

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12
Q

when should famciclovir be used in VZV

A

shingles only
start within 72 hours of onset

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13
Q

who is most likely to get CMV

A

children or those with weakened immune systems

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14
Q

how can resistance to ganciclovir occur

A

UL97 gene mutation leading to viral kinase deficiency

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15
Q

what are three counseling points for ganciclovir

A

take with food
renally dose adjust
avoid other cytotoxic drugs (probenecid)

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16
Q

what is the most important AE of ganciclovir

A

bone marrow suppression

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17
Q

is BM suppression reversible in ganciclovir

A

yes
monitor labs

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18
Q

what CMV treatments is ganciclovir used for

A

CMV retinitis
CMV esophagitis, colitis, pneumonitis, neurologic disease
prevention and treatment of CMV in transplant pts

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19
Q

what dose is used for ganciclovir in CMV patients

A

high dose
5/mg/kg IV q12 x14-21 days

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20
Q

valganciclovir dose adjustment

A

renally dose adjust

21
Q

should valganciclovir be given with food

22
Q

when is valganciclovir used in CMV

A

CMV retinitis induction and maintenance
prevention of CMV in transplant patients

23
Q

what is a monitoring parameter of letermovir

A

kidney function and DDIs

24
Q

when is letermovir used

A

prophylaxis of CMV (rare)

25
Q

what are the DDIs of letermovir

A

pimozide
alkaloids
statins
amiodarone
warfarin
voriconazole
rifampin
sirolimus/tacrolimus

26
Q

when is foscarnet mostly used

A

last line in drug resistant HSV, VZV, CMV

27
Q

what are the DDIs of foscarnet

A

nephrotoxic drugs
pentamidine

28
Q

do you dose adjust foscarnet

A

yes, renally dose adjust

29
Q

what is the main AE of foscarnet

A

nephrotoxicity (dose limiting)

30
Q

what are the drugs for tamiflu

A

zanamivir
oseltamivir
peramivir

31
Q

what is the formulation for zanamivir

A

oral inhalation

32
Q

what is the formulation for oseltamivir

A

oral capsules

33
Q

what is the formulation for peramiriv

A

iv formulation

34
Q

oseltamivir dose adjust

A

in CrCl < 30

35
Q

oseltamivir time to give

A

symptomatic < 2 days
prophylaxis

36
Q

can you give vaccines with oseltamivir

A

inactivated –> any time
live –> > 2 weeks before or 48 hours after admin

37
Q

zanamivir AEs

A

bronchospasms or lung things

38
Q

who can zanamivir be given to

A

> 7 years old

39
Q

peramivir dosing

A

600mg IV infusion one time

40
Q

Xofluza (baloxavir marboxil) should not be taken with what

A

dairy products or Calcium products

41
Q

xofluza age cut off

42
Q

what flu regimen should not be used

A

amantadine + rimantadine

43
Q

what drugs can be used for HSV 1/2

A

acyclovir
valacyclovir
ganciclovir
valganciclovir
famciclovir
foscarnet

44
Q

what are the drugs of choice for HSV1/2

A

acyclovir
valacyclovir

45
Q

what drugs can be used in VZV

A

acyclovir
valacyclovir
ganciclovir
valganciclovir
famciclovir
foscarnet

46
Q

what are the drugs of choice for VZV

A

acyclovir
valacyclovir

47
Q

what drugs can be used in CMV

A

ganciclovir
valganciclovir
letermovir
foscarnet

48
Q

what are the drugs of choice in CMV

A

ganciclovir
valganciclovir

Infectious Diseases (28 decks)

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