exam 4- cardiovascular 1 Flashcards

1
Q

what is the job of the cardiovascular system?

A

to provide nutrients for metabolic activity- provide oxygen, electrolytes, and nutrients to tissues
- transport delivers nutrients & carries away all the produced waste products from the tissues

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2
Q

in the cardiovascular system, transport by bodily fluids is called ___ to and from major systems of the body

A

bulk transport

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3
Q

list the 4 components of the cardiovascular system:

A

1- heart (the pump): propels blood around the body

2- arterial system: distributes blood to body organs and acts as a pressure reservoir

3- capillary system: the site of transfer (exchange) of substances b/w blood & tissue (system of many small blood vessels)

4- venous system: the route of return of blood from body to heart, also serves as a volume reservoir

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4
Q

cardiac muscle is considered ___ ___ muscle

A

modified skeletal

  • striated (has actin & myosin), functions similar to skeletal muscle with some major modifications
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5
Q

the heart is entirely made of ___

A

muscle

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6
Q

describe nerves in the heart

A

nerves leading to heart but no nerves running through the heart

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7
Q

instead of cardiac muscle being arranged linearly like skeletal muscle…

A

it is arranged in spiral, basket-weave arrangement (this makes cardiac muscle most complexly organized muscle in body)

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8
Q

are there afferent pain receptors in the heart?

A

no afferent pain receptors running from the heart –> if heart is diseased or malfunctioning, there is no direct signal letting you know (precursors of heart attack are known as referred pain)

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9
Q

describe the path of blood to the heart

A

blood returns to heart thru 2 major veins: superior vena cava (drains head & thoracic cavity) and inferior vena cava (drains abdomen & lower appendages), they bring deoxygenated blood back to heart, enter heart through right atrium –> tricupsid valve (one-way atrioventricular (AV) valve, separates right atrium from right ventricle- has 3 flaps) –> right ventricle –> pushes blood out thru pulmonary artery –> blood goes directly to lungs where CO2 is given off and oxygen is picked up (blood gets oxygenated in capillaries of lungs) –> oxygenated blood returns to heart thru pulmonary vein (only vein in body that carries oxygenated blood) –> pulmonary vein returns blood to left atrium –> bicupsid/mitral valve (left AV valve) –> left ventricle –> pumps blood out of aorta –> aorta divides into major arteries, sends blood to major metabolic tissues of the body

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10
Q

name the 2 separate circulatory loops in cardiovascular system and their purpose

A

pulmonary circulation (to lung and back)
systemic circulation (to major organs systems and back)

  • these 2 loops prevent the mixing of oxygenated & deoxygenated blood
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11
Q

pulmonary artery is the only artery in the body that carries ___ blood

A

deoxygenated

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12
Q

pulmonary vein is the only vein in the body that carries ___ blood

A

oxygenated

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13
Q

as a consequence of the 2 separate circulatory loops, there’s some downstream effects

A

the heart is a functional syncytium, meaning there are 2 separate components, but it contracts at once as if it were one large muscle cell (b/c individual muscle cells communicate with each other and contract in coordinated manner, then relaxes all at once in unified manner)

  • unified state of contraction of the heart is called systole, state of relaxation called diastole
  • when heart contracts, generates pressure on fluid in the 4 chambers (pressure generated called systolic pressure), when relaxes, the pressure drops (lowest pressure called diastolic pressure)
  • measured systolic/diastolic
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14
Q

describe the different in pressure generated in the 4 diff chambers of the heart

A

1- right & left atrium (thin-walled, only have to pump blood through their AV valves into ventricles) : low pressures, 2-8 (right) and 2-10 (left) range of pressures

2- right ventricle (only pumps blood to lungs and back, pulmonary circulatory loop), right ventricle wall is relatively thin, generates relatively low pressure: systolic pressure is 15-30 (that is all that’s needed to pump blood to pulmonary circulation b/c short distance and lore resistance path)

3- left ventricle (has to pump blood through systemic circulation- long distance and high resistance path, pumps blood against gravity from heart to head): left ventricular wall is much thicker, contracts and generates much higher force, 100-140 mmHg

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15
Q

pressure in heart is measured in this unit

A

mm Hg

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16
Q

cardiac muscle is so thick that ie needs its own blood supply…

A

coronary arteries form extensive complex that feed blood to cardiac muscle

  • cardiac muscle has high density of mitochondria, so generates ATP efficiently through oxidative phosphorylation- but need constant supply of oxygen to keep it going (O2 supplied by coronary arteries)
17
Q

what issue accompanies the fact that coronary arteries supply oxygen to the heart

A

puts heart in danger of heart attack- occurs when one of the arteries becomes blocked –> blood flow cut off and muscle cells begin to die –> patch of dead cardiac muscle fibers, disrupts ability of heart muscles to communicate and disrupts ability of heart to contract and relax as a unit –> enter fibrilation

18
Q

cardiac muscle has to contract rhythmically and continuously for a lifetime; metabolically, it is most similar to this fiber in skeletal muscle, ___

A

fast phase oxidative

19
Q

how to treat a heart attack based off if its caught early vs. late:

A

if caught early: do balloon catheterization –> expands artery and insert a stent, gives structural support and prevents artery from collapsing, restores bloodflow

if caught late when the artery is entirely blocked: do bypass (vein from leg attached to artery, restores blood flow to cardiac muscle)

20
Q

describe the effects of having a heart attack in the right vs. left ventricle

A

if have heart attack in right ventricle and 30% of cardiac muscle in RV is damaged –> can survive easily b/c right ventricle only has to pump blood to lungs and back, short distance, so even with only 70% of muscle working, can still generate enough pressure to pump blood to lungs

if have 30% damage to left ventricle –> very bad and probably fatal (a lot less tolerance b/c LV has to pump blood through long distance and high resistance path, needs all the muscle to work to accomplish this)

21
Q

what is a developing approach to treat the heart?

A

use pluripotent stem cells to grow a patch of cardiac myocytes in vitro –> transplant patch to damaged area and have healthy cardiac cells fuse with damaged cells, replacing the tissue

22
Q

describe heart worms in animals

A

heart worms happen/grow in the right ventricle b/c they are endoparasites, these parasites have evolved in an anaerobic (low oxygen) environment (and RV has deoxygenated blood)

23
Q

describe properties of the heart that classify it as modified skeletal muscle

A

striated, has sarcomeres, horizontal & vertical patterns, has lots of mitochondria

  • has SR (more well-developed than smooth muscle, but not as well-developed as skeletal)
  • muscle membrane of sarcolemma has voltage-gated calcium channels (diff than skeletal)
  • fibers not anchored at either end, so doesn’t contract linearly, but spiral-y –> allows for greater sarcomere shortening & relaxation
24
Q

what property of cardiac muscle allows adjacent cardiac muscle cells to communicate?

A

cardiac muscle has intercalated discs- points of connection & communication b/w 2 adjacent cardiac muscle cells

  • characterized partly by gap junctions, transmembrane proteins allowing direct ionic current from one cell to another
  • also characterized from desmosomes- connect membranes of each cell, so that when one cell contracts, force contracts in other cell
25
Q

cardiac muscle is similar in molecular organization to skeletal muscle

A

sarcomere organization very similar (sarcomeres laid end to end in myofibrils- extensive T-tubule system)

  • double helix F-actin polymer, capped off at leading end by tropomodulin, anchored at z-line by alpha-actinin
    . support by scaffold of nebulin (like skeletal muscle)
    . has troponin-tropomodulin complex masking binding sites for myosin (troponin has TnC- activated by calcium, like skeletal)
  • myosin is the same- light meromyosin tail forms core; heavy meromyosin head: myosin ATPase, essential and regulatory light chains, also has C protein that acts like a M-line, runs down middle of sarcomere to keep myosin in proper orientation
    . myosin anchored to z-line by spring-like titin
26
Q

what is the pacemaker of the heart

A

SA node

27
Q

although the heart beats all together as a unit, the cell types of the heart beat at their own intrinsic rate and they are not always the same…

A
  • SA node (junction b/w vena cava and right atrium) : group of modified muscle cells, can’t contract but can generate APs - discharge at 70 beats/min (measured in pulses/min b/c can’t really contract)
  • atrial muscle cells: 40 beats/min
  • ventricles: 25 beats/min

but all together, intact heart beats at 70 beats/min, the pace is set by the fastest-beating cells of the SA node (pacemaker of heart), causes other cardiac muscle cells to depolarize prematurely and contract at the faster rate

28
Q

the heart is ___, AP that starts contraction originates in muscle itself

A

myogenic

29
Q

how does the SA node depolarize?

A
  • SA node generates spontaneous depolarization & spontaneous AP (identical to myogenic nature of smooth muscle membrane) - goes from -60 mV (resting) to threshold
  • no steady muscle contraction –> funny sodium channels, slowly leaking sodium in to depolarization & closer to threshold
  • when get closer to threshold, recruits T-type (transient) calcium channels - further depolarizes membrane
  • when reach threshold, activates L-type calcium channels –> responsible for wave of depolarization of AP
  • calcium current is a little slower than the typical-voltage gated, goes to about +20 mV –> at peak, L-type calcium channels close and typical voltage-gated potassium channels open and repolarize membrane
  • called a “slow-response AP”
  • the pacemaker potential (SA node potential)- pacemaker potential starts in SA node and spreads to membranes of other cells, causing them to depolarize pre-maturely, causes whole heart to contract simultaneously
30
Q

in the other cardiac myocytes (other than SA node), what is the resting potential and why?

A

resting potential is -90 mV b/c in cardiac muscle membranes, the permeability of K+ is 100 times greater than permeability of sodium (not 30 x greater)

  • at rest, for every 1 sodium that diffuses in, 99 sodium diffuse out –> brings membrane potential to actual equilibrium potential of K+ (-90 mV)
31
Q

AP is generated on the other cardiac myocytes (as opposed to SA node) differently

A

4 phases:
- phase 4: equivalent to rest (at beginning & end), not stable resting potential b/c inward funny sodium and outward K voltage-gated channels (K diffusion masks funny sodium b/c K+ much faster (permeability is 100x greater), keeps resting near -90 mV

  • phase 0: activation of traditional voltage-gated sodium channels (activated from AP from SA node), this is what causes steep and rapid wave of depolarization (from -90 to +20), open quickly and close quickly –> Na channels deactivate
  • as potential approaches 0, recruits L-type calcium channels (inward calcium helps with steep wave of depolarization)
    . once L-type opens, they close very slowly (stay open long time) –> no rapid repolarization, longer period where membrane of muscle cells stay depolarized
    . 2 opposing forces working during phase 1: inward depolarizing calcium, but also around +20, begin to open outward repolarizing K+ channels (max overshoot lasts ~300 ms)
  • during plateau phase (phase 2), 2 opposing forces balance each other, get max plateau of overshoot –> after 300 ms and end of phase 2, calcium channels close and K+ causes repolarization
  • phase 3: only K+ open and repolarize back to -90 mV
32
Q

explain the rectifying K+ current

A

inward rectifying K+ current (rectifying means “compensating for”- compensates for inward sodium current

  • at +20 mV, specific K+ channel opens and causes an early repolarization, brings potential back down to 0, (transient K+ channels), open quickly and then close … at same time, L-type calcium open- large increasing inward movement of calcium, keeps membrane depolarized (these 2 balance out)
  • begin to open delayed rectifying K+ channels, 2 types: Ks (slow) and Kr (rapid) - these tend to repolarize the membrane … at same time, inward rectifying K+ channels (K1) allow some K+ to flow “backwards” across the membrane, contributing to depolarization - this inward current compensating for outward current, this is like a typical voltage-gated K+ channel, but it does something weird:
    . initially, K+ moves out, but this drags with it- magnesium & polyamines which blocks/stops any more K+ from moving out (so this current allows for backflow of K+, but only a little)
33
Q

during depolarization in cardiac myocytes other than SA node, at the end of phase 2, ____ channels close and ___ channels open full blast (…)

A

L-type calcium close
K channels (K1 channels reverse again and allow outward movement of K+)

34
Q

during depolarization in cardiac myocytes other than SA node, in phase 3, ___ channel open and allow…

A

3 types of K+ channels open, allow outward rapid movement of K+ (delayed rectifying- Kr and Ks) and K1 (now again allowing outward K+ diffusion)

35
Q

during depolarization in cardiac myocytes other than SA node, in phase 4, at rest, the ___ channel dominates

A

outward K1 channel

36
Q

when the K1 channel is open and moves K+ out and drags magnesium & polyamines with it, what else can do this?

A

intracellular spermine, spermidine & putresceine can also cause rectification like magnesium

37
Q

how long does complete cycle of contraction and relaxation last in cardiac myocytes?

absolute refractory period

A

AP has steep wave of depolarization, then plateau and repolarization (whole thing takes about 300 ms)
- cardiac muscle cell membrane has absolute refractory period of 300 ms ( ventricular contraction & relaxation is also 300 ms) –> so strict 1:1 relationship of AP and complete cycle of contraction and relaxation (cannot stimulate muscle to contract again until AP is over)

  • no temporal/wave summation in cardiac muscles (also no tetany)
38
Q

mechanism of contraction in cardiac muscle is a hybrid of ___ and ___ muscle

explain

A

smooth & skeletal

AP travels along cardiac muscle membrane- activates voltage-gated calcium channels (activation of sarcolemma calcium channels –> calcium-induced-calcium release, calcium sparks add together and produce calcium signal –> calcium binds troponin and disinhibits actin filament, and activates myosin ATPase –> contraction

  • relaxation occurs when calcium cleared from cytoplasm (SERCA pumps calcium back into SR … at same time, calcium-sodium exchange protein that moves calcium out and sodium in –> sodium gradient established by sodium pump, large gradient on outside –> sodium then comes in which pushes calcium out