Exam 4 Flashcards
What are the components of the Urinary System?
Kidneys, Ureters, Bladder, Urethra
Function of the Urinary System
Excretion: getting things out of blood
Elimination: getting things out of the body
Homeostasis: maintain fluid balance
What part of the urinary system produces urine( excretion)
Kidneys
What part of the urinary system carries urine outside of the body (elimination)?
Urethra
What organs are classified as retroparitineal?
*THINK SADPUCKER
Super Renal glands Aorta Duodenum Pancreas Ureters Colon (partial) Kidneys Esophagus Rectum
Be able to Trace the flow of urine
Glomerulus—>
proximal convoluted tubule (PCT) → nephron loop (descending → ascending) → distal convoluted tubule (DCT) → connecting tubule → collecting duct → renal papilla → minor calyx → major calyx → renal pelvis → ureter → urinary bladder → urethra
Drains fluid in
Ureters
Drains fluid out
Urethra
Folds of the bladder are called?
Rugae
Bladder fills from _______ ___
Why?
Bottom up
Due to the amount of room in bladder. More room on bottom of bladder- linguistics!
Be able to trace blood flow to kidneys?
- Renal Artery
- Sagmental arteries & veins
- Lobar arteries and veins
- Interlobular arteries & veins
- Arcuate arteries & veins
- Cortical radiate arteries(interlobular) & veins
- Afferent arteriole
- Glomerulus
- Efferent arteriole
A. Leads into peritubular capillaries (always)
B. Vasa recta (sometimes)
This is driven by pressure
Filtration
Filtration is moving from _______ —-> _______
Blood to filtrate
Or glomerulus to capsule
This is not driven by pressure but involves keeping fluid
Reabsorption
Reabsorption moves _________ to __________
Tubule/nephron to blood
Specifically: tubular fluid –> interstitial fluid—> blood
Driven by concentration gradient
Secretion
Secretion moves _______ to ______
Blood —–> tubular fluid
Or
Perit cap—–> DCT
This limb is permeable to sodium and chloride
Ascending Limb
This limb is permeable to water
Descending limb
As _______ moves out of the ascending limb into the interstitial fluid it draws _______ out of descending limb by osmosis
Sodium and chloride
Water
Where is Urea reabsorbed?
Proximal convoluted tubule (PCT)
When Hydrostatic Pressure is greater than osmotic pressure what happens?
Filtration
Amount of filtration per minute
Glomerular Filtration Rate (GFR)
The plasma concentration of compound/ion when it begins to show up in urine
Renal Threshold
Sodium is ________ transported
Actively
In order for fluid to be filtered it has to get through all 3 of these layers
- Fenestrated capillary (fluid has to fit through pores)
- Basement membrane
- Podocyte: slits.
Aka foot process
Pedicels
Where does filtration take place?
Glomerulus
Where does reabsorption of nutrients take place
PCT
Where does reabsorption of water take place
PCT
Where does secretion take place
…
In the presence of ADH, additional water channels are added in which portion of the nephron
Collecting duct & DCT
Direction of movement for reabsorption
Tubular fluid from PCT to blood in peritubular capillaries
Dieetction of movement for secretion
Blood from peritubular cap to tubular fluid in DCT
Intercellular fluid refers to
Cystol
Extracellukar fluid refers to
Plasma
Lymph
Interstitial fluid
If osmoreceotirs are stimulated due to the increase of sodium in ECF, what is the response?
increase ADH to increase the water retention (?)
A low or acidic PH is due to
A increase concentration of hydrogen ions in solution
The muscular band that acts as a valve permitting VOLUNTARY control of micturition is the
External sphincter
The mucosa of the urinary bladder consists of
Transitional epithelium
Glomerular capillaries are
Fenestrated
Due to sodium gain and increasing ECF volume, natriuretic Peptides cause what response?
Increase sodium loss in urine
Increase water loss in urine
Decrease thirst
Stimulate ADH and aldosterone
…… ?????
ECF
Extracellular Fluid
ICF
Intracellular Fluid
Function of Extracellular Fluid?
Transport to and from cells
Constant cellular environment (maintain homeostasis)
Intracellular Fluid Function
Solve chemical reactions in cell
What is an Anion?
A negative electrolyte
What is a Cation?
A positive electrolyte
Most common anions?
ICF (intracellular Fluid): Hydrogen phosphate and proteins
ECF(extracellular Fluid): Cl-
Most common Cation?
ICF: K+
ECF: Na+
What makes plasma different from interstitial fluid?
Proteins in plasma
What makes plasma similar to interstitial fluid
Both extracellular
How do we get water in?
Foods, liquids, cellular metabolism
How do we get water out?
Kidneys, lungs, skin, intestines
When water input is less than output what is the feedback loop?
Blood Volume decreases
Blood pressure decreases
JG releases renin
Angiotensin I & II: aldosterone
Angiotensin I & II: increase thirst
Angiotensin I & II: ADH
What does Aldosterone do?
Increase reabsorption of sodium which in return increases the water absorption
Targets DCT and CD
What does ADH do?
Retains water by aquaporus on DCT and Collecting Duct
Feedback loop: Sodium too high
Too High: 1. Increase Na+ in ECF 2. Osmoreceptors stimulated 3. Secretion of ADH increases Increase water absorption Increase thirst 4. Water shift from ICF to ECF (fluid comes out of cells) 5. Decrease Na+ concentration 6. Return to Homeostasis
Feedback: Sodium too Low
- Decrease Na+ in ECF
- Osmoreceptors inhibited
- Secretion of ADH decreases
Suppress thirst
Increase water loss - Decrease ECF volume
- Increase Na concentration
- Return to Homeostasis
Feedback loop: increased sodium causing increase blood Volume( BV)
- Na increases in ECF
2 homeostatic response increases water intake and retention - Increase BV
- Increase stretch in Atria
Releases ANH - ANH secretes Na
Less water absorption- more water going out.. decrease BV and BP
CHP ( hydrostatic pressure) > BCOP (osmotic pressure)
Filtration
BCOP(osmotic pressure)> CHP(hydrostatic pressure)
Reabsorption
Feedback loop: increased BV and BP
- Increases Fluid (Increase Na causing increases fluid)
2 increase BV and BP
3 atrial distension stimulates ANP - ANP: Na secretion, increase H2O, decrease thirst, inhibit competing hormones
- Decrease BP and BV
- Homeostasis
Feedback loop: decreased BV & BP
- Loss of fluid: loss of Na causing decreases fluid, decrease BV and BP
- JG cells detect decrease in drop of renal BP
- Secrete renin: activate renin-angiotensin system, ADH and Aldosterone
- Increase Na reabsorption
- Increase H2O reabsorption
- increase thirst
- increase BP = increases BV
- Return to Homeostasis
This diuretic blocks ACE which blocks the production of Angiotensin II… causes a decrease in Aldosterone and decreases activity Na/K exchange pumps
Loop diuretics
This diuretic blocks sodium chloride cotransporters in ascending limb
Thiazides diuretics
PH below 7.35
Acidosis
pH above 7.45
Alkalosis
Where does Hydrogen come from?
- Carbonic acid - metabolism (CO2 produced, converted)
- Lactic Acid - metabolism (too much pyruvate, convert)
- Sulfuric Acid- proteins broken down
- Phosphoric Acid - proteins, DNA breakdown
- Acidic Ketone Bodies - breakdown fats
Respiratory response (quick or slow?)
Takes minutes (very quick)
Renal response (quick or slow?)
Takes hours, very slow
What is the phosphate buffer system?
H3PO4 —> H2PO4 + H+ —> HPO4 + H+ —-> PO4 + H+
H3PO4
Phosphoric Acid
H2PO4
Dihydrogen phosphate
HPO4
Mono Hydrogen phosphate
PO4
Phosphate
If pH is alkaline, carboxal group donates H+ ion.
If pH is acidic amino Acid will accept H+ Ion
Protein Buffer System
Carbonic Acid Buffer System?
CO2 + H2O H2CO3 HCO3- + H+
What is the Respiratory Mechanism?
Burning fat because cannot burn glucose
Creates ketones
Respiratory Acidosis Feedback loop?
Ex: hypovenilation
- Increase CO2 leads to
- Increase H+ which 3.leads to a decrease pH
- Chemoreceptors Stimulated
- Increase Respiratory Rate
Decreases CO2 - Renal Response: Secrete H+, Reabsorb HCO4
Decreases H+ - Increase pH
- Homeostasis
Metabolic Acidosis (loss of bicarbonate)
Example: Diarrhea
- Loss of bicarbonate leads to
- Increase H+ leads to
- Decrease pH
- Stimulates Chemoreceptors
- Increase Respiratory Rate
Decreases CO2 - Renal Response: Secretes H+ and Reabsorbs HCO3
Decreases H+ - increases pH
- Returns Homeostasis
Metabolic Acidosis (loss of Hydrogen)
Example: lactic acidosis, ketone acidosis
- Breakdown and release H+ which leads to
- Increase H+ which leads to
- Decrease pH
- Stimulates Chemoreceptors
- Increase Respiratory Rate
Decreases CO2
6 Renal Response: Secretes H+, Reabsorbs HCO3
Decreases H+ - Increase pH
- homeostasis
Respiratory Alkalosis
Example: Hyperventilating
- decrease CO2 leads to
- Decrease H+ leads to
- increase pH
- inhibits Chemoreceptors
- decrease Respiratory Rate
Increases CO2 - Renal Response: Reabsorbs H+ and Secretes HCO3
Increases H+ - Decreases pH
- Homeostasis
Metabolic Alkalosis
Example: Vomiting
- Loss of gastric acid leads to
- Decrease H+ leads to
- Increase pH
- inhibits Chemoreceptors
- decrease Respiratory Rate
Increases CO2 - Renal Response: Reabsorbs H+ and Secretes HCO3
Increases H+ - Decreases pH
- Homeostasis
What are the steps of the Urinary Mechanisms to acidify urine involving secretion of H+
Located in DCT & CD
- CO2 moves from capillaries to DCT Cells
- This forms carbonic acid
- Carbonic Acid Dissociates
- Releases H+ to urine
- Phosphate binds to Hydrogen
- Sodium goes back into cell
- Binds to bicarbonate
- Returns to blood
What are the steps of urinary mechanism to acidify urine involving sodium exchange pumps
If blood is acidic, exchanges more H+ for excretion of urine
What are the steps of urinary mechanism to acidify urine involving ammonia
Located in DCT & CD
- Amino acid goes into cells
- Amino acid is then converted into ammonia
- Ammonia moves into tubule
- Displace Salt
- Ammonia binds to Cl- and excepts hydrogen- excreted
- Na+ moves into cell
- Binds to bicarbonate –> back to blood
Myogenic Mechanism (high BP) feedback loop
- Increase Renal BP
- Increase GFR
3 Constrict Afferent Arterioles - Decrease Blood Flow= Decrease GFR
Tubuloglomerular feedback loop (low BP)
- Decrease Renal BP
- decrease GFR
- Constrict Efferent Arterioles, Stimulate JG Cells( Renin Angiotensin System Activated),
Keep More Na+ & Cl- (decrease water to blood) - Increase HP= Increase GFR
Whether Referring to Respiratory or metabolic Alkalosis, what are the responses?
Renal: generation of Hydrogen ions, and secretion of bicarbonate
Respiratory: inhibit Chemoreceptors to decrease respiratory Rate
_______ may cause respiratory alkalosis, while ______ may cause respiratory acidosis
Hyperventilation; Hypoventilation
Metabolic acidosis may be caused by
Too few hydrogen ions, or too many bicarbonate ions
The major anion in extracellular fluid is what, while the major intercellular anion is what
Chloride, biphosphate
Which of the following hormones play a major role in mediating fluid electrolyte balance?
ADH, ANP, & Aldosterone
Atrial Natriiuretic Peptinde hormones
Reduces thirst
Blocks Aldosterone release
Blocks ADH release
Hypoventilation would cause
Respiratory Acidosis
Prolonged vomiting can result in
Metabolic Alkalosis
The lungs respond to metabolic Alkalosis by __________
Decreasing Respiratory Rate
The kidneys respond to respiratory Acidosis by
Both excreting Hydrogen ions and generating bicarbonate ions
There are how many primary buffering systems in the body?
3
Identify the parts of the kidneys that secrete Renin and EPO.
Renin: secreted from juxtaglomerular kidney cells
Epo: is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and proximal convoluted tubule
Identify the type of epithelium found in the ureters and urinary bladder.
Ureters - transitional epithelium
Bladder - transitional epithelium
Proximal urethra - transitional epithelium
Mid-urethra (males) - stratified and pseudostratified columnar
Distal urethra - stratified squamous epithelium
Explain what occurs in fluid shift and identify its driving force.
Increasing the ECF solute content can be expected to cause osmotic & volume changes in the ICF - a shift of water out of the cells. Conversely, decreasing ECF osmolality causes water to move into the cells, Thus the ICF volume is determined by the ECF solute concentration.
Explain hyperkalemia and hypokalemia.
Hyperkalemia: too much potassium in the body.
Hypokalemia: not enough potassium in the body.
the chemical processes that occur within a living organism in order to maintain life
Metabolism