Exam 4 Flashcards
Parkinson’s Disease
Chronic neurodegenerative disease
Damage to dopamine production - lack of dopamine
Imbalance of dopamine and acetylcholine
Lewy bodies: Clumps of proteins
Characteristics of Parkinson’s Disease
TRAP
Tremors - pill rolling
Rigidity: - cogwheel rigidity, jerky movements
Akinesia - loss of voluntary movement, bradykinesia
Postural instability - Propulsive gait
Parkinson’s Disease tx
Levodopa carbidopa: Dopamine
Dementia
Slower onset degenerative disease
- Infection, trauma, heart disease
Alzheimer’s Disease patho
Chronic progressive neurodegenerative disease
Build up of (amyloid) plaques and neurofibrillary tangles
Rheumatic Diseases patho
Inflammation from immune systems autoimmune response, mistaking own tissue as harmful stimuli
Degenerates joints, muscles, and soft tissue
Osteoarthritis
Progressive deterioration of cartilage in joints
AKA Degenerative joint disease
Labs that indicate Osteoarthritis
Increased ESR (Sed rate) and C-reactive protein
Rheumatoid Arthritis
Systemic rheumatoid disease
Rheumatoid factors attack healthy tissue
Inflammation in synovial joints
Gout
Systemic inflammatory disease
Malfunction in purine metabolism - uric acid crystals damage joints
Labs that indicate Gout
Increased uric acid
Increased BUN/Creatinine
Foods high in purine
Red meat/poultry
Fish
Alcohol
Soda
Lyme Disease
Spirochete (tick) transmitted by deer tick
Bullseye rash 3-30 days after tick bite
Untreated Lyme Disease s/sx
Heart block
Joint pain/arthritis
CNS - memory loss, numbness/tingling
Fatigue
Lyme Disease tx
Oral Doxycycline
IV Rocephin
Septic Arthritis
Infection in joint or joint replacement
Commonly MRSA
Transmitted through cut/incision
Ankylosing Spondylitis
Chronic inflammation
- Effects joints in spine, hips, knees, shoulders
Psoriatic Arthritis
Starts as Psoriasis
Destruction of joint, tendons, ligaments, nails
Systemic Lupus Erythematosus patho
Autoimmune process that effects DNA/RNA
Can cause organ failure
Systemic Lupus Erythematosus s/sx
Butterfly rash
Fever, malaise
Joint inflammation
Kidney failure
Reynaud’s disease
Pain
Systemic Sclerosis
AKA Scleroderma
Autoimmune disease of connective tissue
- Similar to Lupus
Polymyositis and Dermatomyositis
Autoimmune inflammatory disease that causes symmetrical proximal muscle weakness
Polymyositis and Dermatomyositis s/sx
Butterfly rash (like Lupus)
Difficulty raising head
Difficulty going up stairs
Sjogren’s Syndrome
Systemic autoimmune disorder
Effects lacrimal (eyes) and salivary glands
Goes along with other autoimmune disorders
Fibromyalgia patho
Chronic pain syndrome
CNS ascending and descending pathways increase pain signals
Polymyalgia Rheumatica and Giant Cell Arteritis
Disorders that present together
Proximal muscles of arms and legs are affected
Esophageal sphincters
Upper and lower/cardiac sphincters
Stomach sphincters
Upper = cardiac sphincter
Pyloric sphincter
Parietal cells
Release HCl (hydrochloric acid) which secretes Pepsin (digestive enzyme) production
Releases Intrinsic Factor - required for B12 absorption
Pernicious anemia
Lack of B12
Order of small intestines
Duodenum
Jejunum
Ileum
Pancreatic digestive enzymes
Amylase - carbs
Lipase - fats
Pancreas - proteins
Barium swallow
AKA Upper GI series
Looking for lesions, varices, tumors, obstructions
Barium enema
AKA lower GI series
Looking at large intestine for colorectal cancer or polyps
Esophagogastroduodenoscopy (EGD)
Looking at upper GI looking for inflammation
Video Capsule Endoscopy (VCE)
Looks at small intestine for GI bleed, IBS, celiac
Manometry
Tests the pressure and constriction of muscles in the esophagus as you swallow
Electrophysiologic studies
Looks at GI muscle motility and sphincters for peristalsis or spasms
Gastric analysis
Looks at gastric fluid for gastric irritation
- To see if tx is effective or to dx cause
Laparoscopy
Looks at abdominal organs for peritoneal disease, masses, etc.
Types of enteral nutrition
Short term: Nasoenteric tube (NET) or Nasogastric tube (NGT)
Long term: Percutaneous Endoscopic Gastrostomy (PEG/G tube)
Percutaneous Endoscopic Jejunostomy (J Tube)
Complication of enteral nutrition
Dumping syndrome: Rapid emptying of food from stomach to small intestines
- Avoid by watering down formulas
Parenteral nutrition reasons
If GI tract is inaccessible for more than 7-10 days
- Abd surgery, burn, trauma
Locations of parenteral nutrition
Peripheral (PICC)
or Central line (CVC)
Types of formula/solutions for parenteral nutrition
Partial Parenteral (PPN) or Peripheral Parenteral Nutrition (PPN)
Total Parenteral (TPN) or Total Nutritional Admixture (TNA)
Periapical abscess
Infection/pus at the apex (bottom) of tooth
- Tx with aspiration, tooth extraction, ABX, and saline rinse
Periodontitis
Gum inflammation leading to recession (oral thrush)
Tx: Chlorhexadine rinse
Candidiasis
Caused by Candida Albicans yeast
Parotitis
Swelling of your parotid glands (located between ear and jaw)
Caused by virus (mumps/herpes) or Epstein-Barr
Sialadenitis
Inflammation of salivary glands
- Can remove glands for tx
Salivary calculus
Calcium stone in submandibular gland
Tx: Lithotripsy
Erythroplasia
Red lesion
Earliest sign of CA
Glossectomy
Excision of tongue (partial or total)
Tx for CA
What is used to dx GERD
Endoscopy
Barium swallow study
pH monitoring
Medications commonly used for GERD
Antacids - Mylanta
Histamine blockers - Pepcid, Zantac
Proton Pump Inhibitor - Protonix, Prilosec
Types of Hiatial Hernias
Sliding: Stomach bulges upwards
Rolling: (Para-esophageal): Balloons out
Tx for hiatial hernias
Medications: Antacids, PPI (Prilosec), H2 blockers (Zantac)
Surgical: Laparoscopic repair
S/sx of esophageal CA
Dysphagia, pain, bad breath, hiccups, fear of choking, weight loss