Exam 3 Flashcards
Sodium Potassium relationship
Inverse
Calcium/Phosphorus relationship
Inverse
Calcium/Vit D relationship
Similar
Magnesium/Calcium relationship
Similar
Chloride/Bicarbonate relationship
Inverse
Chloride/Sodium relationship
Similar
Third Spacing
Excess fluid where it shouldn’t be
S/sx: Edema, lower BP, high HR
Cations +
Sodium, Potassium, Calcium, Magnesium, Hydrogen
Anions -
Chloride, Bicarbonate, Phosphate/Phosphorus, Sulfate
Hormones that Anterior Pituitary gland secretes
Thyroid Stimulating Hormone (TSH)
Adrenocorticotropic Hormone (ACTH)
Luteninizing and Follicle Stimulating Hormone (LH,FSH)
Prolactin (PRL)
Growth Hormone (GH)
Melanocyte-Stimulating Hormone (MSH)
Posterior Pituitary hormones
Vasopressin/Anti-diuretic Hormone (ADH)
Oxytocin
Baroreceptors
Responds to blood pressure, constricts or dilates vessels by stimulating sympathetic and parasympathetic nerves
Natriuretic peptides
Hormone produced in myocardium that promotes diuresis
RAAS
Kidneys release Renin
Renin splits angiotensinogen into angiotensin I
ACE (lungs/kidneys) splits angiotensin I into angiotensin II
Angiotensin II causes constriction, increased BP, release of aldosterone by adrenal glands
P wave
SA node fires
Atrial Depolarization
PRi
Time from Atrial contraction to Ventricular Contraction
QRS
AV node, Bundle of HIS, and Purkinje fibers fire
Depolarization of Ventricles
Atrial Repolarization (hidden by ventricles)
T
Ventricular repolarization
QTi
Time from ventricles depolarizing to repolarizing
U
Repolarization of Purkinje fibers
How does hyperkalemia show on EKG
Tall T waves
Tx for hyperkalemia
Kayexalate
- IV gluconate or calcium chloride for severe
How does hypokalemia show on EKG
Flattened or inverted T waves
Prominent U wave
How does hypercalcemia show on EKG
Shortened QT - quickly relaxes after QRS
Heart block/dysrhythmias
How does hypocalcemia show on EKG
Prolonged QT
- Takes a long time to relax after QRS
How does hypermagnesemia show on EKG
Peaked T wave
How does hypomagnesemia show on EKG
Inverted T wave
Torsades de Pointes
Exocrine functions of the pancreas
Secretes digestive enzymes (high in bicarb) to neutralize gastric acid
Digests fats, proteins, and carbs
Endocrine functions of the pancreas
Contains islets of Langerhan
Produces insulin or glucagon
Alpha cells
Produce glucagon
Increases blood sugar
Pulls glucose from storage sites and sends into blood stream
Beta cells
Release insulin
Reduces blood sugar
Helps to store glucose in cells and fat cells
Fasting basal insulin (endogenous)
Pancreas releases a steady amount of insulin when you haven’t eaten
Insulin action
Stimulates liver to store sugar as glycogen
Signals liver to stop producing glucose
Moves amino acids into cells
Increases protein and fat synthesis
Promotes storage of triglycerides in fat cells
Where are fatty acids stored?
In fat cells as triglycerides
What happens during prolonged fasting
Insulin production is decreased
Liver and kidneys increase glyconeogenesis
Proteins and fatty acids are broken down into glucose
Blood sugar is maintained between 60-150
What happens when you eat
Insulin released by the pancreas stops glycogen production
Insulin turns excess glucose in the liver into free fatty acids and are deposited as fat in fat cells
T1DM patho
Beta cells are damaged = no insulin production
S/Sx of T1DM
3 P’s
Polyuria
Polydypsia
Polyphagia
T2DM patho
Insulin is less effective at moving glucose into cells
Pancreas produces more insulin, but it cannot be used - insulin resistance
Gestational Diabetes
Onset in 2nd-3rd trimester
Gestational diabetes characteristics
Large at birth, 30-40% of moms within 10 years
Ketone bodies
Without insulin the body breaks down fat cells, ketones are a byproduct
- Excess ketones = Metabolic Acidosis
What type of breathing leads to metabolic alkalosis
Kussmauls breathing - long, deep breaths indicating DKA
- Along with fruity breath
What level of HgA1C indicates DM
Above 6.5
HgA1C for diabetics
Below 7
Normal fasting glucose (with and without DM)
Without DM: Below 100
With DM: 60-110
Normal pre meal glucose (with and without DM)
Without DM: 70-99
With DM: 80-130
Normal post meal (post prandial) glucose (with and without DM)
Without DM: Below 140
With DM: Below 180
Rapid Acting Insulins
Insulin Aspart (Novolog)
Lispro (Humalog)
Insulin Aspart (Novolog) Onset, Peak, Duration
Onset: 5-30 mins
Peak: 30mins-3hrs
Duration: 3-5hrs
Lispro (Humalog) Onset, Peak, Duration
Onset: 10-30mins
Peak: 1h
Duration: 3-5hrs
Short-Acting insulin
Regular human (Humulin R, Novolin R)
Regular human (Humulin R, Novolin R) Onset, Peak, Duration
Onset: 30mins-1hr
Peak: 2-5hrs
Duration: 5-8hrs
Intermediate Acting Insulin
NPH (Novolog N)
70/30 Aspart (Novolog Mix)
75/25 Lispro (Humalog Mix)
NPH (Novolog N) Onset, Peak, Duration
Onset: 1-5hr
Peak: 4-12hrs
Duration: 12-18hrs
Long-Acting insulin
Glargine (Lantus)
Detemir (Levemir)
Lantus/Levemir Peak, Onset, Duration
Onset: 1-4 hrs
Peak: No peak
Duration: 16-24 hrs
When to give rapid-onset insulin
15 mins before meal
When to give short acting insulin
30-60 mins before meal
How to inject/mix insulin
Roll NPH (cloudy)
Inject air into NPH, then Reg
Withdraw Reg, then NPH
Clear before Cloudy
Sick day rules for diabetics
Test BG and ketones Q4H
Supplemental insulin Q4H
Soft foods and liquids to prevent dehydration
Report N/V/D to provider
Dehydration leads to DKA
Acute Pancreatitis patho
Inflammation caused by:
Gall stones
Trauma
Tumors
ETOH
Viral infections
What is the result of acute pancreatitis
Loss of exocrine function - poor digestion
Necrotic pancreas
Labs that indicate acute/chronic pancreatitis
Increased amylase, lipase, bilirubin, and alk phos
Elevated serum BG
Nursing interventions for acute/chronic pancreatitis
Pain control
GI - N/V
Monitor diet
I&O’s - monitor for low albumin/kidney failure
Chronic pancreatitis patho
Progressive destruction of pancreas caused by:
Alcohol, smoking, malnutrition
Chronic pancreatitis s/sx
Severe UQ abd and back pain, weight loss
Chronic pancreatitis tx
Endoscopy to relieve obstruction
Non-opioid pain relief, nerve block
Pancreatic enzymes - malabsorption and steatorrhea
Surgery - if pt refrains from ETOH