Exam 4 Flashcards
Define absorption
Moving substances from the lumen of the gut into the body
Define nutrition
Process of providing of obtaining the food necessary for health and growth
Define metabolism
The sum of:
Anabolism: reactions that build molecules
Catabolism: all processes that break down molecules
Define digestion
Catabolic process that breaks down large food molecules into monomers
Define nutrients vs essential nutrients
Nutrient: substance in food that the body uses for growth, maintenance, and repair
Essential nutrients: those that are needed to be ingested in the diet
Six major nutrient categories
Macro: carbs, protein, fats, water
Micro: Vitamins and minerals
Recommended macronutrient distribution ranges for the 3 macros
Protein: 10-35%
Fats: 20-35% (less than 10 should be saturated)
Carbs: 45-65%
Definition of a calorie
Amount of heat needed to raise one gram of water one degree Celsius.
Calories produced by one gram of each macronutrient
Carbs and proteins: 4 kcal/g
Fats: 9 kcal/g
Empty calories and examples
Calories that contribute to caloric intake but have little nutrition (Alcohol and sugary food)
Fat soluble vitamin definition and list
Absorbed within dietary lipids and are usually stored in the body.
Vitamins A,D,E,K
(K is not stored)
Water soluble vitamin definition and list
Absorbed with water and usually excreted in the urine
Vitamins B and C
Hormone that regulates iron absorption and mobilization
Hepcidin (liver hormone)
What transports iron into the bloodstream
Ferroportin
Protein that stores excess iron
Ferritin
What is iron used for in the body
Hemoglobin synthesis, myoglobin synthesis
Enzyme in oral cavity that begins to process starch
salivary amylase
Three enzymes that break down carbohydrates, description
Dextrinase and glucoamylase: act on oligosaccharides composed of more than 3 simple sugars, break down into monosaccharides
Disaccharides: hydrolyze maltose, sucrose, lactose into monosaccharides
Location of carbohydrate digesting enzymes
The microvilli (brush border) of the small intestine
Three pathways of the aerobic respiration of glucose
Glycolysis, citric acid cycle, electron transport chain
ATP gain from oxidizing one glucose molecule
There is a net gain of 32 ATP per glucose molecule
Main purpose of aerobic respiration of glucose
Generate ATP by breaking down glucose
Summarize the Four important events in glucose oxidation
Glycolysis: breakdown of glucose
Pyruvate processing: anaerobic fermentation
Citric acid cycle: Oxidizes Acetyl CoA to CO2
Electron transport: Establishes proton gradient used to generate ATP
Definition of glycogenesis
Polymerizes glucose to glycogen
Definition of Glycogenolysis
Hydrolyzes glycogen to glucose monomers
Definition of glycolysis
Converts glucose to pyruvic acid
Definition of gluconeogenesis
Forms glucose from noncarb precursors
Enzymes that digest proteins
Peptidases/proteases
Which organ breaks down small polypeptides, what do they become
The pancreas breaks them into oligopeptides
The stomach uses pepsin for what
Breaks protein into small polypeptides
How are oligopeptides broken down into free amino acids
The small intestine brush border breaks down peptides into free amino acids
Purpose of nitrogen balance, downside of negative balance
Nitrogen in equilibrium is necessary for homeostasis, negative balance is associated with muscle atrophy
What causes negative nitrogen balance
If carbohydrate and fat intake are insufficient
Processes in converting amino acids to keto acids
Transamination, oxidative deamination, keto acid modification
Transmination description
Amine group is moved from amino to keto acid
Oxidative deamination description
Amine group of glutamic acid is removed and recombined with CO2 to form urea
Composition of bile
Bile salts, lecithin, cholesterol, proteins.
Bile salt composition
made of bile acids that are often bonded to glycerine or taurine to increase water solubility
Produced in the liver from cholesterol
Steps in lipid digestion
Emulsification, digestion, and micelle formation
Emulsification of lipids process
Bile salts in duodenum break large fat globules down
Digestion of lipids (lipases) process
Pancreatic lipases digest triglycerides into fatty acids and 2-monoglycerides
Micelle formation, purpose
Bile salts aggregate into micelles that incorporate lipid digestion products
Lipoprotein definition
Tiny droplets with a core of cholesterol and triglycerides and a coating of proteins and phospholipids
Purpose of protein coating on lipoproteins
Enables lipids to remain suspended in blood. Acts as a recognition marker for cells that absorb them
Categories of lipoproteins
Chylomicron, VLDL (very low density), LDL, HDL (high)
Summarize lipid transport
- Chylomicrons carry TGs from small intestines into body
- Chylomicron remnant travels to liver for disassembly
LDL deliver cholesterol
HDL delivers cholesterol to liver
VLDL bring more TGs
How are fatty acids oxidized for energy
Glycerol is converted to pyruvate through glycolysis, FAs are beta-oxidized
Pyruvate and fatty acids become Acetyl-CoA. This is converted to ATP through the Krebs cycle
Excess Acetyl-CoA form ketone bodies
brain centers involved in hunger, hormones used
Arcuate nucleus of hypothalamus: Ghrelin, CCK, insulin for hunger. Leptin for satiety
Define lipogenesis, process in the body
Synthesis of fats from other molecules.
Excessive amounts of carbs and amino acids are converted to Triglycerides. When needed for energy, fats enter catabolic pathways.
Short term regulator of hunger
Ghrelin: Secreted when stomach is empty.
Hunger is also stimulated partly by gastric peristalsis
Short term regulators of satiety
Amylin, CCK, Peptide YY. Signal to terminate eating
Long term appetite regulators, role in obesity
Leptin and insulin act as adiposity signals, telling the brain how much adipose tissue is in the body.
Leptin level is proportional to fat storage, leptin insensitivity is a common factor in obesity
Primary vs secondary sex organs
Primary organs produce the gametes (sperm)
Secondary are other organs that are necessary for reproduction
Importance of the scrotum for the testes
Provides a temperatures slightly lower than body temperature, which is needed for the production of sperm.
Dartos muscle role in regulating temperature
Contracts more to decrease surface area and reduce heat loss. Does the opposite to promote heat loss in hot weather.