Exam 3 Review Questions Flashcards
Which of the following statements is not true concerning testing for drugs of abuse?
a) A two-tired testing approach includes screening and confirmatory testing
b) Confirmatory testing must use methods with high specificity and low sensitivity
c) Screening tests detect classes of drugs
d) GC-MS is the reference method used for confirmation
Confirmatory testing must use methods with high specificity and low sensitivity
T/F:
Common routes of exposure to toxins are through the gastrointestinal tract, lungs, and skin.
TRUE
Which of the following is not true concerning analysis of toxic agents?
Correct answer:
a) Screening tests have good specificity but lack sensitivity
b) Confirmatory tests report the concentration of the analyte
c) Screening tests are a rapid test intended to detect the presence of a substance
d) The reference method for most compounds is gas chromatography with a mass spectrometer (GC-MS_
Screening tests have good specificity but lack sensitivity
Toxic levels of acetaminophen are associated with
Hepatotoxicity
Pharmacokinetics and drug concentration are influenced by which of the following factors?
Absorption, distribution, excretion, metabolism
A drug’s most direct and effective method of delivery to its site of action is:
Intravenous administration
A blood draw to determine a peak level of a drug should be drawn:
One hour after an orally administered dose
T/F:
Cytochrome P450 is an enzyme that influences the effectiveness of a drug in an individual.
TRUE
Tumor marker methodology include all of the following except:
a) Immunoassays
b) Gas chromatography
c) Immunohistochemistry
d) Enzyme analysis
Gas chromatography
Which of the following tumor markers is classified as an oncofetal antigen?
Correct answer:
a) Carcinoembryonic antigen (CEA)
b) CA 19-9
c) BRCA-1
d) hCG
Carcinoembryonic antigen (CEA)
Which tumor marker is associated with neuroblastoma?
a) CA-15-3
b) Carcinoembryonic antigen (CEA)
c) CA 125
d) Homovanillic acid (HVA)
Homovanillic acid (HVA)
T/F:
Abnormally low tumor marker concentrations are associated with antigen deficiency and can cause false negative results
FALSE
What is the major transporter of drugs
Albumin
The phenomenon in which a drug is metabolized and results in a reduced concentration of the drug before reaching the circulatory system
First Pass Effect
The study of the biochemical and physiological effects of drugs and their mechanisms of actions:
Pharmacodynamics
This tumor marker is often measured in both total and free form
PSA
The concentration range of a drug within which the drug produces the desired effect
Therapeutic range