Exam 3 Optho Flashcards
Cornea and Sclera
the 4 layers of the cornea are:
squamous epithelium, stroma, descemet’s membrane, and endothelium
T/F: the stroma composes 90% of the corneal thickenss
true
the cornea functions as a _____________ and is a refractive structure of the eye, focusing light onto the ______________.
protective barrier; retina
how does the corneal epithelium contribute to keeping the cornea in a relative state of dehydration?
it pumps fluid. from the cornea into the anterior chamber.
T/F: Defects in the corneal epithelium result in focal corneal edema.
true. because the epithelium normally prevents fluid from entering the cornea via the tear film.
edema can occur from what two general conditions?
epithelial defects (allowing the fluid from the tear film to leak into the cornea) or corneal endothelial dysfunction (due to decreased pump functions)
T/F: the corneal endothelium can regenerate in an adult animal.
False. Extensive loss or degeneration of corneal endothelium results in permanent corneal edema.
Corneal vascularization may occur in response to what diseases?
corneal, scleral, or intraocular
Describe how defects in the corneal epithelium heal (corneal ulcers).
Corneal ulcers heal from adjacent epithelium sliding over the area and then undergoing mitosis to eliminate the defect.
How are corneal stromal defect healing mechanisms similar or different to corneal epithelial defect healing mechanisms?
Stromal defect healing, similar to epithelial, are also covered by sliding and mitosis of adjacent epithelium.
It’s different because fibroblasts (from keratocytes) begin to proliferate and lay down new collagen, though it’s irregularly arranged, forming visible corneal scars)
describe corneal. vascularization
this is where blood vessels grow in from the limbus towards the site of corneal defect.
T/F: Blood vessels in response to surface corneal disease (i.e. ulcer) are typically superficial and are typically straighter.
False. Though the blood vessels are typically superficial in response to surface corneal disease, they undergo branching
Deeper in the cornea, appear much straighter and enter the cornea circumferentially.
This type of corneal vascularization is associated with what type of disease?
intraocular disease
occurs in response to chronic corneal inflammation or irritation.
corneal pigmentation
How is corneal pigmentation associated with corneal vascularization?
Melanocytes, in response to chronic corneal inflammation or irritation, enter the cornea from the limbus in association with corneal neovascularization