Exam 3: Heart Flashcards
1 cause of death in US
Heart disease
Heart disease MC due to
Contractile failure
CHF MC due to
Low cardiac output
Systolic dysfunction
Weak contraction
Diastolic dysfunction
Failed relaxation
Valvular dysfunction
Failure to effectively seal
Forward failure
Insufficient output
Backward failure
Congestion
Forward failure is almost always accompanied by
Backward failure
Forward failure impacts
Virtually every organ
3 adaptations to heart failure
Frank-starling law mechanism
Neurohumoral mechanisms
Structural changes
Frank-starling law
Increase stretch = stronger contraction
Benefit and cost of frank-starling law
Benefit: increase output
Cost: increase O2 and tension
Neurohumoral mechanisms
NE = increase HR and increase contractility
ANP = diuresis and vasodilation
Structural changes
Cardiac hypertrophy
Cost of structural changes
Increase O2 consumption
Pathological cardiac hypertrophy
Concentric hypertrophy
Increase pressure
Physiologic cardiac hypertrophy
Eccentric hypertrophy
Increase volume
Increase capillary density
Athlete’s heart can be used to describe
Sarah
Orthopnea
Dyspnea when lying down
L side heart failure causes L ventricle to
Hypertrophy
L side heart failure causes gradual decrease in ____ and therefore ____
cardiac output
Pulmonary edema
Signs of L side heart failure
Cough
Rales
Orthopnea
Tachycardia
R side heart failure MC from
L sided failure
R side heart failure causes minimal
Pulmonary congestion
R side heart failure causes peripheral congestion, including
Pitting edema
Ascites
Hepatosplenomegaly
30% of all birth defects
Congenital heart disease
As embryo…R atrium communicates with L atrium via
Foramen ovale
As embryo… L pulmonary artery joins aorta at
Ductus arteriosus
___ closes at birth and ____ closes 1-2 days after birth
FO
DA
Risks for congenital heart disease
Prematurity Trisomies Teratogens Maternal diabetes Fetal infection
90% of congenital heart disease are
Idiopathic
Isolated R side heart failure is from
Pulmonary HTN
Pulmonary HTN can be due to
Lung pathology
Valve disorder
Left to right shunt
R side heart failure coming from something in lungs causing pulmonary HTN
Cor pulmonale
Over half of congenital heart disease is due to
Septal defects
VSD or ASD
R to L shunt
Blood bypass lungs —> cyanosis