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Pharmacology > Exam 3 Distinctive Toxicities/side Effects > Flashcards

Exam 3 Distinctive Toxicities/side Effects Flashcards

1
Q

Nausea vomiting diarrhea headache and rare pulmonary fibrosis

A

Nitrofurantoin

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2
Q

Toxic bone marrow suppression and aplastic anemia

A

Chloramphenicol

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3
Q

Nephrotoxicity and hearing loss

A

Vancomycin

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5
Q

Arthalgia/myalgia

A

Quinopristin/dalfopristin

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6
Q

CNS excitement, cartilage damage in children <17

A

Fluoroquinolone

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7
Q

Orange tint

A

Rifampin

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8
Q

Turns urine brown

A

Nitrofurantoin

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9
Q

Phototoxicity

A

Tetracyclines

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11
Q

Blurred vision, altered taste perception, severe hepatotoxicity

A

Telithromycin

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12
Q

Acidic urine will cause sulfonamides to precipitate

A

Methenamine

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13
Q

Affects mammalian DNA too

A

Iododeoxyuridine

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14
Q

Otottoxicity and blocking NMJ

A

Aminoglycosides

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15
Q

Myelosuppression

Less neurotoxicity

A

Vinblastine

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19
Q

Precipitates in acidic urine

A

Sulfonamides

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20
Q

Cardiac toxicity

A

Trastuzumab

Doxorubicin

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21
Q

Nausea, vomiting, cramps, diarrhea, edema, muscle cramps, rash, neutropenia, thrombocytopenia

A

Imatinib

22
Q

Least toxic alkylating agent

A

Chlorambucil

23
Q

Very toxic especially with bone marrow suppression

A

Actinomycin D

24
Q

Just pulmonary fibrosis

A

Bleomycin

25
Q

Hair loss and liver toxicity

A

Cyclophosphamide

26
Q

Decreased metabolism of antidepressants

A

Tamoxifen

27
Q

Well tolerated

Wheezing and bronchospasm due to route of administration

A

Zanamivir

28
Q

Gynecomastia, nausea and vomiting

A

Flutamide, leuprolide

30
Q

Prolonged levels in infants leading to hepatotoxicity

A

Cloramphenicol

31
Q

Renal toxicity minimized by mannitol diuresis

A

Cisplatin

32
Q

Chills, headache, depress bone marrow, confusion, behavior changes

A

Interferons

33
Q

Concentration, abnormal dreams, headache, dizziness

A

Efavirenz

34
Q

Light headed, difficulty concentrating

A

Amantidine

35
Q

Headache, dizziness, diarrhea and constipation

A

Dolasetron

Palonosetron

39
Q

Inhibition of cytochrome p450 metabolism increasing 1/2 life of drugs

A

Azoles

Atazanavir, indinavir-protease inhibitors

40
Q

Hair loss with Folinic acid rescue

A

5-FU

42
Q

Renal toxicity when with Aminoglycosides

A

Cephalosporins

43
Q

Edema, thrombophlebitis at infusion site

A

Quinupristin/dalfopristin

45
Q

Induces drug metabolizing enzymes

Increases metabolism of anticoagulants

A

Rifampin

46
Q

Progressive cumulative tremors, weakness and convulsions

Minimal myelosuppression

A

Vincristine

47
Q

Superinfection

A

Tetracycline

Pharmacology (15 decks)

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