Exam 3 Distinctive Toxicities/side Effects

Question 1

Nausea vomiting diarrhea headache and rare pulmonary fibrosis

Answer 1

Nitrofurantoin

Question 2

Toxic bone marrow suppression and aplastic anemia

Answer 2

Chloramphenicol

Question 3

Nephrotoxicity and hearing loss

Answer 3

Vancomycin

Question 5

Arthalgia/myalgia

Answer 5

Quinopristin/dalfopristin

Question 6

CNS excitement, cartilage damage in children <17

Answer 6

Fluoroquinolone

Question 7

Orange tint

Answer 7

Rifampin

Question 8

Turns urine brown

Answer 8

Nitrofurantoin

Question 9

Phototoxicity

Answer 9

Tetracyclines

Question 11

Blurred vision, altered taste perception, severe hepatotoxicity

Answer 11

Telithromycin

Question 12

Acidic urine will cause sulfonamides to precipitate

Answer 12

Methenamine

Question 13

Affects mammalian DNA too

Answer 13

Iododeoxyuridine

Question 14

Otottoxicity and blocking NMJ

Answer 14

Aminoglycosides

Question 15

Myelosuppression

Less neurotoxicity

Answer 15

Vinblastine

Question 19

Precipitates in acidic urine

Answer 19

Sulfonamides

Question 20

Cardiac toxicity

Answer 20

Trastuzumab

Doxorubicin

Question 21

Nausea, vomiting, cramps, diarrhea, edema, muscle cramps, rash, neutropenia, thrombocytopenia

Answer 21

Imatinib

Question 22

Least toxic alkylating agent

Answer 22

Chlorambucil

Question 23

Very toxic especially with bone marrow suppression

Answer 23

Actinomycin D

Question 24

Just pulmonary fibrosis

Answer 24

Bleomycin

Question 25

Hair loss and liver toxicity

Answer 25

Cyclophosphamide

Question 26

Decreased metabolism of antidepressants

Answer 26

Tamoxifen

Question 27

Well tolerated

Wheezing and bronchospasm due to route of administration

Answer 27

Zanamivir

Question 28

Gynecomastia, nausea and vomiting

Answer 28

Flutamide, leuprolide

Question 30

Prolonged levels in infants leading to hepatotoxicity

Answer 30

Cloramphenicol

Question 31

Renal toxicity minimized by mannitol diuresis

Answer 31

Cisplatin

Question 32

Chills, headache, depress bone marrow, confusion, behavior changes

Answer 32

Interferons

Question 33

Concentration, abnormal dreams, headache, dizziness

Answer 33

Efavirenz

Question 34

Light headed, difficulty concentrating

Answer 34

Amantidine

Question 35

Headache, dizziness, diarrhea and constipation

Answer 35

Dolasetron

Palonosetron

Question 39

Inhibition of cytochrome p450 metabolism increasing 1/2 life of drugs

Answer 39

Azoles

Atazanavir, indinavir-protease inhibitors

Question 40

Hair loss with Folinic acid rescue

Answer 40

5-FU

Question 42

Renal toxicity when with Aminoglycosides

Answer 42

Cephalosporins

Question 43

Edema, thrombophlebitis at infusion site

Answer 43

Quinupristin/dalfopristin

Question 45

Induces drug metabolizing enzymes

Increases metabolism of anticoagulants

Answer 45

Rifampin

Question 46

Progressive cumulative tremors, weakness and convulsions

Minimal myelosuppression

Answer 46

Vincristine

Question 47

Superinfection

Answer 47

Tetracycline