Exam 3

Question 1

SITT

Answer 1

Time required for gut contents to be propelled from the pylorus into the large intestine

Question 2

Micelle

Answer 2

An aggregate formed by self association of surfactant molecules in an aqueous mixture

Question 3

Solubilization

Answer 3

Increasing the apparent water solubility of a solute using micelle forming surfactants

Question 4

Absorption rate

Answer 4

The rate at which drug molecules enter the systemic circulation after administration of a drug product by a non IV route

Question 5

Absolute bioavailability

Answer 5

The fraction of an administered dose that is absorbed into the systemic circulation

Question 6

High solubility drug

Answer 6

The entire dose of drug dissolves completely in 250ml or less of water throughout the pH 1-7.5

Question 7

Low solubility drug

Answer 7

More than 250ml of water is required to dissolve the dose at one or more points in the pH range 1-7.5

Question 8

Gastrectomy

Answer 8

Removal of stomach

Question 9

Short gut syndrome

Answer 9

Part of intestine missing

Question 10

Colectomy

Answer 10

Removal of large intestine(partial or total)

Question 11

Sleeve gastrectomy

Answer 11

Removal of the greater curvature of the stomach