Exam 1

Question 1

ASHP definition

Answer 1

Medication use will be optimal, safe, and effective for all people all of the time

Question 2

Biopharmaceutics

Answer 2

The science that examines the interrelationship of the physicochemical properties of the drug, the dosage form in which the drug is given, and the route of administration on the rate and extent of systemic drug absorption

Question 3

Drug delivery

Answer 3

The series of processes beginning with administration of a drug product and ending with drug molecules at the site of action

Question 4

Drug

Answer 4

A chemical compound intended to furnish pharmacological activity or other direct effect in the diagnosis, cure, mitigation,treatment, or prevention of disease

Question 5

Drug product

Answer 5

A mixture of one or more drugs with inactive ingredients (excipients) in an appropriate dosage form

Question 6

Dosage form

Answer 6

Type of drug product

Question 7

Disintegration

Answer 7

The process of tablet or capsule components dispersing in a liquid

Question 8

Dissolution

Answer 8

The process where molecules leave the solid phase (particle) and enter the solution phase(drug molecules surrounded only by solvent molecules)

Question 9

Absorption

Answer 9

Transport of unchanged drug molecules from an absorption site into systemic circulation

Question 10

Distribution

Answer 10

Drug transport between the systemic circulation and body tissues

Question 11

Elimination

Answer 11

Any process that removes parent drug molecules from the body

Question 12

Metabolism

Answer 12

Enzyme mediated chemical degradation of a drug molecule

Question 13

Excretion

Answer 13

Transport of unchanged drug molecules from the systemic circulation to a fluid outside the body

Question 14

Solution

Answer 14

A homogeneous mixture that is prepared by dissolving a solid, liquid, or gas in another liquid and the molecules of the solute or dissolved substance are dispersed among those of the solvent

Question 15

Suspension

Answer 15

A two phase system consisting of a solid material dispersed in a liquid

Question 16

Tablet

Answer 16

Mixture of a solid drug and appropriate excipients by compression

Question 17

Micronization

Answer 17

Reducing the average particle diameter of a powder to a single micron range

Question 18

Solubility

Answer 18

The dissolved concentration of a solute in equilibrium with excess undissolved solute

Question 19

Ion

Answer 19

Atom or molecule carrying an electrostatic charge

Question 20

Electrolyte

Answer 20

Compound that dissociates into ions in solution

Question 21

Non electrolyte

Answer 21

Compound that does not dissociate into ions in solution

Question 22

St

Answer 22

Solubility of weak electrolytes
Total solubility
Total of dissolved non ion and dissolved ion in a saturated mixture

Question 23

S0

S zero

Answer 23

Non ion form concentration

*constant in a saturated mixture

Question 24

Intrinsic solubility

Answer 24

pH independent
Denoted HA
Is lowest value of St

Question 25

Cosolvent system

Answer 25

A mixture of 2 or more miscible liquids used as a solvent

Question 26

Compatible

Answer 26

There are no chemical or solubility changes when mixed

Question 27

Incompatible

Answer 27

There are significant chemical or solubility changes when mixed

Question 28

Complex

Answer 28

Compound formed by non covalent interaction between two or more molecules in solution

Question 29

Cyclodextrin

Answer 29

A cyclic oligomer of glucose

Prepared from corn starch

Question 30

Chelate

Answer 30

Complex of a metal ion with multiple bonds to the chelating agent

Question 31

Resin

Answer 31

An insoluble polymer