Exam 2 Flashcards
Paracellular transport
Transport of a dissolved molecule across an epithelial barrier by moving between two neighboring cells
Transcellular transport
Transport of a dissolved molecule across an epithelial barrier by moving through a cell
Diffusion
The net movement of molecules or atoms from a region of high concentration to a region of low concentration
Partitioning
Diffusion of a solute molecule from one solvent system into a different solvent system
Partition coefficient
The ratio of solute concentration in a nonpolar or oil phase to the concentration in a water (polar) phase at equilibrium
Log P
The base 10 logarithm of the partition coefficient value
Permeability
Refers to passive diffusion through membranes
Solubility
Definition is based on product strength and pH dependent water solubility
Prodrug
Pharmacologically inactive compound that is converted to an active drug in the body
Concentration
Mass of solute/ volume of solution
Uptake(influx)
Transport of a solute molecule from outside to inside the cell
Efflux
Transport of a solute molecule from inside to outside of the cell
Inhibition
A decrease in the rate of carrier-mediated transport of substrate due to the action of another solute
Competitive inhibition
Inhibition due to the presence of another substrate for the same transporter in the solution
Mixed transport
Simultaneous transport of dissolved molecules across an epithelial barrier by passive and carrier mediated processes
Deglutition
Swallowing
Nasogastric tube
A catheter inserted through the nose and esophagus into the stomach
Nasojejunal tube
A catheter inserted through the nose and esophagus into the jejunum
Gastrostomy tube
A catheter inserted through the abdominal wall into the stomach
Jejunostomy tube
A catheter inserted through the abdominal wall into the jejunum
Esophagitis
Inflammation of the esophageal mucosa
