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Pharm > EXAM 3 > Flashcards

EXAM 3 Flashcards

1
Q

What is the trade name for Atorvastatin?

A

Lipitor

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2
Q

What is the therapeutic class for Atorvastatin?

A

Antihyperlipidemic

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3
Q

What is the therapeutic use for Atorvastatin?

A

Reduction of LDL & cholesterol

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4
Q

What is the pharm class of Atorvastatin?

A

HMG-CoA reductase inhibitor

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5
Q

What is the MOA of Atorvastatin?

A

Reduction of synthesis of cholesterol in liver; increase in LDL receptors in liver

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6
Q

What is the trade name for Cholestyramine?

A

Questran

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7
Q

What is the therapeutic class for Cholestyramine?

A

Antihyperlipidemic

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8
Q

What is the therapeutic use for Cholestyramine?

A

Reduction of cholesterol

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9
Q

What is the pharm class of Cholestyramine?

A

Bile acid resin

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10
Q

What is the MOA of Cholestyramine?

A

Prevent enterohepatic recycling of bile acids, increasing elimination of cholesterol

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11
Q

What is the trade name for Ezetimibe?

A

Zetia

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12
Q

What is the therapeutic class for Ezetimibe?

A

Antihyperlipidemia

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13
Q

What is the therapeutic use for Ezetimibe?

A

Adjunct to therapy with statin to reduce LDL

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14
Q

What is the pharm class of Ezetimibe?

A

Cholesterol absorption inhibitor

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15
Q

What is the MOA of Ezetimibe?

A

Inhibits intestinal absorption of cholesterol

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16
Q

What is the trade name for Gemfibrozil?

A

Lopid

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17
Q

What is the therapeutic class for Gemfibrozil?

A

Antihyperlipidemic

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18
Q

What is the therapeutic use for Gemfibrozil?

A

To reduce triglycerides & VLDL, and increase HDL

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19
Q

What is the pharm class of Gemfibrozil?

A

Fibric acid agent

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20
Q

What is the MOA of Gemfibrozil?

A

Decreases conversion of cholesterol to VLDL, and increase lipoprotein lipase synthesis

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21
Q

What is the trade name for Nicotinic acid (vitamin B)?

A

Niaspan

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22
Q

What is the therapeutic class for Nicotinic acid (vitamin B)?

A

Antihyperlipidemic

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23
Q

What is the therapeutic use for Nicotinic acid (vitamin B)?

A

Treatment of hyperlipidemia not responding to diet & weight loss; to slow progression of coronary artery disease (CAD) when combined with a bile acid sequestrant

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24
Q

What is the pharm class of Nicotinic acid (vitamin B)?

A

Other antihyperlipidemics; vitamin

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25
Q

What is the MOA of Nicotinic acid (vitamin B)?

A

Inhibits release of free fatty acids from adipose tissue, increases rate of triglyceride removal from plasma, reduces LDL & triglyceride levels and increases HDL levels

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26
Q

What is the trade name for Doxazosin?

A

Cardura

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27
Q

What is the therapeutic class for Doxazosin?

A

Antihypertensive, treatment of benign prostatic hyperplasia (BPH)

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28
Q

What is the therapeutic use for Doxazosin?

A

To treat hypertension; treatment of BPH

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29
Q

What is the pharm class of Doxazosin?

A

Alpha1-adrenergic blocker

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30
Q

What is the MOA of Doxazosin?

A

Selective for Alpha1-adrenergic receptors, thus causes vasodilation; also cause relaxation of smooth muscle around prostate gland

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31
Q

What is the trade name for Enalapril?

A

Vasotec

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32
Q

What is the therapeutic class for Enalapril?

A

Antihypertensive, treatment of heart failure

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33
Q

What is the therapeutic use for Enalapril?

A

To treat hypertension; treatment of heart failure

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34
Q

What is the pharm class of Enalapril?

A

ACE inhibitor

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35
Q

What is the MOA of Enalapril?

A

Inhibits conversion of angiotensin I to angiotensin II, a vasoconstrictor, and decreases production of aldosterone, resulting in decreased renal sodium reabsorption

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36
Q

What is the trade name for Hydralazine?

A

Apresoline

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37
Q

What is the therapeutic class for Hydralazine?

A

Antihypertensive, treatment of heart failure

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38
Q

What is the therapeutic use for Hydralazine?

A

Treatment of hypertension that is refractory to other antihypertensives

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39
Q

What is the pharm class of Hydralazine?

A

Direct-acting vasodilator

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40
Q

What is the MOA of Hydralazine?

A

Relaxes arterial smooth muscle by inhibiting IP3 formation

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41
Q

What is the trade name for Hydrochlorothiazide?

A

Microzide

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42
Q

What is the therapeutic class for Hydrochlorothiazide?

A

Antihypertensive, treatment of edema

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43
Q

What is the therapeutic use for Hydrochlorothiazide?

A

To treat hypertension with edema; also approved to treat heart failure, and nephrotic syndrome

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44
Q

What is the pharm class of Hydrochlorothiazide?

A

Thiazide diuretic

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45
Q

What is the MOA of Hydrochlorothiazide?

A

Decreases reabsorption of sodium in the kidney by inhibiting the sodium/chloride cotransporter in the distal tubule of the nephron

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46
Q

What is the trade name for Nifedipine?

A

Adalat

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47
Q

What is the therapeutic class for Nifedipine?

A

Antihypertensive, treatment of angina

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48
Q

What is the therapeutic use for Nifedipine?

A

To treat hypertension and variant or vasospastic angina

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49
Q

What is the pharm class of Nifedipine?

A

Calcium channel blocker

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50
Q

What is the MOA of Nifedipine?

A

Selectively blocks calcium channels in myocardial muscle and vascular smooth muscle

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51
Q

What is the trade name for Atenolol?

A

Tenormin

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52
Q

What is the therapeutic class for Atenolol?

A

Antianginal; antihypertensive; beta-blocker

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53
Q

What is the therapeutic use for Atenolol?

A

Treatment of heart failure, hypertension, angina, and MI.

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54
Q

What is the pharm class of Atenolol?

A

Selective beta1-adrenergic blocker

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55
Q

What is the MOA of Atenolol?

A

Selectively blocks beta1- adrenergic receptors in the heart; slows heart rate and reduces contractility.

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56
Q

What is the trade name for Losartan?

A

Cozaar

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57
Q

What is the therapeutic class for Losartan?

A

Antihypertensive

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58
Q

What is the therapeutic use for Losartan?

A

Used alone or in combination therapy for treatment of hypertension; treatment of diabetic nephropathy.

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59
Q

What is the pharm class of Losartan?

A

Angiotensin II-receptor blocker (ARB)

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60
Q

What is the MOA of Losartan?

A

Selectively blocks angiotensin II receptors; blocks vasoconstriction, and release of aldosterone due to interruption of the renin-angiotensin-aldosterone system.

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61
Q

What is the trade name for Propranolol?

A

Inderal

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62
Q

What is the therapeutic class for Propranolol?

A

Class II antidysrhythmic; antihypertensive

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63
Q

What is the therapeutic use for Propranolol?

A

Treatment of cardiac dysrhythmia, hypertension, angina, and migraine headaches, and for prevention of MI.

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64
Q

What is the pharm class of Propranolol?

A

Beta-adrenergic antagonist (nonselective)

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65
Q

What is the MOA of Propranolol?

A

Nonselective beta- adrenergic blocker, affecting beta1 receptors in the heart, and beta2 receptors in pulmonary and vascular smooth muscle; reduces heart rate, slows myocardial conduction velocity, and lowers bp

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66
Q

What is the trade name for Digoxin?

A

Digitek

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67
Q

What is the therapeutic class for Digoxin?

A

Positive inotrope

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68
Q

What is the therapeutic use for Digoxin?

A

To increase cardiac output, alleviating symptoms of heart failure & improving exercise tolerance

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69
Q

What is the pharm class of Digoxin?

A

Cardiac glycoside

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70
Q

What is the MOA of Digoxin?

A

Inhibits sodium-potassium ATPase, and increases intracellular calcium concentrations in cardiac cells

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71
Q

What is the trade name for Furosemide?

A

Lasiz

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72
Q

What is the therapeutic class for Furosemide?

A

Antihypertensive, treatment of edema & heart failure

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73
Q

What is the therapeutic use for Furosemide?

A

Treatment of acute heart failure, to remove edema, especially when cardiac output & renal flow are severely diminished

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74
Q

What is the pharm class of Furosemide?

A

Loop diuretic

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75
Q

What is the MOA of Furosemide?

A

Prevents renal reabsorption of sodium & chloride in the loop of Henle

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76
Q

What is the trade name for Lisinopril?

A

Prinivil

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77
Q

What is the therapeutic class for Lisinopril?

A

Antihypertensive, treatment of heart failure

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78
Q

What is the therapeutic use for Lisinopril?

A

Treatment of hypertension, heart failure, and improvement of survival in patients when administered within 24 hours after MI

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79
Q

What is the pharm class of Lisinopril?

A

ACE inhibitor

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80
Q

What is the MOA of Lisinopril?

A

Inhibits angiotensin converting enzyme, decreases aldosterone secretion

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81
Q

What is the trade name for Metoprolol?

A

Lopressor

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82
Q

What is the therapeutic class for Metoprolol?

A

Antihypertensive, beta-blocker

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83
Q

What is the therapeutic use for Metoprolol?

A

To slow progression of HF, & to significantly reduce the long-term consequences of HF

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84
Q

What is the pharm class of Metoprolol?

A

Selective beta1-adrenergic antagonist

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85
Q

What is the MOA of Metoprolol?

A

Decreases cardiac workload by reduction of heart rate (due to selective blockade of beta1-adrenergic receptors)

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86
Q

What is the trade name for Milrinone?

A

Primacor

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87
Q

What is the therapeutic class for Milrinone?

A

Positive inotrope

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88
Q

What is the therapeutic use for Milrinone?

A

Short-term treatment of advanced HF, to immediately increase myocardial contractility & cardiac output

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89
Q

What is the pharm class of Milrinone?

A

Phosphodiesterase inhibitor

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90
Q

What is the MOA of Milrinone?

A

Inhibits degradation of cAMP by phosphodiesterase

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91
Q

What is the therapeutic use for Atenolol in terms of being an antianginal?

A

To reduce/prevent angina pain by lowering myocardial oxygen demand

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92
Q

What is the MOA of Atenolol in terms of being an antianginal?

A

Reduces heart rate & contractility, which decreases myocardial oxygen demand

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93
Q

What is the trade name of Diltiazem?

A

Cardizem

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94
Q

What is the therapeutic class for Diltiazem?

A

Antihypertensive, antianginal, antidysrhythmic

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95
Q

What is the therapeutic use for Diltiazem?

A

To treat angina, by increasing oxygen delivery to myocardium & reducing oxygen demand by myocardium

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96
Q

What is the pharm class of Diltiazem?

A

Calcium channel blocker

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97
Q

What is the MOA of Diltiazem?

A

Dilates both coronary & peripheral vessels, which increases oxygen delivery to myocardium & decreases cardiac workload

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98
Q

What is the trade name of Nitroglycerin?

A

Nitrostat

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99
Q

What is the therapeutic class of Nitroglycerin?

A

Antianginal

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100
Q

What is the therapeutic use of Nitroglycerin?

A

To rapidly terminate angina pain, or to prevent angina pain

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101
Q

What is the pharm class of Nitroglycerin?

A

Organic nitrate, vasodilator

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102
Q

What is the MOA of Nitroglycerin?

A

Dilates veins, reducing venous return, & dilates coronary arteries, providing more oxygen to myocardium

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103
Q

What is the trade name of Reteplase?

A

Retavase

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104
Q

What is the therapeutic class of Reteplase?

A

Thrombolytic (clot-buster)

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105
Q

What is the therapeutic use of Reteplase?

A

Immediate treatment of myocardial infarction (MI), to restore coronary blood flow

106
Q

What is the pharm class of Reteplase?

A

Thrombolytic

107
Q

What is the MOA of Reteplase?

A

Cleaves plasminogen, forming plasmin, which degrades fibrin matrix of thrombus

108
Q

What is the trade name of Amiodarone?

A

Cordarone

109
Q

What is the therapeutic class of Amiodarone?

A

Class III antidysrhythmic

110
Q

What is the therapeutic use of Amiodarone?

A

Treatment of severe atrial & ventricular dysrhythmias; treatment of resistant ventricular tachycardia; treatment of atrial dysrhythmias is patients with HF

111
Q

What is the pharm class of Amiodarone?

A

Potassium channel blocker

112
Q

What is the MOA of Amiodarone?

A

Blocks potassium channels & to a smaller degree sodium channels; slows repolarization, increases duration of action potential, prolongs refractory period

113
Q

What is the trade name for Procainamide?

A

Procanbid

114
Q

What is the therapeutic class of Procainamide?

A

Class Ia antidysrhythmic

115
Q

What is the therapeutic use of Procainamide?

A

Treatment of many types of atrial & ventricular dysrhythmias

116
Q

What is the pharm class for Procainamide?

A

Sodium channel blocker

117
Q

What is the MOA of Procainamide?

A

Blocks sodium channels in myocardium, reducing automaticity & slowing conduction velocity of action potentials; increases duration of action potential, delays repolarization, prolongs refractory period

118
Q

What is the trade name for Propranolol?

A

Inderal

119
Q

What is the therapeutic class of Propranolol?

A

Class II antidysrhythmic

120
Q

What is the therapeutic use of Propranolol?

A

Treatment of atrial flutter & fibrillation, tachydysrhythmia, ventricular dysrhythmias

121
Q

What is the pharm class for Propranolol?

A

Non-selective beta-adrenergic antagonist

122
Q

What is the MOA of Propranolol?

A

Reduces heart rate, slows myocardial conduction velocity, reduces automaticity, prolongs refractory period; reduces excessive sympathetic stimulation of heart

123
Q

What is the trade name for Verapamil?

A

Calan

124
Q

What is the therapeutic class of Verapamil?

A

Class IV antidysrhythmic, antianginal

125
Q

What is the therapeutic use of Verapamil?

A

Treatment of paroxysmal supraventricular tachycardia, supraventricular tachydysrhythmia

126
Q

What is the pharm class of Verapamil?

A

Calcium channel blocker

127
Q

What is the MOA of Verapamil?

A

Slows conduction velocity, prolongs refractory period; decreases contractility; reduces blood pressure & cardiac workload; dilates coronary arteries

128
Q

What is the trade name for Alteplase?

A

Activase

129
Q

What is the therapeutic class of Alteplase?

A

Thrombolytic (clot-buster)

130
Q

What is the therapeutic use of Alteplase?

A

Treatment of CVA due to thrombus; restore the patency of IV catheters (off-label use)

131
Q

What is the pharm class of Alteplase?

A

Thrombolytic

132
Q

What is the MOA of Alteplase?

A

Synthetic form of tissue plasminogen activator (TPA); activates plasminogen, which forms plasmin; plasmin degrades fibrin mesh in clots

133
Q

What is the trade name for Aminocaproic acid?

A

Amicar

134
Q

What is the therapeutic class of Aminocaproic acid?

A

Clot stabilizer

135
Q

What is the therapeutic use of Aminocaproic acid?

A

Reduction in post-operative bleeding; treatment of excessive bleeding due to prematurely dissolving clots

136
Q

What is the pharm class of Aminocaproic acid?

A

Hemostatic/antifibrinolytic

137
Q

What is the MOA of Aminocaproic acid?

A

Inactivates plasminogen, reducing the dissolution of clots

138
Q

What is the trade name for Clopidogrel?

A

Plavix

139
Q

What is the therapeutic class of Clopidogrel?

A

Antiplatelet drug

140
Q

What is the therapeutic use of Clopidogrel?

A

Prevention of thromboembolic events in patients with recent history of MI, CVA, or peripheral artery disease; thrombi prophylaxis in patients with unstable angina, & those receiving vascular bypass procedures & angioplasty

141
Q

What is the pharm class of Clopidogrel?

A

ADP receptor blocker

142
Q

What is the MOA of Clopidogrel?

A

Directly inhibits ADP binding to its receptor, prolonging bleeding time & inhibiting platelet aggregation

143
Q

What is the trade name for Heparin?

A

Heplock

144
Q

What is the therapeutic class of Heparin?

A

Anticoagulant (parenteral)

145
Q

What is the therapeutic use of Heparin?

A

To prevent the enlargement of existing clots & formation or new clots

146
Q

What is the pharm class of Heparin?

A

Indirect thrombin inhibitor

147
Q

What is the MOA of Heparin?

A

Binds to antithrombin III, inactivating several clotting factors, & inhibits thrombin activity

148
Q

What is the trade name for Warfarin?

A

Coumadin

149
Q

What is the therapeutic class of Warfarin?

A

Anticoagulant (oral)

150
Q

What is the therapeutic use of Warfarin?

A

To treat cerebrovascular accidents (CVA), myocardial infarction (MI), deep vein thrombosis (DVT), & pulmonary embolism; prevention of thromboembolic events in high-risk patients; prevention of clot formation in patients with indwelling central venous catheters or prosthetic heart valves

151
Q

What is the pharm class of Warfarin?

A

Vitamin K antagonist

152
Q

What is the MOA of Warfarin?

A

Inhibits action of vitamin K, reducing synthesis of clotting factors II, VII, IX, & X

153
Q

What is the trade name for Cyanocobalamin?

A

Calomist

154
Q

What is the therapeutic class of Cyanocobalamin?

A

Anti-anemia drug

155
Q

What is the therapeutic use of Cyanocobalamin?

A

Treatment of vitamin B12 deficiency anemia, pernicious anemia, megaloblastic anemia

156
Q

What is the pharm class of Cyanocobalamin?

A

Vitamin supplement

157
Q

What is the MOA of Cyanocobalamin?

A

Participates in DNA synthesis; necessary for erythropoiesis

158
Q

What is the trade name of Epoetin alpha?

A

Epogen

159
Q

What is the therapeutic class of Epoetin alpha?

A

Anti-anemia drug

160
Q

What is the therapeutic use of Epoetin alpha?

A

Treatment of anemia in patients with chronic renal failure, & in patients with anemia caused by deficiency in erythropoiesis

161
Q

What is the pharm class of Epoetin alpha?

A

Hemotopoietic growth factor, erythropoietin

162
Q

What is the MOA of Epoetin alpha?

A

Stimulates maturation of erythrocyte stem cells into erythrocytes

163
Q

What is the trade name for Ferrous sulfate?

A

Feosol

164
Q

What is the therapeutic class of Ferrous sulfate?

A

Anti-anemia drug

165
Q

What is the therapeutic use of Ferrous sulfate?

A

Treatment of iron deficiency anemia

166
Q

What is the pharm class of Ferrous sulfate?

A

Iron supplement

167
Q

What is the MOA of Ferrous sulfate?

A

Participates in production of hemaglobin

168
Q

What is the trade name for Filgrastim?

A

Neupogen

169
Q

What is the therapeutic class of Filgrastim?

A

Drug for increasing neutrophil production

170
Q

What is the therapeutic use of Filgrastim?

A

Treatment of neutropenia

171
Q

What is the pharm class of Filgrastim?

A

Myeloid colony stimulating factor

172
Q

What is the MOA of Filgrastim?

A

Increases neutrophil production in bone marrow; enhances phagocytic & cytotoxic function of existing neutrophils; stimulates granulocyte & macrophage proliferation & differentiation

173
Q

What is the trade name for Dopamine?

A

Dopastat

174
Q

What is the therapeutic class of Dopamine?

A

Drug for shock, inotrope

175
Q

What is the therapeutic use of Dopamine?

A

To treat shock; at low doses-treatment of hypovolemic & cardiogenic shock; at high doses-to increase blood pressure

176
Q

What is the pharm class of Dopamine?

A

Nonselective adrenergic agonist; inotrope

177
Q

What is the MOA of Dopamine?

A

At low doses, it selectively stimulates dopamine receptors (kidney), causing renal vasodilation & increased renal blood flow; at high doses it increases the production of norepinephrine (DA is a precursor for NE), causing increased total peripheral resistance & blood pressure

178
Q

What is the trade name for Epinephrine?

A

Adrenalin

179
Q

What is the therapeutic class of Epinephrine?

A

Drug for shock, inotrope, vasopressor agent

180
Q

What is the therapeutic use of Epinephrine?

A

Treatment of anaphylactic shock, increases blood pressure, causes bronchodilation

181
Q

What is the pharm class of Epinephrine?

A

Nonselective adrenergic agonist; vasopressor

182
Q

What is the MOA of Epinephrine?

A

Stimulates alpha-adrenergic receptors, increasing peripheral resistance (blood pressure); stimulates beta1-adrenergic receptors, increasing cardiac output; stimulates beta2-adrernrgic receptors, dilating airways

183
Q

What is the trade name for Norepinephrine?

A

Levophed

184
Q

What is the therapeutic class of Norepinephrine?

A

Drug for shock, inotrope, vasopressor agent

185
Q

What is the therapeutic use of Norepinephrine?

A

Treatment of acute shock (significantly reduces mortality); treatment of cardiac arrest

186
Q

What is the pharm class of Norepinephrine?

A

Nonselective adrenergic agonist; vasopressor

187
Q

What is the MOA of Norepinephrine?

A

Sympathomimetic; binds to both alpha- & beta1-adrenergic receptors, constricts blood vessels & increases heart rate

188
Q

What is the trade name for Normal serum albumin?

A

Albuminar

189
Q

What is the therapeutic class of Normal serum albumin?

A

Fluid replacement agent

190
Q

What is the therapeutic use of Normal serum albumin?

A

To restore plasma volume in hypovolemic shock

191
Q

What is the pharm class of Normal serum albumin?

A

Blood product, colloid

192
Q

What is the MOA of Normal serum albumin?

A

Increases plasma oncotic pressure, drawing water from tissues into plasma

193
Q

What is the trade name for Acetazolamide?

A

Diamox

194
Q

What is the therapeutic class of Acetazolamide?

A

Drug for glaucoma

195
Q

What is the therapeutic use of Acetazolamide?

A

To reduce intraocular pressure in patients with glaucoma

196
Q

What is the pharm class of Acetazolamide?

A

Carbonic anhydrase inhibitor, diuretic

197
Q

What is the MOA of Acetazolamide?

A

Inhibits carbonic anhydrase in renal proximal tubule, decreases sodium reabsorption & proton secretion

198
Q

What is the trade name for Chlorothiazide?

A

Diuril

199
Q

What is the therapeutic class for Chlorothiazide?

A

Antihypertensive, treatment of edema & heart failure

200
Q

What is the therapeutic use for Chlorothiazide?

A

To treat mild hypertension, typically in combination with other antihypertensives; to treat fluid retention due to heart failure & other causes

201
Q

What is the pharm class of Chlorothiazide?

A

Thiazide diuretic

202
Q

What is the MOA of Chlorothiazide?

A

Decreases reabsorption of sodium in the kidney by inhibiting the sodium/chloride cotransporter in the distal tubule of the nephron

203
Q

What is the trade name for Furosemide?

A

Lasix

204
Q

What is the therapeutic class of Furosemide?

A

Antihypertensive, treatment of edema & heart failure

205
Q

What is the therapeutic use of Furosemide?

A

Treatment of acute heart failure, to remove edema, especially when cardiac output & renal flow are severely diminished

206
Q

What is the pharm class of Furosemide?

A

Loop diuretic

207
Q

What is the MOA of Furosemide?

A

Prevents renal reabsorption of sodium & chloride in the loop of Henle

208
Q

What is the trade name for Mannitol?

A

Osmitrol

209
Q

What is the therapeutic class of Mannitol?

A

Miscellaneous diuretic

210
Q

What is the therapeutic use of Mannitol?

A

Treatment of elevated intracranial pressure; maintain urine flow in patients with acute renal failure, or during prolonged surgery

211
Q

What is the pharm class of Mannitol?

A

Osmotic diuretic

212
Q

What is the MOA of Mannitol?

A

Filtered by not reabsorbed in renal glomerulus, increases osmotic Starling force in Bowman’s capsule, increases net filtration of water out of plasma

213
Q

What is the trade name for Spironolactone?

A

Aldactone

214
Q

What is the therapeutic class of Spironolactone?

A

Antihypertensive, treatment of edema

215
Q

What is the therapeutic use of Spironolactone?

A

Treatment of hypertension, typically in combination with other antihypertensives

216
Q

What is the pharm class of Spironolactone?

A

Potassium-sparing diuretic; aldosterone antagonist

217
Q

What is the MOA of Spironolactone?

A

Blocks aldosterone receptors in collecting duct of nephron; inhibits sodium-potassium exchange, increasing sodium excretion, but decreasing potassium excretion

218
Q

What is the trade name for Aldesleukin?

A

Proleukin

219
Q

What is the therapeutic class of Aldesleukin?

A

Immunostimulant

220
Q

What is the therapeutic use of Aldesleukin?

A

To treat renal cell carcinoma; treat metastatic melanomas

221
Q

What is the pharm class of Aldesleukin?

A

Interleukin

222
Q

What is the MOA of Aldesleukin?

A

Activates cytotoxic T cells, increases cytokines & platelet count

223
Q

What is the trade name for Cyclosporine?

A

Neoral

224
Q

What is the therapeutic class of Cyclosporine?

A

Immunosupressant

225
Q

What is therapeutic use of Cyclosporine?

A

To prevent tissue rejection in patients receiving transplant; also used to treat severe cases of ulcerative colitis & Crohn’s disease

226
Q

What is the pharm class of Cyclosporine?

A

Calcineurin inhibitor

227
Q

What is the MOA of Cyclosporine?

A

Inhibits helper T cells

228
Q

What is the trade name for Interferon alfa-2b?

A

Intron-A

229
Q

What is the therapeutic class of Interferon alfa-2b?

A

Immunostimulant

230
Q

What is the therapeutic use of Interferon alfa-2b?

A

To treat hairy cell leukemia, malignant melanoma, non-Hodgkin’s lymphoma, AIDS-related Kaposi’s sarcoma, human papilloma virus, chronic hepatitis virus B & C

231
Q

What is the pharm class of Interferon alfa-2b?

A

Interferon, biologic response modifier

232
Q

What is the MOA of Interferon alfa-2b?

A

Attach to infected cells & signal them to secrete antiviral proteins; increase phagocytosis & enhance cytotoxic T cell activity

233
Q

What is the trade name for Muromonab-CD3?

A

Orthoclone OKT3

234
Q

What is the therapeutic class for Muromonab-CD3?

A

Immunosupressant

235
Q

What is the therapeutic use for Muromonab-CD3?

A

To prevent renal transplant rejection; treat steroid-resistant rejection of heart & liver transplants in adults

236
Q

What is the pharm class for Muromonab-CD3?

A

Monoclonal antibody

237
Q

What is the MOA of Muromonab-CD3?

A

Monoclonal antibody to T cell antigen

238
Q

What is the trade name for Acetaminophen?

A

Tylenol

239
Q

What is the therapeutic class of Acetaminophen?

A

Antipyretic, analgesic

240
Q

What is the therapeutic use of Acetaminophen?

A

Treatment of fever in children; relief of mild to moderate pain when aspirin is contraindicated

241
Q

What is the pharm class of Acetaminophen?

A

Centrally acting COX inhibitor

242
Q

What is the MOA of Acetaminophen?

A

Inhibits prostaglandin synthesis in CNS

243
Q

What is the trade name for Aspirin?

A

Bayer aspirin

244
Q

What is therapeutic class of Aspirin?

A

Antiinflammatory, analgesic, antipyretic

245
Q

What is the therapeutic use of Aspirin?

A

Treatment of fever, pain, and mild inflammatory conditions

246
Q

What is the pharm class of Aspirin?

A

Salicylate

247
Q

What is the MOA of Aspirin?

A

Inhibits prostaglandin synthesis by cyclooxygenase 1 & 2

248
Q

What is the trade name for Celecoxib?

A

Celebrex

249
Q

What is the therapeutic class of Celecoxib ?

A

Antiinflammatory, analgesic

250
Q

What is the therapeutic use of Celecoxib?

A

Treatment of acute & chronic arthritis in adults

251
Q

What is the pharm class of Celecoxib?

A

COX-2 inhibitor, NSAID

252
Q

What is the MOA of Celecoxib?

A

Inhibits prostaglandin synthesis by cyclooxygenase-2

253
Q

What is the trade name for Ibuprofen?

A

Advil

254
Q

What is the therapeutic class for Ibuprofen?

A

Antiinflammatory, analgesic, antipyretic

255
Q

What is the therapeutic use of Ibuprofen?

A

Treatment of mild to moderate pain, fever, & inflammation

256
Q

What is the pharm class for Ibuprofen?

A

NSAID

257
Q

What is the MOA of Ibuprofen?

A

Inhibits prostaglandin synthesis by cyclooxygenase 1 & 2

258
Q

What is the trade name for Prednisone?

A

Sterapred

259
Q

What is the therapeutic class for Prednisone?

A

Antiinflammatory

260
Q

What is the therapeutic use of Prednisone?

A

Treatment of severe inflammation; treatment of neoplasia, asthma, arthritis, corticosteroid deficiency

261
Q

What is the pharm class of Prednisone?

A

Glucocorticoid

262
Q

What is the MOA of Prednisone?

A

Inhibits phospholipase A2, which produces arachidonate, a precursor of inflammatory prostaglandins

Pharm (7 decks)

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