Exam 3 Flashcards
scientific study of muscles
myology
cross-banded appearance of muscle tissue under the microscope
striations
bundles of myofibers
fascicle
muscle cells-long multinucleated muscle cells arranged in parallel to one another within the muscle
myofiber
plasma membrane of a muscle cell.
sarcolemma
cytoplasm of muscle cells
sarcoplasm
smooth endoplasmic reticulum (ER) of muscle cells, SR is well-developed in skeletal muscle myofiber and is wrapped in a highly organized pattern around myofibrils
Sarcoplasmic Reticulum (SR)
repeated expanded sections of the SR that lie adjacent to T-tubules
Terminal Cisternae
narrow membranous tunnels formed from and continuous with the sarcolemma. Function is to transmit action potentials from surface to interior of myofibers
Transverse Tubules (T-tubules)
one T-tubule + two adjacent terminal cisterns of SR
Triad
elongated strands of protein complexes found inside myofibers
Myofibril
what myofibrils are organized into, alternating light and dark zones
Sarcomere
light zones containing thin myofilaments
I-Band
dark zones containing thick myofilaments
A-Band
a dense line composed of a-actinin that attaches the thin myofilaments of adjacent sarcomeres
Z-disk
helps hold the thick filaments in proper alignment, elasticity helps return a stretched sarcomere to its original resting length
Titin
area within the A-band where only thick filaments exist
H-zone
middle portion of H-zone where the tick myofilaments lack myosin heads
Bare Zone
a dark line in the middle of the bare zone that contains proteins that are critical for organization and alignment of the thick filaments
M-line
contain myosin and titin
Thick Myofilaments
contain actin
Thin Myofilaments
a structural protein that lies alongside thin filaments and attaches the thin myofilaments to the Z-disks
Nebulin
filamentous polymer consisting of G-actin subunits arranges in two F-actin strands the twist together to form a helix
F-Actin
contains a myosin-binding site
G-Actin
filamentous protein that lies in the groove between the F-actin strands. Each tropomyosin molecule spans seven G-actin subunits
Tropomyosin
a Ca binding protein that binds at regular intervals along tropomyosin molecules
Troponin
the synapse where the nervous system communicates with skeletal muscles
Neuromuscular Junction (NMJ)
space between the end of the synaptic bulb and that sarcolemma of the myofiber
Synaptic Cleft
a specialized region of the sarcolemma of the myofiber where the synaptic bulb of the a-motor neuron sits. This region of the sarcolemma is made up of a series of membrane folds containing a high density of nicotinic cholinergic receptors
Motor Endplate
on the myofibers are ligand-gated Na, K channels that open when Ach binds to them, allowing Na to flow into the myofiber and K flow out
Nicotinic Receptor
mechanically linked to Ca release channels
Dihydropyridine (DHP) Receptor
Ca release channels
Ryanodine Receptor (RyR)
an enzyme found in synaptic cleft, rapidly degrades Ach. Degradation of the Ach closes the nicotinic receptors and stops end plate potential generation along with the subsequent action potential generation in the sarcolemma.
Acetylcholinesterase
consists of alpha-motor neuron and all of the myofibers (muscle cells) that it stimulates
Motor Unit
muscle movement generated in response to a single action potential moving down an alpha-motor neuron and stimulating the myofibers in its motor unit
Twitch Contraction
O2-storage protein to myofibers
Gives red color
Myoglobin
pathological condition caused by Clostridium tetani toxin
Tetanus “Lock Jaw”
steady state of muscle contraction that occurs when the frequency of stimulation of a muscle increases to point that wave summation results in sustained contraction
Tetanus / Tetany
given skeletal muscle served by a group of alpha-motor neurons, whose cell bodies are grouped together in the spinal cord (or brainstem) to form
Motor Nucleus
Decrease in work capacity of a muscle caused by work itself
Fatigue
extreme fatigue that occurs when ATP is completely depleted in a myofiber
Rigor
stiffening of a dead body that occurs a few hours after death of the animal
Rigor Mortis
serve a function similar to Z-disks in skeletal muscles
Dense Bodies
dense bodies associated with inner surface of membranes of smooth muscle cells
Attachment Plaques / Membrane-dense areas
found in iris and ciliary body of eye, vas, deferens, and arrector pilorum muscles of hair on skin
Multi-Unit Smooth Muscles
allow rapid and precise nervous system control of these smooth muscles
Contact Junctions
“visceral type”- found in walls of viscera (internal organs) 99% of all smooth muscle is this type
Single Unit (Unitary) Smooth Muscle
slow to activate; with this type of smooth muscle. ANS stimulation affects rate and strength of contraction, but is not the primary stimulator of contraction
Diffuse Junctions
a Ca binding protein similar to troponin
Calmodulin
activated by calmodulin. Phosphorylates the myosin light chain called the regulatory chain which is found associated with the myosin head
Myosin Light Chain Kinase (MLCK)
process of adding together individual twitch contractions to increase the overall strength of muscle contraction
Muscle Summation
“steady state of contraction” occurs when frequency of stimulation of a muscle produces almost peak tension during a rapid cycle of contraction and relaxation
Incomplete Tetanus
“steady state of muscle contractions” occurs when frequency of stimulation of a muscle becomes so rapid that no further increase in frequency will increase the tension of contraction
Complete Tetanus
sum of all physical and chemical changes that take place within an organism
Metabolism
all processes in which simpler substances are assembled into more complex substances (requires input)
Anabolism
all processes in which complex substances are broken down into simpler substances (release of energy)
Catabolism
organic compound that can be broken down in the body to produce usable energy
Macronutrient
work that synthesis of new molecules (anabolism)
Chemical Work
work movements of the animal that involve muscle contraction and organelle movement inside cells
Mechanical Work
work by transporting substances across membranes by active transport
Transport Work
passage of digested components of food from lumen of GI tract into the blood for distribution to all the cells of the body
Absorption