Exam 2 Flashcards
atoms or molecules that have gained or lost electrons
Ion
any chemical that can carry electrical charge when dissolved in H2O
Electrolyte
material through which ions can move freely toward each other
Conductor
material that separate oppositely charged ions unable to move
Insulator
potential energy created by difference between amounts of electrical charge present at two points like the inner surface and outer surface of a membrane
Electrochemical Potential
membrane potential when the membrane is ‘resting’ (not conducting electrical impulses)
Resting Potential (Vrest)
change in membrane potential whose magnitude is proportional to stimulus strength
Graded Potential
rapidly moving wave of electrical charge that move along membrane of an active excitable cell
Action Potentials (AP)
channels whose molecular conformation responds to the changes in electrical potential across the cell membrane
Voltage-Gated Channel
stimulus strong enough to initiate an action potential by triggering opening of the activation gate of the voltage-gated Na+ channels
Threshold Stimulus
stimulus NOT strong enough to open the activation gate of the voltage gated Na+ channels and initiate AP
Sub-threshold Stimulus
process of making membrane potential less negative
Depolarization
process of regaining Vrest after depolarization
Repolarization
undershooting Vrest on repolarization due to excess K+ ions, moves membrane further from threshold
Hyperpolarization
brief space of time in which excitable membrane resistant to further stimulation
Refractory Period
short period during and immediately after depolarization where a neuron or myofiber will not respond again to any stimulus, no matter how strong
Absolute Refractory Period
follow absolute refractory period where a neuron/myofiber will only respond to strong stimulus
Relative Refractory Period
spread of actin potential along membrane of excitable cell
Propagation
used in unmyelinated axons and muscle cells
Continuous Propagation
used in myelinated axons
Saltatory Propagation
high lipid content of sheath (excellent electrical insulator)
Myelin
unmyelinated areas of myelinated axon found between myelin sheaths
Nodes of Ranvier
groups of neurons that influence each other’s activity by communicating at neuronal synapses
Neuronal Pathways
site/junction where electrical signals are transmitted from one cell to another
Synapse
found between successive neurons in neuronal pathway
Neuronal Synapse
found between somatic x-motor neurons and myofibers of skeletal muscles
Neuromuscular Junctions
found between autonomic motor neurons and autonomic effectors (smooth muscle & glandular cells)
Neuroeffector Junctions
neuron that carries impulses into synapse
Presynaptic Neuron
neuron that carries impulses away from synapse
Postsynaptic Neuron
two cells forming synapses separated by physical space (synaptic cleft)
Chemical Synapse
narrow space separating presynaptic neuron from postsynaptic neuron
Synaptic Cleft
extracellular signal molecules released by neurons that diffuse across synaptic cleft to stimulate activity in a postsynaptic neuron or effector
Neurotransmitters (NT)
membrane proteins found on postsynaptic neurons that bind a specific NT & generate response in the postsynaptic cell
Neurotransmitter Receptor
depolarizing graded potential brings postsynaptic neuron closer to threshold
Excitatory Postsynaptic Potential (EPSP)
hyper-polarizing graded potential that moves a postsynaptic neuron further from threshold for creating APs
Inhibitory Postsynaptic Potential (IPSP)
process of integrating the input from multiple synapses
Summation
release of NT from more than one synaptic knobs on single postsynaptic neuron
Spatial Summation
stimulation of NT release from same presynaptic knobs in rapid succession on postsynaptic neuron
Temporal Summation
membrane potential of postsynaptic neuron held nearer to threshold then normal but not yet above threshold
Facilitation
signal entering in section of neuronal pathway excites great number signals leaving
Divergent Pathways
signals from multiple input fibers come together to excite single output fiber
Convergent Pathways
carry impulses away from CNS out to motor effectors
Efferent (motor) Neurons
control skeletal muscle contraction
Somatic Motor Neurons
control involuntary effectors
Autonomic Motor Neurons
pupil diameter changes due to contraction of smooth muscle within iris
Pupillary Light Reflex
dilation of pupil response to pain, excitement, & dim light
Mydriasis
fight or flight
Sympathetic Division
rest and repair
Parasympathetic Division
constriction of pupil response to increased light entering the pupil
Miosis
cell bodies found in CNS & axons termination autonomic ganglia where they form synapses (long)
Preganglionic Neuron
cell bodies of neuron found in autonomic ganglia & terminate involuntary effectors (short)
Postganglionic Neuron
activated by acetylcholine
Cholinergic Receptors
ligand-gated Na+ (cation) channel
Nicotinic Receptors
Gprotein coupled receptors that activate production intracellular messengers
Muscarinic Receptors
activated by binding of two catecholamines
Adrenergic Receptors
responds most strongly to NE
x-Adrenergic Receptors
effort to prepare animal for maximal skeletal muscle activity
Fight-or-Flight Response
chemical signals that regulate metabolic activites
Hormones
hormones that regulate release of other hormones
Trophic Hormones
any cell that contains receptors that bind & react to specific hormones
Target Cells