Exam 3 Flashcards
Gametogenesis
Process of formation and development of specialized generative cells (gametes) from bipotential primordial germ cells
When do females begin producing oocytes?
In utero
When do males begin producing sperm?
At puberty
Chromatid
One of two identical halves of a chromosome that has been replicated in preparation for cell division
Centromere
Connect the two sister chromatids together
What forms a zygote?
The fusion of a sperm and egg
Interphase I
Chromosomes replicate + centriole pairs replicate
Meiosis I
Cell division that reduces the chromosome number by half. Separates pairs of homologous chromosomes
Prophase I
Chromosomes condense + homologous chromosomes pair/exchange dna
Prometaphase I
Spindle apparatus forms
Metaphase I
Homologous pairs arranged at metaphase plate (middle of cell)
Anaphase I
Homologous chromosomes are separated + pulled to opposite ends of cell
Telophase I
Nuclear membrane forms
Cytokinesis I
Cytoplasm + cell membrane pinch off around the two new nuclei to form 2 haploid cells
Tetrads
Homologous pairs that carry genes controlling the same inherited traits
Karyotype
Method of organizing the chromosomes of a cell in relation to #, size, + type
Crossing over
Segments of no sister chromatids break + reattach to the other chromatid
What are the sites where cross over occurs called?
Chiasmata (chiasma)
Prophase II
Chromosomes condense + nuclear membrane dissolves
Metaphase II
Spindle fibers attach to chromosomes + they line up in middle of the cell
Anaphase II
Centromeres divide + sister chromatids move to opposite ends of cell
Telophase II + cytokinesis
Chromosomes reach opposite ends + nuclear membrane forms
Meiosis II
Produce 4 haploid daughter cells
What hormones does the pituitary gland produce?
Follicle-stimulating hormone + luteinizing hormone
What hormone is secreted by the hypothalamus?
Gonadotropin releasing hormone (GnRH)
Spermatogenesis
Transformation of spermatogonia into mature sperms
Spermiogenesis
Last step of spermatogenesis. Process of sperm maturation
Spermatogonium
Undifferentiated male germ cell
Spermatogonia type A dark
Do not undergo active mitosis
Spermatogonia type A pale
Undergo active mitosis. Divide to produce type B cells
Spermatogonia type B cells
Divide to give rise to primary spermatocytes
Sertoli cells
Somatic cells of the testes that are essential for testis formation
Spermatogonium
First cells of spermatogenesis
Primary spermatocytes
Enter prophase I + appear larger than spermatogonia
Secondary spermatocytes
Smaller than primary spermatocytes. Enter + complete meiosis II
Spermatids
Immature sperm cells
Spermatozoa
Mature human spermatozoon. Includes tail, head, + neck
Capacitation
capacitated sperms bind to a glycoprotein on zona pellucida during fertilization
How long do ejaculated sperm undergo capacitation for?
7 hours
Oogenesis
Look for video! Slides don’t make sense
Perimetrium
Thin external layer of uterus
Myometrium
Thick smooth muscle. Middle layer of uterus
Endometrium
Thin, internal layer of uterus. Consists of compact layer, spongy layer, basal layer
What do the ovaries produce?
Oocytes + hormones
Follicle stimulating hormone
Stimulates development of ovarian follicles + production of estrogen
Luteinizing hormone
Trigger for ovulation + stimulates follicular cells + corpus luteinizing to produce progesterone
Ovarian cycle
Watch a video
What is a mature follicle called?
Graafian follicle
Menstrual phase
Functional layer of uterine wall is sloughed off due to decreased progesterone. Lasts 4-5 days
Proliferation phase
9 days of follicular growth + endometrial thickness growth. More blood flow to tissue. Increased estrogen + progesterone levels
Luteal phase
Endometrium becomes even thicker. Coincides with formation of corpus luteum
Ischemia phase
Oocytes is not fertilized. Degeneration of luteum. Endometrial lining begins to breakdown
What is the most common site for fertilization?
Ampulla
When does fertilization occur?
12 hours after ovulation
Cleavage
Series of mitotic divisions of the zygote
Blastula
Zygote cytoplasm cleaved to form blastula
What is a morula?
An inner cell mass + outer cell mass formed from blastomeres
Blastocyte
Forms when fluid secreted within the morula forms a cavity
Trophoblast
Outer cell layer of blastocyte. Forms into the placenta
Embryoblast
Inner cell mass of blastocyte
Monozygotic/monoovular
1 fertilized egg splits into 2 developing zygotes. Identical twins, same sex
Dizygotic/polyovular
2 sperm fertilize 2 ova. No identical twins
Triploidy
3 pronuclei within 1 zygote
Blastogenesis
3 days after fertilization morula forms + enters uterus. Cavity forms into morula converting it into the blastocyte
Zona pellucida functions
Prevents premature implantation
“Hatching”
Zona pellucida opens allowing blastocyst to implant
Embryoblast
Inner cells of blastocyst
Trophoblast
Outer cells of blastocyst. Engulfs + destroy cells of uterine lining creating blood pools
Early pregnancy factor (EPF)
Immunosuppressant. Released by trophoblast. Used to determine pregnancy
Cytotrophoblast
Inner layer of trophoblast
Syncytiotrophoblast
Outer layer of trophoblast. Multinucleated protoplasmic mass. Hydrolytic enzymes. Secretes human chorionic gonadotropin
What does human chorionic gonadotropin do?
Stimulates corpus luteum to produce progesterone
What is the most common site of implantation in ectopic pregnancy?
fallopian tube
Embryoblast differentiation
Inner cell mass subdivides into the bilaminar disc
What does the epiblast form?
The embryo + extra-embryonic epithelial membrane
What does the hypoblast form?
The primary yolk sac
Day 8 after implantation: syncytiotrophoblast
WRITE OUT PROCESS IN PICTURES (END OF PWRPNT 2).
Where does extrauterine implantation occur?
Tubes, abdominal cavity,
Abortion
Premature stoppage of development + expulsion
Threatened abortion
Bleeding, possible abortion. 25% pregnancy complications
In threatened abortion, what percent of people do abort?
50%
Spontaneous abortion
Natural occurrence before 20 weeks. Most common during 3rd week
In threatened abortion, what percent of people do abort?
25-30%
Habitual abortion
Spontaneous expulsion of embryo in 3 or more consecutive pregnancies
Induced abortion
Birth that is medically induced before 20 weeks
Complete abortion
Everything is expelled (fetus + fetus membranes)
Missed abortion
Retention of concepts in the uterus after death of the embryo
Intrauterine fetal demise
Death of fetus after 20 weeks. AKA still birth
Trilaminar disc
Forms in week 3
Gastrulation
Process where 3 germ layers are established in the embryo
what does the ectoderm become?
Becomes the epidermis, CNS/PNS + many connective tissues of head
what does the mesoderm become?
Becomes skeletal muscle, blood cells, smooth muscle, serosal linings + most of cardiovascular system. All connective tissue in TRUNK ONLY
what does the endoderm become?
Becomes epithelial linings of respiratory + alimentary tract, pancreas + liver
What does the endoderm, ectoderm, + mesoderm form from?
Epiblast
Primitive streak
Thickened linear band of epiblast appears. Creates craniocaudal axis
Functions of notochord
Provides structure, skeletal foundation of vertebral column, forms the neural tube
Cloacal membrane
Caudal to primitive streak + site of future anus
What are the layers in the oropharyngeal membrane?
Ectoderm + endoderm
Oropharyngeal membrane
Becomes the mouth
Where do you only find endoderm + ectoderm?
Oropharyngeal membrane, median plane (cranial to primitive node), cloacal membrane
Neural induction
Signals from the notochord telling ectoderm to become nervous system
Formation of neural tube
Neural plate folds to become the neural crest. Neural crest closes off to form neural tube
Closure of the neural tube
Closes cranially first, then caudally
Step by step of neurulation
- Notochord
- Neural plate
- Neural groove
- Neural tube
- Neural crest cells
Neural crest cells
Migratory cells. Give rise to spinal ganglia + ganglia of ANS. Becomes neurolemma (Schwann cells)
How many somites are there in an embryo?
42-44
What 3 categories do the somites develop into?
sclerotome, myotome, + dermatome
What does the sclerotome become?
Vertebrae + ribs (axial skeleton)
What does the myotome become?
Muscles
What does the dermatome become?
The skin
What is the placenta?
Primary site of nutrient + gas exchange between mother + fetus
Fetal part - placenta
Develops from chorionic sac (EEMD)
Maternal part - placenta
Derived from the endometrium
Functions of maternal placenta
Protection, nutrition, respiration, excretion, + hormone production