Exam 3 Flashcards
figures in early pharmacology (medieval)
- Hippocrates: father of medicine; wrote Hippocratic corpus detailing using the 4 humors to find bodily sources of disease; recorded many plants including purgitives and emetics
- Diascorities: wrote Materica Medica containing illustrations (some misinterpreted); specific information like time of day for opium harvest
- Aristotle: philosopher; made list of medicinals
- Galen: standardization of medicine and dosage
- Theophrastus: botanist who emphasized opium for pain
- Hans Weiditz: wrote Spiegel der Artzney (medical handbook)
Galenic preparations
- dry medicine: tablets, capsules, powderes
- liquid medicine: teas including infusions (water or oil), decoctions (water), tinctures (alcohol), extracts (other solvents)
medicine in the Roman empire
- Greek physicians given Roman citizenship
- many “rhizotomi”–people who were plant experts and assisted physicians who lacked botany experience (slaves, old women)
general medieval medical history
- fall of Constantinople disrupted trade, esp spice
- church dogma–witch burning and torture
- belief in doctrine of signatures (sympathy): plants resembling body parts can fix them
Islamic history during medieval period
- hospitals invented in Islamic civilization (Baghdad)
- Avicenna wrote the Canon of Medicine about use of anesthesia! (sponge soaked with opium, mandrake, or henbane)
general aspects of traditional medicine
- healing is about the mind, body, and external environment
- plant/animal medicinals heal by restoring balance
- body is a conduit of energy
main difference in traditional vs allopathic medicine
- traditional medicine is belief-based
- allopathic (modern) medicine is evidence-based!
Paracelsus
- lived during Renaissance (lots of intellectualism, scientific inquiry, anatomic art)
- was an iconoclast and rejected doctrine of signatures and Greek medicine
- believed in alchemy (plant extracts)
- developed idea of toxicology
traditional Indian medicine
- ayurveda: system of plant medicinals
- few animal parts compared to traditional Chinese
- first medication for schizophrenia (snakeroot)
traditional Chinese medicine text + beliefs
- Pen Tsao: texts with medicinal plants (including chaulmoogra), attributed to Shen Nung??
- believed body was conduit of energy (chi); meridians in the body
history of medicine in Europe post-renaissance (Enlightenment)
- dispensatorium (early pharmacopia by Valerius Cordus)
- Herball: English book about many plant species, by John Gerald
- Carl Linnaeus: wrote wrote Species Plantarus; binomial classification of plants (naming system)
history of medicine in North America
- Asa Gray: identified plant species and helped Darwin with botanical aspects of natural selection; believed there was genetic connection between all species
- shakers: traded medicinal plants in NH with Native Americans
- heroin invented during civil war to replace morpheine
vitalism
- belief that living things were distinctly different from non-living things
- disproven with inorganic synthesis of urea
- Pasteur and Koch invented vaccines, further disproving
Misama vs Germ theory
- Misama theory: diseases came from polluted air (Galen)
- Germ theory: diseases came from microorganisms
foxglove
- used in indigenous medicine to treat swelling
- scientific basis: foxglove tea is an antiarythmatic agent that helps CHF and thus treats dropsy (edema)
- contains cardiac glycosides digitalin and digoxin–different onset time so must be careful with dosage!!
common chemical compounds in medicinals
- fatty acids and oils: purgatives, emulsifiers, antiseptics
- glycosides: sugars bound to another fxl group
- alkaloids: cyclic compounds with N
glycosides
- sugars bound to fxl group
- can be medicine or poison depending on dosage
- example: caterpillars ingest glycosides from milkweed which become part of monarch wings (anti-predatory)
alkaloids
- cyclic organic compounds with N
- can be addictive (opium, nightshade, hemlock)
- poisonous depending on dosage–standardization of dosage is important!
use of chaulmoogra for leprosy
- Hansen’s disease (leprosy) is caused by Mycobacterium leprae; causes sores and PNS damage
- lepers historically isolated in colonies
- chaulmoogra seed oil applied topically to sores in ayurvedic medicine and TCM
- Joseph Rock from Univ. of Hawai’i went to India to obtain chaulmoogra to bring back to leper colonies (bioprospecting)
- chaulmoogra replaced by dapsone in 1920s
bioprospecting and biopiracy
- bioprospecting: exploration to new areas to obtain medicinal plants
- biopiracy: bioprospecting when knowledge of medicinals or plants themselves are taken without consent
use of quinine for malaria
- natives in Brazil used Cinchona bark to prevent + treat malaria (contained quinine)
- when Portuguese governor’s wife got malaria, a shaman was starved to get information on treatment (biopiracy)
- turned into tonic by colonizers–now tonic water today!
conducting ethical ethnobotanical surveys
- interviewing shamans can infringe on intellectual property rights (their medicinal cures should be kept private)
- better to go to markets with medicinal plants which are accessible to everyone!
- look for triangulation for strongest evidence of medicinals (multiple cultural groups that use it)
alternative medicine in the US
- lifestyle industry–people want to be healthy and fit
- Complimentary and Alternative Medicine (CAM): includes herbalism, aromatherapy, accupuncture, massage, etc (mixture of many different worldwide cultural healing systems)
Dietary Supplement Health and Education Act
states that branding of herbal/botanical/dietary supplements can’t guarantee any cures
positive and negative motivations for trying CAM
negative:
- poor doctor-patient relationship
- insufficient time with doctor
- “high tech low touch”
- no effective allopathic treatment
- rejection of technology
positive:
- better relationship with provider
- more in control of treatment
- “high touch low tech”
- more accessible
- less invasive
- pleasant experience
using St. John’s wort vs prozac
both can treat depression!
- St. John’s wort has several active compounds with different effects and onset time that must be considered!
- prozac has one active compound that’s more concentrated; easier to dose
common herbals for digestive system
- ipecac: emetic
- triphala: laxative
- pedia-calm: treats acidity and gas
- gasex: treats gas and cramping
other common herbal supplements
- bitter melon; gymnema: drop blood sugar
- valerian root: helps anxiety
preparation of herbal medicines
- often have to be dry to make medicines (require <10% moisture)
- some dry in sunlight, others hung
system of care in Arabic medicine
- physicians diagnosed, pharmacologists gave prescriptions and had medicinal knowledge