Exam 3 Flashcards

1
Q

what are vitamins?

A

organic compounds that are required in small quantities for specific functions, such as the maintenance of regulatory and metabolic processes in the body.

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2
Q

what are organic compounds?

A

compounds that contain both carbon-carbon and carbon-hydrogen bonds.

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3
Q

why is it necessary for human to obtain vitamins through diet?

A

in most cases, human cells cannot synthesize vitamins; but in the few vitamins manufactured by the body (or by intestinal bacteria) are not produced in amounts sufficient to meets our needs

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4
Q

are vitamins an energy source?

A

no, but we need a number of them in order to extract energy from macronutrients as well as provide many regulatory and metabolic functions in the body and proper cell functioning, development, and growth.

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5
Q

what is bioavailability?

A

the degree to which nutrients can be absorbed and utilized by the body.

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6
Q

what can influence bioavailability, particularly for vitamins?

A

physiological and dietary condition; the presence of disease, chronic alcohol abuse, and age-related physiological changes can decrease bioavailability; it can also be affected by the presence of other nutrients or food components hat can enhance or reduce absorption or by food-handling practices such as whether you cook a food or eat it raw.

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7
Q

how are vitamins grouped?

A

according to their solubility: fat-soluble vitamins and water-soluble vitamins.

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8
Q

what is solubility?

A

the ability of a substance to dissolve in a solution.

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9
Q

what are fat-soluble vitamins?

A

require the presence of bile acids for absorption, and are stored in body tissue; vitamins A, D, E, and K.

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10
Q

what are water-soluble vitamins?

A

vitamins that disperse easily in water-based solutions; B vitamins, vitamin , and the vitamin-like nutrient choline.

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11
Q

what is the plant form of vitamin A?

A

betacarotene.

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12
Q

what are possible benefits of betacarotene?

A

provide benefits through their ability to function as antioxidants in the body.

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13
Q

what are antioxidants?

A

a substance that prevents damage to cells by inhibiting the oxidation caused by free radicals.

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14
Q

what are free radicals?

A

molecules that are naturally formed in the body or are present in the environment that have an unpaired electron; at high levels they damage cells, including DNA, through a process called oxidation.

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15
Q

what is oxidation?

A

a loss of electrons; in the bod, this results in damage to cells.

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16
Q

what are some results of oxidation in the body?

A

it can alter DNA, destabilize cell membranes, lead to chronic diseases such as cancer and heart disease.

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17
Q

what are some benefits of ample dietary intakes of carotenoids?

A

can provide some protection to the skin from the damaging effects of UV radiation from sunlight.

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18
Q

what is the vitamin A deficiency called?

A

hypovitaminosis A.

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19
Q

where is hypovitaminosis A most common/uncommon.

A

uncommon in the United States, common in developing countries due to a lack of access to preformed vitamin A and beta-carotene.

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20
Q

what are the effects of hypovitaminosis A?

A

mainly affect the eye, night blindness occurs due to problems in the synthesis of rhodopsin, decreased production of mucus in tears, which results in the cornea of the eye drying. if the deficiency continues, the affected cornea can become ulcerated and essentially melt away, causing scarring and permanent blindness; hypovitaminosis A is the leading cause of blindness in children worldwide; cornea ulcerations generally develop suddenly, occurring mostly in children aged 1-4 and typically causing blindness. this deficiency causes a high risk of death due to impaired immunity and an increased likelihood of infections; other symptoms include rough, dry, or scaly skin resulting from a loss of moisture in the mucous membranes; keratinization occurs in the epithelial cells that cover the surface of our bodies and line body cavities, epithelial cells cannot develop properly and they become filled with a fibrous structural protein called keratin.

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21
Q

what is vitamin A toxicity called?

A

hypervitaminosis A.

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22
Q

what is the UL for vitamin A?

A

3000 mcg.

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23
Q

what are the effects of hypervitaminosis A?

A

defects or weaknesses in bones, leading to osteoporosis or fractures; in pregnant women, intake of vitamin A above the UL can interfere with fetal development, increasing the risk of birth defects, excess provitamin A as beta-carotene from plant sources has not been demonstrated to cause toxicity but may only temporarily turn skin yellow or orange.

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24
Q

what are characteristics of fat soluble vitamins?

A

small amounts necessary for good health, absorption occurs in the small intestine, leave the small intestine in chylomicrons, often present in fatty portion of foods, stored in tissue; toxicity possible when consumed in excess, dissolves in lipid.

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25
Q

what are characteristics of water soluble vitamins?

A

small amounts necessary for good health, all except choline function as coenzymes, most circulate freely in blood, many are easily destroyed or removed during food storage or preparation, not stored in large amounts in tissues; toxicity generally does not occur, dissolve in water.

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26
Q

what are possible causes of vitamin deficiencies?

A

inadequate intake, decreased absorption, decreased utilization in cells, increased requirements, increased breakdown, and increased losses and excretion.

27
Q

what are examples of inadequate intake?

A

calorie restriction, poverty, anorexia, food fads, difficulty swallowing, dental problems, decreased taste and smell, illness.

28
Q

what are examples of decreased absorption?

A

poor digestion, diarrhea, parasites, intestinal disorders, dietary anti vitamin factors, GI infections, prescription drugs, alcohol.

29
Q

what are example of decreased utilization in cells?

A

deficiencies in other nutrients, prescription drugs, alcohol, or infections

30
Q

what are examples of increased requirements?

A

growth, pregnancy, location, chronic illness, infections

31
Q

what are examples of increased breakdown?

A

prescription drugs, alcohol

32
Q

what are examples of increased losses and excretion?

A

increased urinary excretion, blood losses (gastric ulcers), parasites, infection

33
Q

what is rhodopsin?

A

a visual pigment made of retinal and the protein opsin.

34
Q

what happens what light strikes rhodopsin?

A

retinal changes its shape from cis to trans and then a nerve impulse sends the visual signal to the brain and retinal is released from rhodopsin to form opsin.

35
Q

what does a vitamin A deficiency do in regards to retinal and rhodopsin?

A

decreases the availability of cis-retinal, delaying the reformation of rhodopsin, and night vision is slow to recover after exposure to a bright light.

36
Q

what is retinol?

A

preformed vitamin A; more readily absorbed, animal foods and fortified foods; beta-carotene gets converted to retinol.

37
Q

what are dietary sources of vitamin A?

A

animal products - liver, fish liver oil, milk, milk products, butter, eggs (when milk is skimmed, vitamin A is lost)
plant products - deep yellow, orange plants (carrots, sweet potatoes), dark leafy greens (spinach).

38
Q

what are functions of vitamin D?

A

acts as a hormone, helps bone growth and maintenance, regulate calcium metabolism (blood levels, absorption, excretion), regulates the synthesis of certain proteins, possibly regulates cardiovascular function.

39
Q

how does vitamin D function as a hormone?

A

calcitriol increases absorption of calcium in the intestine, active vitamin D and parathyroid hormone decrease calcium excretion by the kidneys.

40
Q

what is the role of vitamin D in bone growth?

A

assists with the absorption of calcium and phosphorus, maintaining blood concentrations (increased absorption GI tract, resorption in kidneys, mobilization in the bones), bones grow denser and stronger as they absorb these minerals.

41
Q

what must happen before vitamin D can function in the body?

A

it must be activated in the kidneys and liver

42
Q

what may vitamin D deficiency increase the risk of?

A

rickets (in children), osteomalacia (in adults), cancer, autoimmune disease, kidney disease, type 2 diabetes, cardiovascular disease.

43
Q

what are sources of vitamin D?

A

fortified milk, egg yolks, fatty fish (salmon, mackerel, sardines), fortified soy milk, fortified cereals, 10-20 minutes sun exposure.

44
Q

what are the effects of vitamin D toxicity?

A

raises blood concentration of calcium, calcium precipitates in soft tissues, stones form, especially in kidneys, may harden blood vessels, major arteries, can lead to death

45
Q

what are the functions of vitamin E?

A

incorporated into the cell membrane (antioxidant protecting against oxidative damage), healthy immune function; neutralizes free radicals and breaks the chain of oxidative damage.

46
Q

what are some sources of free radicals?

A

mitochondrial energy metabolism, cigarette smoking, air pollution, UV light, some drugs, immune responses.

47
Q

what can free radicals affect?

A

DNA, protein, lipids, LDL.

48
Q

what characterizes vitamin E deficiency?

A

primary deficiency is rare, but secondary deficiency related to fat malabsorption is seen with steatorrhea, i.e. cystic fibrosis; red blood cells break and spill contents, probably related to oxidation of PUFA in membranes; erythrocyte Hemolysis; Hemolytic Anemia.

49
Q

what are some sources of vitamin E?

A

vegetable oils, products made from vegetable oils, wheat germ oil, almonds, egg yolks, dark leafy greens

50
Q

why is vitamin K injected into newborn?

A

to rescue the risk of hemorrhaging.

51
Q

what is the function of vitamin K?

A

needed for synthesis of protein for blood clotting and bone metabolism (modifies bone proteins - regulates bone formation and to allow calcium to bind to bone.

52
Q

what are some sources of vitamin K?

A

green vegetables, cabbage, vegetable oils, milk.

53
Q

what characterizes a vitamin K deficiency?

A

uncontrolled bleeding; primary deficiency is rare, secondary deficiency - fat malabsorption, drug interaction (disrupt vitamin K synthesis and action, antibiotics kill vitamin K producing bacteria in the GI tract.

54
Q

what is characteristic of most B vitamins?

A

most are coenzymes in energy metabolism.

55
Q

what are food sources for thiamin?

A

pork, fortified and enriched cereal products, seeds and some nuts, fish.

56
Q

what characterizes thiamin deficiency?

A

beriberi - mental disturbances, muscle weakness, impaired cardiac function; wernicke-korsakoff syndrome - can result in severe neurological disturbances, up to 80% of chronic alcohol abusers show signs of deficiency.

57
Q

what is the function of thiamin (B1)?

A

assists in energy metabolism, special site on nerve cell membranes needed for the production of neurotransmitters, required for DNA/RNA synthesis, vitamin portion of the coenzyme TPP (thiamin pyrophosphate).

58
Q

what is the function of riboflavin (B2)?

A

coenzyme in many reactions.

59
Q

what are characteristics of riboflavin deficiency?

A

Ariboflavinosis - cracks and redness of the lips and corners of the mouth, swelling of the mouth and sore throat; rare by itself, typically with other B-vitamin deficiencies.

60
Q

what are some sources of riboflavin?

A

milk, milk products, dark leafy greens, nutritional yeast
UV light and irradiation destroy riboflavin, heat stable.

61
Q

what is the function of niacin (B3)?

A

metabolic activity - essential in energy transfer reactions, metabolism of glucose, fat, alcohol; synthesis of glucose, fatty acids, cholesterol, and steroid hormones; DNA repair/gene expression; cell signaling - protects against neurological degradation; unique in that it can be made form the amino acid tryptophan.

62
Q

what are some sources of niacin?

A

poultry, fish, meat, fortified cereals, peanuts, mushrooms

63
Q

what characterizes niacin deficiency?

A

pellagra - fatigue, scaly skin, mouth sores, diarrhea, confusion, and ultimately mental deterioration

64
Q

what characterizes niacin toxicity?

A

raise blood concentrations to abnormally high levels - ‘niacin flush’ - dilates capillaries, painful tingling sensation; 3-4x RDA