Exam 2 Worksheets Flashcards
What are the primary functions of the respiratory system? You should be able to name 4-5 functions
- Exchange of gases between the atmosphere and the blood
- Helps regulate of body pH
- Protection from inhaled pathogens and irritating substances (dust, pollen, pollutants, bacteria etc)
- Vocalization or production of speech
- Sense of smell
Provide an overview of the 4 processes required for exchange of gases between the atmosphere and the blood. Be sure to include relevant terminology.
There are four important events that need to happen in order for gases to pass from the atmosphere and the blood. These events include – pulmonary ventilation, external respiration, transport of respiratory gases, and internal respiration. Pulmonary ventilation is the processes of breathing, or the cycling between inspiration (bringing air into the lungs) and expiration (moving air out of the lungs). External respiration happens in the alveoli where oxygen diffuses from the alveoli (air spaces) into the blood in the pulmonary capillaries and carbon dioxide diffuses from the blood into the alveoli. Transport of blood is the movement of blood from the lungs to reach the tissues and movement of blood from the tissues back to the lungs. During this transport, the blood moves through both the systemic and pulmonary circuits of the cardiovascular system (and the heart). Internal respiration is the process of gas exchange between the blood and the body’s cells – oxygen leaves the blood and enters the cells while carbon dioxide leaves the cells and enters the blood.
How do the anatomical features of the respiratory system allow humans to live in dry climates?
One of the principal actions of the conducting passageways that make up the respiratory system is to warm, humidify, and filter the air. This action is facilitated by superficial blood vessels that allow for heat exchange, seromucous gland secretions that create a humid environment, and the mucociliary escalator that allow trapped pathogens to be trafficked to the digestive system for destruction. These anatomical features of the respiratory system allow us to live in many different climates because no matter what the surrounding atmosphere looks like, when the air enters the alveoli it is warm, humid, and clean.
Explain what is meant by mucosa or mucous membrane.
A mucosa, or mucous membrane is the name of the lining of all body cavities that open to the outside of the body – such as the hollow organs of the respiratory, digestive and urogenital tracts. These linings are wet or moist and consist of the epithelium that lines the lumen or cavity of the organ, and the connective tissue layer, or lamina propria just deep to the epithelium.
Describe the respiratory mucosa and list where it can be found.
The respiratory mucosa lines most of the upper respiratory tract (nasal cavity, paranasal sinuses, nasopharynx) and some of the lower respiratory tract (larynx below the vocal cords, trachea, upper parts of bronchial tree). The respiratory mucosa is responsible for conditioning the air that comes into the respiratory system through the nasal cavity. The respiratory mucosa consists of ciliated pseudostratified columnar epithelium with goblet cells and a lamina propria that contains seromucous glands and a rich network of blood capillaries. Seromucous secretions include a watery solution, and a sticky mucous; these secretions pass through ducts to reach the lumen surface. Mucous secretions on the surface of the epithelium capture inhaled particles and the gently beating cilia sweep the mucous and trapped particles toward the pharynx for swallowing. Watery secretions from seromucous glands help to humidify the air, Blood vessels in the lamina propria warm incoming air, and help to recapture heat in outgoing air.
Describe the gross anatomy of the nasal cavity. How do these structures facilitate the primary functions of the respiratory system?
The most interesting feature of the nasal cavity is the nasal conchae, which rise like scrolls from the lateral walls. The nasal conchae are made of bone, and they are covered by respiratory mucosa. There are spaces called nasal meatuses between the 3 conchae (superior, middle, and inferior). The conchae increase the surface area of the cavity and create turbulent wind tunnels, maximizing contact of the air with the mucosa lining. This movement of the air ensures efficient conditioning of the air entering the nasal cavity and facilitates the removal of particles from the air.
The nasal cavity contains two different types of mucosa. The
olfactory mucosa and the respiratory mucosa. The olfactory mucosa lines the superior part of the nasal cavity and contains the olfactory neurons that form cranial nerve I and
convey the sense of smell. The respiratory mucosa is a pseudostratified ciliated columnar epithelium with Goblet cells. The cilia beat the mucous toward the back of the throat and toward the digestive system. Seromucous glands produce mucus and enzymes that help trap and kill pathogens found in the air. Blood capillaries in the lamina propria help warm incoming air and reclaim heat in outgoing air.
What are paranasal sinuses? Where are they found? What do they do?
The paranasal sinuses are air filled spaces in some of the skull bones that surround the nasal cavity. Sinuses form a ring around the nasal cavity and are found in the frontal bone, sphenoid bone, ethmoid bone and maxillary bones. The sinuses are named according to the bone where they are located (i.e. frontal sinus). Sinuses are lined by respiratory mucosa, and they have holes that drain directly into the nasal cavity. Sinuses lighten the skull and may help to warm and humidify the air.
Describe the anatomy of the pharynx. Be sure to compare and contrast the different regions.
The pharynx is muscular tube that serves as a conduit between the nasal, oral cavity and the lower respiratory system. It is the anatomical region commonly known as “the throat.” There are three regions that make up the pharynx – the nasopharynx, the oropharynx, and the laryngopharynx. The nasopharynx is the most superior region and is posterior to the nasal cavity. This region only allows for the movement of air and so has a pseudostratified ciliated epithelium (respiratory mucosa). The oropharynx is posterior to the oral cavity and therefore allows for the passage of both air and food, so we observe a stratified squamous epithelium here. The laryngopharynx is the more inferior region and is posterior to the larynx. The laryngopharynx is where food is directed into the digestive system (esophagus) and air into the respiratory system (larynx). Because food (as well as air) passes through the laryngopharynx, the epithelium is stratified squamous.
Describe the anatomy and primary functions of the larynx, including the vocal ligaments.
The larynx is a composed of a series of cartilages connected by membranes and ligaments. The most prominent cartilage is the thyroid cartilage that can be found on the anterior side of the larynx. The epiglottis is the only elastic cartilage in the larynx; movement of foodstuffs into the pharynx moves the epiglottis over the opening into the larynx, inhibiting the movement of food into the lower respiratory system. The larynx performs three functions – providing a patent airway, inhibiting the entry of food into the lower respiratory system, and voice production. The open space that allows the movement of air between the upper and lower respiratory system is the glottis. Crossing the glottis are two ligaments called the vocal cords (vocal folds). Muscles that draw the
vocal cords together narrows the glottis; muscles that tense the vocal cords raise the pitch of sound produced by air moving through the glottis.
What is the mucociliary escalator? Where is it found? Why is it important for respiratory system function?
The mucociliary escalator is created by the respiratory mucosa, and can be found in any structures lined by respiratory mucosa, such as the nasal cavity, nasopharynx, lower larynx, trachea and upper regions of the bronchial tree. Secretions from the seromucous glands and goblet cells create two layers of fluid that cover the apical surface of the pseudostratified epithelial cells. A deep watery layer allows the cilia to move freely. The superficial mucus layer traps and inhaled particles or pathogens. The constant beating of the cilia moves the mucus and any trapped particles toward the pharynx where they will be swallowed and directed into the esophagus (digestive system). The mucociliary escalator cleans inhaled air and helps ensure that no foreign particles reach the lower delicate parts of the respiratory system (alveoli).
Which of the following is NOT a benefit of breathing through the nose?
Absorption of oxygen into the blood
Where is the olfactory mucosa?
On the upper border of the superior nasal concha
Which of these structures is lined by stratified squamous epithelium instead of the typical respiratory epithelium?
Oropharynx
hich word or phrase describes the movement of air between the atmosphere and the lungs?
Ventilation
High pitched sounds are generated by air movement over _________.
High tension vocal folds
Describe the anatomy of the lungs.
There are two lungs within the thoracic cavity. The lungs are surrounded by the thoracic cage which is formed by the ribs, sternum, and vertebral column posteriorly. The lungs are located on either side of the mediastinum and fill the space between the rib cage, the diaphragm, and the lateral surface of the pericardium. The left lung contains two lobes, a superior lobe and an inferior lobe separated by the left oblique fissure. The right lung contains three lobes, a superior, middle, and inferior lobe. The right superior and right middle lobe are separated be the horizontal fissure, while the right oblique fissure separates the right middle and right inferior lobes. Each lung is served by a primary or main bronchus that enters at the hilum. The hilum is the area on the medial surface of the lung where the blood vessels, bronchi, nerves and lymphatics enter and leave the lungs.
The lungs are surround by the pleurae or pleural sacs which are described below.
Describe the anatomy of the bronchial tree including structural changes that occur in the various branches.
The trachea branches into two primary or main bronchi which enter each lung on their medial surface. The primary bronchus quickly branches into secondary or lobar bronchi that serve each lobe (2 on the left and 3 on the right). Secondary bronchi branch into tertiary or segmental bronchi. Bronchi continue dividing into smaller divisions. Larger bronchi are lined by the typical respiratory mucosa – ciliated pseudostratified columnar epithelium with goblet cells with a lamina propria, which is responsible for conditioning the air entering the lungs. The bronchi also have hyaline cartilage plates in their walls for structural support. The larger bronchi have more cartilage, and the cartilage plates start to get smaller and are replaced by smooth muscle cells in smaller bronchi. Once the cartilage plates disappear, the branching air passageways are called bronchioles. Bronchioles are about 0.5 – 1 mm in diameter, have no cartilage in their walls, but do have smooth muscle cells. There is also a change in the epithelium as the passageways get narrower. The epithelium transitions from a pseudostratified columnar to a cuboidal cell type with fewer mucus secreting cells and cilia. Smooth muscle in the walls of the bronchioles
help control air flow by constricting (bronchoconstriction) or dilating (bronchodilation) the lumen of the bronchiole
What is the functional difference between the conducting and respiratory zone? What is the anatomical feature that delineates the transition from conducting to respiratory zone?
The conducting zone structures primarily are responsible for moving air from the atmosphere toward the respiratory zone. Along the way the air is humidified, warmed, and cleaned (filtered). The respiratory zone is where gas exchange occurs. The respiratory zone is defined by the presence of the alveoli. So, the presence of the first alveolus marks the transition from conducting to respiratory zone.
Describe the anatomical features of the respiratory zone.
The respiratory zone contains respiratory bronchioles, alveolar ducts, alveolar sacs, and individual alveoli. By definition, the respiratory zone is where the alveoli are located because this is where gas exchange can occur.
The respiratory bronchiole is the smallest type of bronchiole and it is the first part of the bronchial tree where we start to see alveoli – it’s actually the last part of the bronchial tree too, because bronchioles will transition into alveolar ducts. Bronchioles are considered respiratory bronchioles if they have alveoli in their walls. Respiratory bronchioles transition into alveolar ducts, which are long hallways lined by alveoli. Alveolar sacs are clusters of alveoli at the ends of alveolar ducts. The alveolar sacs are analogous to a cluster of grapes, while an individual alveolus is analogues to a single grape. The alveoli are surrounded by elastic fibers which impart elasticity to the air spaces – the elastic fibers allow them to inflate easily when they fill with air, and they recoil to their original shape during exhalation. The alveoli are also surrounded by pulmonary capillaries which carry blood that needs to be oxygenated.
List the cell types that are found in the alveoli, and describe their functions.
Type I alveolar cell – flat squamous cells that form most of the wall of the alveolus. It forms part of the respiratory membrane across which gas exchange occurs.
Type II alveolar cell – cuboidal shaped cell that secretes surfactant which coats the inner surface of the alveoli and decreases surface tension.
Alveolar macrophage – these cells are phagocytes that keep the respiratory zone of the lung free from debris. They clean up and dust or pieces of dead cells that end up in the alveoli. Some textbooks call them “dust cells”
What is the respiratory membrane and how is it formed? Where do we observe this membrane?
The respiratory membrane is formed by the very thin wall of the alveolus and wall of the capillary across which respiratory gases cross. The respiratory membrane is typically about 0.5 um and is formed by a squamous Type I alveolar cell, the endothelial cell of the pulmonary capillary and the fused basement membranes (or basal lamina) between these two cells. This ultra-thin membrane allows for diffusion of gases between the alveolar air space and the blood. The respiratory membrane is found in the respiratory zone structures in between the walls of the alveoli and the pulmonary capillaries that surround the alveoli.
Describe the relationship between the pleurae and the lungs.
Each lung is surrounded by a double layered serous membrane sac called the pleurae or pleural sac. The pleural sac is like a balloon, and the lungs are like a fist that is pushed into the balloon. The layer of the pleural sac (balloon) that covers the surface of the lung including the fissures separating each lobe is called the visceral pleura. The layer of pleura that lines the inner surface of the thoracic wall, the superior face of the diaphragm, and the lateral wall of the mediastinum is the parietal pleura. The visceral and parietal pleura are continuous with each other at the hilum, the indentation on the medial surface of the lung where bronchi and blood vessels enter and leave the lung. In between the parietal and visceral pleurae is the pleural cavity that contains a small amount of pleural fluid. In addition to creating a slippery surface that allows the pleural layers to move freely during breathing, the surface tension created by this fluid makes the visceral and parietal pleural layers cling closely to each other (like the walls of a wet plastic bag) which is important in the mechanics of breathing (pulmonary ventilation)
Two separate sets of arteries bring blood to the lungs. Name these two arteries and compare and contrast their functions.
The pulmonary arteries (branches of the pulmonary trunk leaving the right ventricle) carry deoxygenated blood to the lungs to pick up fresh oxygen in the pulmonary capillary beds. These pulmonary arteries are part of the pulmonary circuit that brings low pressure, low oxygen blood to the lungs. This circuit is also high volume, because all of the body’s blood has to come to the lungs for re-oxygenating. Because of this, enzymes that need to work on material in the blood can be located in the lungs.
The bronchial arteries are branches of the aorta, and bring freshly oxygenated blood to the lung to supply oxygen to lung tissue cells to use for cellular respiration. The bronchial arteries are part of the systemic circulation which carries oxygenated, high pressure blood to tissues in the body.
What is a bronchopulmonary segment and why is it clinically relevant?
Each lobe of the lung contains a number of pyramid shaped bronchopulmonary segments that are separated from each other by connective tissue septa. These segments correspond to the regions of the lung that are served by tertiary (or segmental bronchi). In addition to receiving air from its own bronchus, each bronchopulmonary segment is served by its own artery and vein. This is important clinically because pulmonary disease is often limited to one or two segments of the lungs. Physicians typically move the stethoscope around when listening to breathing in order to detect abnormal sounds in any of the individual segments of the lung,