Exam 1 (WRKSHTS) Flashcards
define ganglion
collection of neuron cell bodies outside the CNS
define preganglionic neuron
the first neuron of the 2 neuron autonomic chain; cell body is in the CNS, axon extends into periphery and synapses in autonomic ganglion
define postganglionic neuron
the second neuron of the 2-neuron autonomic chain; cell body is in the autonomic ganglion, axon extends to target cell (smooth muscle, cardiac muscle, or gland cell)
define viscra
organs
define plexus
a network of nerves; for the ANS, contains both sympathetic and parasympathetic nerves
Name the three main cell types in the body innervated by the autonomic nervous system
Smooth muscle, cardiac muscle, glands
Relative to the autonomic nervous system, what do we mean when we say that an organ receives “dual innervation”
Dual innervation means the organ receives both sympathetic and parasympathetic postganglionic axons. Usually sympathetic activation will drive organ function in one direction, and parasympathetic activation in the opposite direction. Organ function at any one time is a balance between sympathetic and parasympathetic release
what happens when an action potential travels down the axon to the terminal
The action potential causes calcium entry into the terminal, which allows vesicles to bind to terminal membrane and release neurotransmitter into the space between the terminal and the target cell; transmitter diffuses to target cell
What happens when neurotransmitter reaches the target cell membrane
Target cell has receptors on its membrane which bind the transmitter. Binding stimulates events in the target cell, which vary depending on the type of target cell : muscles cells can contract or relax, gland cells can secrete, etc
You are given a drug that binds to receptors on the target cell and has the same effect as the neurotransmitter. What would happen to the target cell?
Since the drug has the same effect as the transmitter, the target cell would respond in the same way as if it had bound transmitter
Does the neuron need to fire an action potential to see the effect of a drug that binds to receptors on the target cell
If a drug is binding directly to the target cell, the neuron does NOT need to fire an action potential and release transmitter in order for the target cell to respond. The drug binding to the receptor triggers events in the cell directly.
You are given a different drug that binds to and blocks all the receptors on the target cell, meaning that the drug does not affect the cell but occupies all the receptors so that neurotransmitter cannot bind to the target cell. What would happen to the target cell when you applied the drug?
There would be no effect on the target cell. The drug simply binds to the receptors, but does not stimulate the cell in any way
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the parasympathetic ganglion cell body
nicotinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the sympathetic ganglion cell body
nicotinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the smooth muscle cell that contracts when stimulated by norepinephrine
alpha 1 adrenergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the smooth muscle cell that relaxes when stimulated by norepinephrine
beta 2 adrenergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the postganglionic sympathetic nerve terminal
alpha 2 adrenergic (the autoreceptor for feedback)
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the smooth muscle cell that responds to acetylcholine
muscarinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the salivary gland cell that responds to acetylcholine
muscarinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the sweat gland cell
muscarinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the cell in the adrenal medulla
nicotinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the target cell in the heart that slows the heart rate when stimulated by acetylcholine
muscarinic cholinergic
what kind of receptor (alpha 1, alpha 2, beta 1, beta 2, nicotinic, muscarinic) would you find at the target cell in the heart ventricle that contracts harder when stimulated by norepinephrine
Beta 1 adrenergic
You are out hiking in the remote woods when a small landslide traps your friends under the trunk of a collapsed tree. You race to their aid and miraculously lift the limb and help them to safety. How were you able to summon this hidden power?
Such an event triggers the “fight or flight” reaction, and gives an adrenaline rush – release of epinephrine (the same hormone that used to be called adrenaline) into the blood stream, and, in addition, activation of sympathetic neurons everywhere in the body