Exam 2 subdeck

Question 1

Tetanus and Botox

Answer 1

proteases that cleave SNARE proteins

Question 2

nAChR

Answer 2

• cys-loop
  
  • pentamers
  • each subunit has 4 transmembrane helices
  • a2ByE
  • must bind 2 ACh to open

Question 3

muscarine

Answer 3

agonist in heart

Question 4

atropine

Answer 4

antagonist in heart

Question 5

nicotine

Answer 5

agonist in muscle

Question 6

curare

Answer 6

antagonist in muscle

Question 7

a-bungarotoxin

Answer 7

antagonist in muscle

Question 8

• Glutamate receptors:

Answer 8

• tetramers
  
  • each subunit has 3 transmembrane helices
  • LBD: agonist
  • ATD: modulators

Question 9

GABA(A) receptors

Answer 9

• cys-loop
  
  • Cl selective
  • each subunit has 4 transmembrane helices
  • Bicuculline: competitive antagonist
  • Picrotoxin: non-comptentitive antagonist
  • Barbituates, Diazepam, Ethanol: positive modulators
  • NKCC1 young (high intra Cl), KCC2 adult (low intra Cl)