Exam 2 Questions

Question 1

What effect does lipocortin (lipomodulin) have?

Answer 1

inhibits inflammatory pathway by blocking PLA2, enzyme inhibitor

Question 2

How do steroids reduce inflammation?

Answer 2

leads to production of lipocortin which inhibits PLA2

Question 3

What two end products of the arachidonate pathway have antagonistic effects?

Answer 3

PGI2 (clot prevention) and TXA2 (aggregation)

Question 4

Where do the substrates of the arachidonate pathway come from?

Answer 4

phospholipid bilayer

Question 5

A dose of 650 mg of ASA would be effective for what?

Answer 5

anti-inflammation

Question 6

Which has a higher bioavailability, LMWH or Heparin?

Answer 6

LMWH

Question 7

Which class of drugs is know for causing pruritus and flushing?

Answer 7

Opioids (Hydrocodone & Tramadol)

Question 8

Which mediator is reduced by steroids that induces fever?

Answer 8

prostaglandins

Question 9

Which drug is a leukotriene inhibitor?

Answer 9

Montelukast

Question 10

Which drug is an anticholinergic?

Answer 10

Tramadol

Question 11

Which drug is a prophylactic for migraine therapy?

Answer 11

Tropiramate

Question 12

What effect doe beta blockers have with Advair Diskus due to the presence of Salmeterol?

Answer 12

antagonistic

Question 13

Which drug mechanism is to break disulfide bonds?

Answer 13

Acetylcysteine

Question 14

Cyanosis is a side effect of which drug?

Answer 14

Sildanafil

Question 15

Which drug creates methemoglobinemia when interacting with topical lidocaine?

Answer 15

Acetaminophen

Question 16

What drug do the effects of Salmeterol imitate?

Answer 16

Albuterol

Question 17

Which drug is contraindicated by a sulfonamide allergy?

Answer 17

Celecoxib

Question 18

What inflammatory mediators have antagonistic effects?

Answer 18

TXA2 and PGI2

Question 19

What inflammatory mediators cause fever reduction?

Answer 19

prostaglandins

Question 20

What inflammatory mediator is responsible for pain?

Answer 20

PGE2

Question 21

What drug is indicated for migraine therapy prophylaxis?

Answer 21

Topiramate

Question 22

What is the maximum dose that hydroxychloroquine can reach before causing renal toxicity?

Answer 22

1000 g

Question 23

What effects does ASA have that Acetaminophen does not?

Answer 23

anti-platelet & anti-inflammatory

Question 24

How does sildenafil affect blood?

Answer 24

affects the platelet phosphodiesterase

Question 25

What adverse effects are unique about Monteleukast?

Answer 25

flu-like symptoms and rash

Question 26

What class of drugs can cause pruitis and flushing?

Answer 26

opioids

Question 27

If a patient shows signs of a stroke, what drug might they be taking that could be causing the stroke?

Answer 27

Celecoxib

Question 28

If the patient has a hollenplast plaque (cholesterol), what drug did they take?

Answer 28

Warfarin | cholesterol embolism is an adverse effect

Question 29

What drug enhances antithrombin effects with the 3a receptor?

Answer 29

Enoxaparin

Question 30

What drug can cause a cataract?

Answer 30

Fluticasone

Question 31

What is the effect of increased levels of acetaminophen?

Answer 31

hepatotoxicity and nephrotoxicity

Question 32

What drug can cause nystagmus and diplopia?

Answer 32

Topiramate

Question 33

What drugs can cause glaucoma?

Answer 33

Fluticasone, Mometasone | Topiramate--> causes angle closure glaucoma

Question 34

What drug can cause viral infection and a nosebleed?

Answer 34

Mometasone

Question 35

What drug do you give to short episode asthmatics?

Answer 35

Beta-2 agonists

Question 36

What is the effect on cGMP by Sildenafil?

Answer 36

increase in cGMP

Question 37

Which drug is injected subcutaneously?

Answer 37

Enoxaparin

Question 38

What quality of Rivaroxaban makes it slightly advantageous over Enoxaparin?

Answer 38

oral dosing

Question 39

What drug was previously used as rat poisoning

Answer 39

Warfarin (Coumadin)

Question 40

Which drug had a lawsuit about excessive bleeding and does not have an antidote?

Answer 40

Rivaroxaban

Question 41

What is the most popular anti-coagulant taken orally?

Answer 41

Warfarin (Coumadin)

Question 42

What is a safe dosing of chloroquine?

Answer 42

200 mg

Question 43

What is the mechanism of Warfarin (Coumadin)?

Answer 43

inhibition of epoxide reductase, blocking the reduction of Vitamin K

Question 44

What clotting factor unites the extrinsic and intrinsic pathways?

Answer 44

Factor Xa

Question 45

What drug can cause serotonin syndrome?

Answer 45

Tramadol

Question 46

What drug would you not give someone with elevated intracranial pressure?

Answer 46

Vicodin (Hydrocodone)

Question 47

What is the life span of a platelet and how long would you expect the irreversible effects of Clopidogrel to last?

Answer 47

7-10 days

Question 48

How does ASA effect the bleeding time?

Answer 48

doubles

Question 49

What biogenic amine does Sumatriptan target and how does it effect it?

Answer 49

increases serotonin levels

Question 50

What is the most adequate therapy and first choice for persistent asthma?

Answer 50

steroids

Question 51

Which two drugs are prodrugs?

Answer 51

ASA and Clopidogrel

Question 52

What percent of patients that get Reye's syndrome due to ASA result in mortality?

Answer 52

35% mortality

Question 53

What symptoms are associated with Reye's syndrome?

Answer 53

liver degeneration, encephalopathy, GI disturbances

Question 54

Which NSAID is safe to take during pregnancy?

Answer 54

acetaminophen

Question 55

Which drug is indicated for acetaminophen overdose?

Answer 55

Acetylcystiene

Question 56

Which drug is indicated for opioid overdose?

Answer 56

Nalaxone

Question 57

Which drug is indicated for malaria treatment?

Answer 57

Hydroxychloroquine

Question 58

What is the mechanism of Adalimumab?

Answer 58

inhibits TNF-alpha

Question 59

What percentage of the respiratory drug actually makes it to the lungs when taken orally through an inhaler?

Answer 59

10%

Question 60

Which phosphodiesterase is involved in ocular phototransduction?

Answer 60

PDE6

Question 61

How many times less likely is Sildenafil to effect PDE3 than PDE5?

Answer 61

700 times less

Question 62

Which drug is an antibody analog?

Answer 62

Adalimumab

Question 63

Which drug causes Bull's eye maculopathy?

Answer 63

Hydroxychloroquine

Question 64

How does Sildenafil cause bleeding?

Answer 64

inhibit platelete phosphodiesterase

Question 65

Which drug mechanism is to accelerate the effect of antithrombin to inhibit Factor Xa?

Answer 65

Enoxaparin

Question 66

Which drug is weakly sympathomimetic?

Answer 66

Tramadol

Question 67

What should Abciximab be given in conjunction with?

Answer 67

ASA or heparin

Question 68

What drug is indicated to prevent cardiac ischemic complications?

Answer 68

Abciximab

Question 69

What is the mechanism of Abciximab?

Answer 69

bing to GP IIb/IIa receptor to inhibit platelet aggregation and bind to virtonectin receptor on vessel wall