Exam 2 Questions Flashcards
P53 is one of these, so is pRb
tumor suppressor
A normal cell growth and survival protein is likely a
proto-oncogene
This is the % recombinant offspring from a test cross
map units
This tends to cause one species to become two species
disruptive selection
A protein made then degraded as part of the cell cycle
cyclin
Multidrug resistant tuberculosis arises through
directional selection
Heredity of genes in human mitochondrial DNA shows
maternal inheritance
Programmed cell death or cell suicide
apoptosis
Genes used by females to construct their eggs can show
maternal effect
A mutation that is in normal body cells, not gametes
somatic
This phosphorylates pRb
CDK
Allele frequency change that tends to occur in small, isolated populations
genetic drift
A tetrad that has both parental and recombinant offspring types
tetratype
Small populations often lose genetic diversity because of this
genetic drift
Human babies average around 7 lbs due to ____ selection
stabilizing
Lee Hartwell, won the Nobel Prize for his work on cdc mutants. These mutants:
a. are conditional
b. include kinases
c. control the cell cycle
d. were isolated in yeast
e. all of the above
e. all of the above
If genes assort independently with one dominant and one recessive allele of each gene, a test crossed dihybrid with unlinked genes cross characteristically produces F1 progeny phenotypes in this ratio
a. 1:1
b. 1:2:1
c. 3:1
d. 9:3:3:1
e. 1:1:1:1
e. 1:1:1:1
Which of these is not where a cell cycle checkpoint occurs?
a. G1 to S
b. S to G2
c. G2 to M
d. M
e. all of the above have a major checkpoint
b. S to G2
Which of the following is not true of cancer genetics?
a. most mutations involved in cancer are somatic
b. it takes many mutations to change a normal cell to a cancer cell
c. one type of cancer has one set of mutations that causes it
d. cancer causing mutations include both gain of function and loss of function mutations
c. one type of cancer has one set of mutations that causes it
This is a trait common to all cancers
a. a mutator phenotype
b. gain of function mutations of proto-oncogenes to oncogenes
c. loss of function mutations in tumor suppressors
d. loss of checkpoint control
e. all of these
e. all of these
Which of these is not true about the pRB and hereditary retinoblastoma?
a. pRB is a tumor suppressor
b. retinoblastoma tissue has two defective copies of the pRB gene
c. hereditary retinoblastoma inherits as an autosomal recessive
d. pRB helps control the G1 to S transition
c. hereditary retinoblastoma inherits as an autosomal recessive
Mitochondrial diseases in humans typically involve
a. cancer
b. immune system problems
c. neuro-muscular problems
d. kidney and liver failure
c. neuro-muscular problems
Plants grown from seeds from a flower in a white sector of four o clock plant crossed with pollen from a green sector will be
a. mixed white and green
b. pale green
c. white and will die shortly after sprouting
d. green
c. white and will die shortly after sprouting
Which of the following is not true of mitochondrial DNA?
a. it is necessary for cellular respiration in eukaryotes
b. it appears to be the remnants of a bacterial genome
c. it follows basic Mendelian patterns of inheritance but is only seen in females
d. it can cause neuromuscular disease when mutant
c. it follows basic Mendelian patterns of inheritance but is only seen in females
