Exam 2 Pharm Maps Flashcards
Anticoagulants (Heparin) drug names (2)
Unfractionated heparin (Heparin)
Low Molecular Weight Heparin (LMWH) - enoxaparin (Lovenox)
Reason for taking Heparin
________ to prevent clot formation in pt. with the following conditions (5)
Prophylactically
1. MI (heart attack)
2. Atrial fibrillation
3. CVA
4. Post Stent
5. Implanted Devices
Action of heparin
Inhibits __ formation. Specifically, lla (thrombin)
Lovenox works more on ____
Clot
Factor Xa
Heparin contraindications (3)
Recent surgeries
GI bleed
PUD
Adverse reaction to heparin (3)
Heparin-induced thrombocytopenia (HIT)
Excessive bleeding
Bruising
Why is IV anticoagulant Heparin more dangerous?
Because bleeding can occur quickly
Assess ___ before & after administering Heparin
Bleeding
Assess low ___ (heparin)
Hemoglobin (anemia)
Assess ___ levels before administering each dose of heparin
PTT
___ levels bt. ___ & _____ is considered therapeutic (heparin)
PTT
bt. 46-70
Check med list for other ___ heparin
Anti-coagulants
HOLD lovenox if ___ are less than
platelets are less than 50 thousand
Report any ___ or ___ to the physician (Pt. education, heparin)
Unusual bleeding or bruising
(Pt. education) Pt. on heparin should wear a
Medical alert bracelet
(Pt. education) Rotate ___ with heparin
Injection sites
Avoid ___ with Heparin
Medication that causes bleeding (ex. NSAIDS)
(Pt. education) Heparin medication may ___
Burn or bruise
What is a unique aspect to heparin administration?
Keep the air bubble in the syringe
Antidote for heparin
Protamine Sulfate 1mg/100 units of heparin used
What site is heparin anticoagulants administered on a pt.
Love handles (only)
Signs of bleeding to watch for with heparin
Bleeding gums, blood in foley, IV site, any wounds, etc
Anticoagulant Vitamin K factor drug names (1)
Warfarin (Coumadin)
Reason for taking warfarin
Long term management of an MI, Afib, or any implantable devices
Action of warfarin
Inhibits production of vitamin K dependent clotting factors
Warfarin contraindications (4)
Recent surgeries
GI bleeds
PUD
Many drug interactions
Warfarin adverse reactions (3)
Bleeding
Purple Toe Syndrome
Warfarin Toxicity
Assess ____ before and after administering warfarin
Bleeding
Monitor ____ levels with warfarin (values)
PT/INR
1.0 normal
2 - 3.5 for therapeutic
Be ready to administer ___ if bleeding occurs with warfarin
Vitamin K 10 mg
For l____ t___ bleeding, administer (warfarin)
Life-threatening
Kcentra
(Pt. education, warfarin) Avoid ___
Alcohol
(Pt. education, warfarin) Report any ___ or ___ to physician
Unusual bleeding or bruising
Pt. who are on warfarin should wear a
Medical alert bracelet
(Pt. education, warfarin) Do not change intake amount of
Green leafy vegetables you eat
(Pt. education, warfarin) Avoid all ___
Herbal medication
What do you do if the warfarin level is toxic?
Stop medication, notify MD and prepare to administer vitamin K. Watch for bleeding
What are examples of foods to avoid with warfarin?
Green leafy vegetables
Spinach, Kale, Cabbage, Lettuce, but also Tomatoes
What 2 cardiac medications can decrease the effectiveness of warfarin?
Amiodarone & Diltiazem
What drug is often used with warfarin until warfarin reaches a therapeutic level?
Heparin IV
D/c after warfarin reaches therapeutic level
After receiving Vit. K, how long are pt.s resistant to warfarin?
Up to 7 days
The liver will begin to make more clotting factors once warfarin is stopped, but it can take up to ___ reach homeostasis. What is given to speed to process along?
3 or 4 days
Vit. K is given
Anticoagulants Factor Xa drug names (3)
Rivaroxaban (Xarelto)
Fondaparinux (Arixtra)
Apixaban (Eliquis)
Reasons for taking Factor Xa
Prevent CVA in patients with afib, post-op ortho surgeries, or Hx of DVT, PE - to help avoid a recurrence
Action of Factor Xa
Inhibits factor Xa production
Factor Xa contraindications (4)
Recent surgeries
GI bleeds
PUD
Avoid NSAIDS
Factor Xa adverse reactions (3)
Peripheral edema
Bleeding & bruising
Dizziness
Assess ___ before & after administering Factor Xa
Bleeding
What labs should be monitor with Factor Xa
- renal function (BUN & Create)
- Liver enzymes (ALT & AST)
(Pt. education, Factor Xa) Pt. should take ___ and be sure not to ___ or ___
Whole
Do not crush or split
(Pt. education, Factor Xa) If _ & __ occur, what should the pt. do?
Nausea & vomiting
Call MD immediately
(Pt. education, Factor Xa) Stop if ___ or ___
Unusual bleeding or bruising
(Pt. education, Factor Xa) Notify physician for ___
Black tarry stools
Why should you take caution with an epidural with Factor Xa? How long should you wait to start the medication?
Can cause a spinal hematoma once epidural is pulled
Start medication about 6 hours later
Antiplatelet drug names (2)
Aspirin (ASA)
Clopidogrel (Plavix)
Reason for taking antiplatelet
Post CVA, MI, & stent placements
Action of antiplatlets
Make platelets slicky so they don’t adhere to BV wall
Antiplatelet contraindications (4)
Many drugs
Amiodarone
PPI
CCB
NSAIDS
Antiplatelet Adverse reactions (5)
Bleeding
- Gums
- Nosebleeds
- Puncture sites
- Surgical sites
- Hematuria
What is hematuria?
Blood in urine
Monitor for ____ or ____ with Antiplatelets
Bleeding or bruising
(Antiplatelets nursing implications) Medication list for ___
Other NSAIDS, anticoagulants
Monitor ___ & ____ (Antiplatelet)
Platelets & hemoglobin (very little effect on these labs but if they are already low, could be an issue)
Take Antiplatelet at ____
The same time every day
Report any ___ or ___ to your physician (pt. education Antiplatelet)
Unusual bleeding or bruising
Do not crush ___ aspirin
Enteric-coated
Take aspirin with ___ or ___
6-8 ounces of water or with food
Caution with ____, ____, and ____ (Antiplatelet)
Ginko, ginger, & st. john’s wart
Why should you not skip an Antiplatelet dose?
Becomes less effective
What if pt. (who is on Antiplatelet) is taking aspirin for arthritis?
Make sure MD is aware/ Can increase risk of bleeding
Antihyperlipidemic bile acid sequestrants drug name
Cholestyramine (Questran)
Reason for taking antihyperlipidemic bile acid sequestrants
Hyperlipidemia (elevated lipids)
Action of antihyperlipidemic bile acid sequestrants
Prevents reabsorption of bile acids from the small intestines (we excrete bile acid in stool and the body will use more cholesterol to make bile acids- lower cholesterol in the blood)