Exam 2 (Neuroendocrine + Oral Digestion) Flashcards
Two types of clinically relevant enteric interneurons
serotonergic
enkephalinergic
What do serotonergic interneurons facilitate?
effector neuron action
Serotonergic NT
serotonin
What 2 responses occur with serotonergic interneurons?
- increase peristalsis
- increase net fluid secretion
What diseases can occur involving serotonergic interneurons?
- carcinoid syndrome
- inflammatory diarrhea (salmonella)
Carcinoid syndrome is a ______ tumor that secretes _____.
neuroendocrine
serotonin
Salmonella is an inflammatory diarrheal disease that increases _____ secretion.
serotonin
Enkephalinergic interneurons overall function
establish “segmentation” pattern
What is the lay term equivalent to enkephalinergic neurons?
“gut endorphins”
What 2 responses occur from Enkephalingeric neurons?
-inhibit effector neurons of alternating segments (= promote mixing contents)
-decrease secretion & increase absorption
What are the overall 3 functions of enkephalingeric interneurons?
- slow aboral transit
- enable mixing
- increase net fluid absorption
What is Loperamide? What’s another name for it?
synthetic opiate (type of enkephalinergic interneuron)
imodium
Functions of Loperamide
mimics enkephalin
anti-diarrheal
____ NS is local while ____ is outside gut wall.
enteric
extrinsic
Which type of innervation has the dominant tone of the alimentary tract?
PSNS
Main function of PSNS innervation of extrinsic NS
promote digestion
coordinate enteric NS
3 responses to PSNS activity in extrinsic NS
- motility patterns (peristalsis)
- net fluid secretion
- vasodilation splanchnic vasculature (up blood flow to GI)
PSNS innervation = same as ______ of Enteric NS because ENS plexis = ______ neurons of PSNS
effector neurons
postganglionic
When does the SNS of the Extrinsic NS have dominant tone on alimentary tract?
fight or flight
or
in long reflex
Main function of SNS innervation of Extrinsic NS
inhibit digestion
recover fluid volume
What 3 responses occur due to the SNS of the Extrinsic NS?
- decreased motility (conserve E)
- increase net fluid absorption
- vasoconstriction of splanchnic vasc.
(SNS/PSNS) increases blood flow to GI tract while (SNS/PSNS) increases circulating blood volume.
PSNS
SNS
Cholinergic innervation of striated muscle occurs what two locations?
esophagus
external anal sphincter
PSNS is made up of what 2 neuron types?
PSNS preganglionic neurons
PSNS postganglionic neurons (interneurons + effector of enteric NS)
SNS makes up what neuron types/pathway?
CNS –> preganglionic neurons –> external ganglia –> postganglionic neurons –> gut
If the gut wall was cut off from the CNS, what NS would be intact? Which would be lost?
enteric NS intact
SNS lost
What responses would be seen if CNS cut off from gut wall?
up peristalsis
up secretion
up vasodilation
dominant PSNS control, no SNS
Long reflexes are part of the ____ nervous system.
extrinsic
What is the function of long reflexes?
regulate digesta over long intestine distances
What are the two main types of long reflexes?
stimulatory
inhibitory
What is one type of stimulatory long reflex? What organ is acted on?
gastrocolic (stomach –> colon)
What are the 4 types of inhibitory long reflexes? What organs are acted on?
- enterogastric (SI –> stomach)
- enteroenteric (SI –> SI)
- coloileal (colon –> terminal part SI)
- ileogastric (ileum –> stomach)
Stimulus of Gastrocolic Reflex
full stomach (stretch)
Response of Gastrocolic Reflex
increase colon motility = move content to rectum
What neuron type is present in all long reflexes?
GVA (general visceral afferent) –> send info to CNS
Outcome of Gastrocolic Reflex (PSNS/SNS)
up PSNS
down SNS to colon
Stimulatory Long Reflexes overall function
speed transmit of GI contents
Inhibitory Long Reflexes overall function
slow transit of Gi contents to avoid overfilling of a segment
Enterogastric reflex stimulus
digesta in upper SI
Enterogastric reflex response
inhibit gastric emptying (decrease GI motility)
Output of Enterogastric Reflex (PSNS/SNS)
down PSNS | up SNS
Stimulus of Enteroenteric Reflex
digesta in SI (distal)
Enteroenteric Reflex response
inhibit peristalsis of intestine (distal SI inhibits site oral to it to prevent overfilling)
Enteroenteric Reflex response (PSNS/SNS)
down PSNS
up SNS @ oral site
Coloileal reflex stimulus
full colon (stretch)
Coloileal reflex response
inhibit ileal emptying (decrease motility)
Coloileal reflex Output (PSNS/SNS)
down PSNS
up SNS @ ileum
Ileogastric Reflex Stimulus
full ileum (stretch)
Ileogastric reflex response
inhibit gastric emptying
Ileogastric reflex (PSNS/SNS)
down PSNS
up SNS @ stomach
What are the 4 different modes of action of GI hormones?
- endocrine
- paracrine
- neurocrine
- exocrine
Which mode of action for GI hormones are hormones secreted by nerve cell –> target cell (similar to NTs)?
neurocrine
Which mode of action for GI hormones use local diffusion –> target?
paracrine
Which mode of action for GI hormones enters the bloodstream directly –> target?
endocrine
Which mode of action for GI hormones enter the lumen –> target?
exocrine
What are the 3 main hormone families (GI peptide hormones for GI function)? By what similarities are they grouped?
- Gastrin/Cholecystokinin (CCK)
- Secretin
- Other
Grouped by amino acid composition
What are the 2 neural stimuli for gastrin?
- acetylcholine (vagus N)
- GRP (gastrin-releasing peptide)
What are the 2 luminal stimuli for gastrin?
amino acids (in gastric lumen)
gastric pH > 4
Location of Gastrin
antrum
Cell type that releases Gastrin
G cells
Mode of Action (Gastrin)
endocrine
Target organ for Gastrin
glandular stomach
Response to Gastrin
parietal cells: HCl secretion
chief cells: pepsinogen release
up GI motility
Another name for CCK
pancreozymin
Luminal stimuli for CCK
amino acids (upper SI)
fats (upper SI)
CCK Location
upper SI
Cell type than releases CCK
I cells
Mode of action for CCK
endocrine
Target organs & their responses to CCK (3)
- pancreatic acini –> secrete pancreatic proenzymes
- gallbladder –> contracts GB
- sphincter of oddi –> relaxation (bile release)
Secretin stimulus for release
H+ ions (upper SI)
Secretin Location
upper SI
What cell type releases Secretin?
S cells
Mode of Action for Secretin
endocrine
Target for Secretin
pancreatic duct