Exam 2- Neuro Flashcards
Name this type of degenerative change and what 3 etiologies may cause it?
Chromatolysis- swelling of cell body and dissolution of nissl graneules with margination of nucelus
EMN, dysautomias, copper def
What is this type of injury and 3 causes of it?
Cytoplasmic vacuolation
lysosomal storage, BSE, TSE
Define Neuronphagia
Eaten by glial cells hallmark of some viral infections
Does the CNS or PNS have a greater capacity to remylenation
PNS
Define wallarian degeneration
concomitant degeneration of axon and sheath
Causes of wallerian degenration?
trauma- disk, wobblers, abscess
Toxin- lead poisoning
Axon Swelling
Define gliosis
Proliferation of astrocytes
Swelling of astrocytes is known as?
gemistocytes -cytoplasm of swollen cells
Which cells provide support, and the myelin sheath to axons within the CNS
Oligos
What to gitter cells do and what kind of cells are they?
phagocytize debris from injured cells
microglial
Function of microglial cells?
They are the smallest cells which function as immunosurveillance and phagocytosis/ag presentation
What is the potential space around blood vessels?
Virchow Robin
What is perivascular cuffing?
Site for cell traffic and accumulaton, is the hallmark of inflammation
4 causes of edema in the brain
Trauma, infectious, toxic or space occupying lesion
Which cells are least sensitive to hypoxia?
A. Neurons
B. Microglia
C. Astrocytes
D. Oligodendrocytes
Microglia
What type of cell is this that cleans up or mops up myelin?
Myelophage
What is the etiology and MDx?
Thrombotic menigioencephalitis
Histophilus somni
Fibrinonecrotizing vasculitis and thrombosis brain
Most common post mortem change due to cerebral edema?
Cerebellar coning
White matter softening?
Leukomalacia
Grey matter softening?
Poliomalacia
Ecephalo means to involve the _____?
Brain
Myelo is involving the ______?
Spine
Infectious agents causing cerebellar hypoplasia?
BVD, Schallenberg virus , FPV
What nerve does listeria travel by?
Which part of the brain does it effect and consequence?
Trigeminal
brainstem, menigoencephalitils with microabscess, gliosis, perivascular cuffing NO’s, peridontis tooth erupt,
How does rabies spread?
Oflactory nerve
What is seen in a brain with listeriosis
Menigoencephalitis with microabscesses
PERIVASCULAR CUFFING with neutrophils
These four viruses are a cause of vasculitis
BMC
CAV
FIP
EHV
In viral infections you will typically see these cells ?
Lymphocytes and plasma cells NOT Neutrophils
A virus causing menigoencepalitis in sheep causing lympocyte cuffing?
Louping ill
This virus causes grey matter inflammation of the brain and spinal cord this term would also be know as?
acute polioencephalomyelitis