Endocrine Flashcards
Where do glucocorticoids and ACTH ACT?
Zona Fasciculata and Zona reticularis
Where do mineralcorticoids and angiotension act?
Zona Gomerulosa
Where do most ACTH secreting tumors in dogs arise from?
Zona Fasciculata
In cushings disease what happens to the other adrenal gland?
It will have cortical atrophy due to negative feedback mechanism.
What is the pathognomonic sign in cushings disease?
Calcinosis cutis
What are some things you see with excess cortisol production?
Calcinosis cutis Hepatomegaly- steroid hepatopathy Hypertension Immunosupression-pyoderma, stinky Poor healing muscle atrophy Pu/Pd
What causes a pot belly?
Muscle atrophy, fat redistribution, hepatomegaly
Do all adrenal tumors cause cushings disease?
No , only functional tumors
What is Conns syndrome and what species is it seen in?
Cats It is hyperaldosteronism caused by the zona glomerulosa
In ferrets what will adrenal tumors secrete?
Ferrets have hyper estorgenism secreting Androgens not Cortisol
Clinical signs seen in ferrerts with hyper estrogenism ?
Vulvular enlargement, anemia, endometrial hyperplasia, Pu/Pd , alopecia
What is this an example of?
Adrenocortical adenoma/ adrenocarcinoma
What is going on here and what is it caused by?
Bilateral adrenocortical hypertrophy/hyperplasia, which is caused by a pitutary adenoma
What would a pitutary adenoma be secreting?
ACTH
Are these functioning adrenal tumors?
No these are nodular , this is indicative of senile change and can be from old age. This is NOT productive