Endocrine Flashcards

1
Q

Where do glucocorticoids and ACTH ACT?

A

Zona Fasciculata and Zona reticularis

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2
Q

Where do mineralcorticoids and angiotension act?

A

Zona Gomerulosa

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3
Q

Where do most ACTH secreting tumors in dogs arise from?

A

Zona Fasciculata

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4
Q

In cushings disease what happens to the other adrenal gland?

A

It will have cortical atrophy due to negative feedback mechanism.

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5
Q

What is the pathognomonic sign in cushings disease?

A

Calcinosis cutis

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6
Q

What are some things you see with excess cortisol production?

A

Calcinosis cutis Hepatomegaly- steroid hepatopathy Hypertension Immunosupression-pyoderma, stinky Poor healing muscle atrophy Pu/Pd

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7
Q

What causes a pot belly?

A

Muscle atrophy, fat redistribution, hepatomegaly

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8
Q

Do all adrenal tumors cause cushings disease?

A

No , only functional tumors

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9
Q

What is Conns syndrome and what species is it seen in?

A

Cats It is hyperaldosteronism caused by the zona glomerulosa

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10
Q

In ferrets what will adrenal tumors secrete?

A

Ferrets have hyper estorgenism secreting Androgens not Cortisol

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11
Q

Clinical signs seen in ferrerts with hyper estrogenism ?

A

Vulvular enlargement, anemia, endometrial hyperplasia, Pu/Pd , alopecia

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12
Q

What is this an example of?

A

Adrenocortical adenoma/ adrenocarcinoma

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13
Q

What is going on here and what is it caused by?

A

Bilateral adrenocortical hypertrophy/hyperplasia, which is caused by a pitutary adenoma

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14
Q

What would a pitutary adenoma be secreting?

A

ACTH

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15
Q

Are these functioning adrenal tumors?

A

No these are nodular , this is indicative of senile change and can be from old age. This is NOT productive

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16
Q

In horses what is cushing disease caused by?

A

Pituitary adenomas are from pars intermedia

17
Q

Why are clinical signs in the horse different from the dog?

A

Because in the horse clinical signs are not a result of ACTH secretion generally it is from compression of the hypothalmus which causes clinical signs

18
Q

True or false in horses with pars intermedia you will see adrenocortical hyperplasia?

A

False NO adrenaocortical hyperplasia

19
Q

What is going on here and what does this result in?

A

rathkes pouch pituitary cyst resulting in pituitary dwarfism

20
Q

What disease will be seen in primary bilateral adrenocortical atrophy?

A

Hypoadrenocorticism- Addisons disease

21
Q

What type of tumor is this and where does it orginate from?

A

Pheochromocytoma which is a neuroendocrine tumor of the adrenal medulla

22
Q

What is happening in this picutre and what disease might be seen?

A

Adrenocortical atrophy, addisons

23
Q

This goat has this disease______which is know as thyroid______.

A

Goiter, thyroid hyperplasia

24
Q

True or false in goiter animals are hyperthyroid?

A

False hypo or euthyroid

25
Q

What woud you see on histo in thyroid hyperplasia?

A

Increase in thyroid follicles, proliferation and no colloid

26
Q

True or false: All proliferative lesions result in hyperfunction?

A

False

27
Q

What can decrease T4?

A

Lack of iodine

Brassica plants, sulfonimides

Excess dietary iodide

Lack of iodine

Interfearnce with production

28
Q

What lesions causeHYPOthyroidsm?

A

lymphocytic thyroiditis

thyroid atrophy

pitutary adenoma

thyroid carcinoma

29
Q

These two signs would be seen in severe hypothyroidsm

A

Myxedema, atherosclerosis

30
Q

Lesions underlying hyperthyroidism in cats?

A

Nodular adenomatous thyroid hyperplasia 70% bilateral

31
Q

Causes of SECONDARY Hyperparathyroidism

A

High P/ Low Ca

Renal disease - high P, low calcitriol

Inadequate D3

32
Q

Cause of primary hyperparathyroidism?

A

PTH producing Neoplasia

33
Q

Causes of Pseudoparathyroidsm

A

PTH-RP producing neoplasms Ex: adenocarcinoma, lymphoma

34
Q

In pseudo hyperparathyroidsim will PTH be increased or decreased?

A

It will be decreased because of negative feedback and you will have increased Ca

35
Q

In a pancreatic islet cell carcinoma with a beta cell tumor will you see increased or decreased insulin?

A

Increased leading to hypoglycemia

36
Q

In diabetes mellitus due to pancretic hypofunction will insulin be increased or decreased? Glucose increased or deacreased?

A

Decreased insulin increased blood glucose

37
Q

What is going on with this cats pancreas?

A

Amyloidosis , results in islet cell atrophy, insulin deficiency , can be seen in cats without DM monitor

38
Q

Associated lesions with diabetes mellitus

A

Microangiopathy

Nephropathy

Retinopahty

Gangrene

Cataracts in dogs