Exam 2 - Liver Problems Flashcards
Major Functions of the Liver
Metabolism and storage
Blood volume reservoir
Blood filter (cutfirst cells)
Blood clotting factors (prothrombin and fibrinogen)
Drug metabolism and detoxification
What does the liver metabolize and store
Fat, CHO, PRO, vitamins and minerals
Lobes of the Liver
Functional units of the liver. made of hepatocytes arranged around a central vein. One of only cells that can regrow and regenerate. Can regrow from healthy liver tissue
Cutfirst cells
Line inner liver capillaries (sinusoids). Responsible for removing bacteria from blood
Portal circulation
The portal circulatory system brings blood to the liver from the stomach, intestines, spleen, and pancreas
blood enters the liver through
the portal vein
the absorbed products of digestion
come directly to the liver and are sent to the lobules
portal circulation is
the first pass effect
Liver function tests
AST, ALT, alk phos
dont worry about them until over 150
Jaundice
caused by increased level of bilirubin in the bloodstream
Jaundice usually causes problems
Is noticeable with total bilirubin is greater than 2-2.5.
Jaundice look at
look at conjugated versus unconjugated to determine possible cause
what is jaundice
yellowish discoloration of skin and deep tissues
three classifications of jaundice
hemolytic, hepatocellular, obstructive
Hemolytic jaundice
from increased breakdown of RBCs
Hepatocellular jaundice
from liver unable to take up bilirubin from blood or unable to conjugate it
Obstructive jaundice
from decreased or obstructed flow of bile (gallstones)
Bilirubin
by product of heme breakdown - mainly hemoglobin
Direct
conjugated
Indirect
unconjugated
Elevations of indirect bilirubin
bilirubin overproduction or impaired liver functioning (hemolytic)
Elevations of direct bilirubin
liver working but cant get bilirubin out (obstruction, gallstones)
Jaundice clinical manifestations
darker urine
elevated liver enzymes
stools are normal or clay colored (depends on direct or indirect)
pruritis
Viral hepatitis
systemic virus that mainly affects liver - causes inflammation
Various strains
HAV, HBV, HCV – rarer viruses caused by Epsten-Barr, cytomegalovirus
Hepatitis can occur from other causes
Alcohol abuse, drugs, chemical, bacteria
Viral Hepatitis Pathogenesis
Viral infection >
Immune response: inflammatory mediators >
Lysis of infected cells >
Edema and swelling of tissue >
Tissue hypoxia >
Hepatocyte death! – Liver failure
Clinical manifestations of viral hepatitis
Similar between all types
Many are asymptomatic - but can range from none to mild to liver failure
causes abnormal elevated LFTs - but NOT consistent with cellular damage within the liver - trend and know patient
Prodromal phase
2 weeks after exposure
fatigue, anorexia, malaise, nausea, vomiting, HA hyperalgesia, cough, low grade fever
HIGHLY transmissible
What is hyperalgesia
increased sensitivity to pain