Exam 2 Lipid Drugs

Question 1

cholesterol

Answer 1

waxy fat made in the liver obtained by food that builds up cell membranes

Question 2

LDL

Answer 2

low density lipoprotein

Question 3

HDL

Answer 3

high density lipoprotein

Question 4

triglycerides

Answer 4

main components of body fat

Question 5

hyperlipidemia

Answer 5

high levels of lipids (cholesterol)

Question 6

dyslipidemia

Answer 6

low/abnormal levels of lipids (cholesterol)

Question 7

hypertriglyceridemia

Answer 7

elevated triglycerides

Question 8

atherosclerosis

Answer 8

thickening or hardening of arteries

Question 9

HMG-CoA reductase inhibitors

Answer 9

antihyperlipidemic drug class that ends with -statin; 1st line drug

Question 10

high intensity HMG-coA inhibitors

Answer 10

atorvastatin (40-80 mg) and rosuvastatin (20-40mg)

Question 11

HMG-CoA MOA

Answer 11

inhibits the enzyme that makes cholesterol, which means less cholesterol is formed

Question 12

high-intensity LDL

Answer 12

atorvastatin and rosuvastatin

Question 13

Important Counseling for HMG-CoA inhibitors

Answer 13

can cause muscle pain, joint pain, elevated liver function tests, rhabdomyolysis

Question 14

rhabdomyolysis

Answer 14

rare muscle injury where muscle injury and can cause kidney damage

Question 15

myalgia

Answer 15

muscle pain or weakness

Question 16

arthralgia

Answer 16

joint stiffness and pain

Question 17

which HMG-CoA inhibitors work best when taken at night?

Answer 17

fluvastatin, lovastatin, simvastatin

Question 18

Crestor

Answer 18

rosuvastatin

Question 19

Lipitor

Answer 19

atorvastatin

Question 20

Zocor

Answer 20

simvastatin

Question 21

Pravachol

Answer 21

pravastatin

Question 22

Mevacor

Answer 22

lovastatin

Question 23

Livalo

Answer 23

pitavastatin

Question 24

Lescol

Answer 24

fluvastatin

Question 25

cholesterol absorption inhibitors

Answer 25

2nd line LDL reduction

Question 26

cholesterol absorption inhibitors MOA

Answer 26

inhibits absorption of cholesterol in small intestine

Question 27

Important Counseling for cholesterol absorption inhibitors

Answer 27

-do NOT use if you have liver disease
-only use this as a monotherapy if patient can’t tolerate statin

Question 28

ezetimibe

Answer 28

Zetia

Question 29

PCSK-9 inhibitors

Answer 29

-third line drug for LDL

Question 30

PCSK-9 inhibitors MOA

Answer 30

removes more LDL by preventing free PCSK9 enzymes from binding LDL receptors

Question 31

PCSK-9 inhibitors administered

Answer 31

subcutaneous injection every 2 weeks or once monthly

Question 32

Counseling for PCSK-9

Answer 32

diarrhea, myalgias, injection-site

Question 33

Praluent

Answer 33

alirocumab

Question 34

evolocumab

Answer 34

Repatha

Question 35

siRNA agent MOA

Answer 35

catalytic breakdown of mRNA, increases LDL uptake, and lowers LDL levels

Question 36

inclisiran

Answer 36

Leqvio

Question 37

indications for siRNA agent

Answer 37

heterozygous familial hyper cholesterol and ASCVD on maximally tolerated statin dose

Question 38

Dosing info for siRNA agent

Answer 38

284 mg as an injection every 3 months

Question 39

Counseling for siRNA agents

Answer 39

cause injection site reaction, arthralgia, diarrhea

Question 40

ANGPTL3 inhibitor indication

Answer 40

add-on therapy in homozygous familial hypercholesterolemia

Question 41

ANGPTL3 dosing info

Answer 41

given as an IV infusion every 4 weeks

Question 42

Counseling for ANGPTL3

Answer 42

hypersensitivity, infusion reactions, dizziness, limb pain, fetal harm

Question 43

Bile Acid Sequestrants

Answer 43

4th line LDL lowering

Question 44

Bile Acid Sequestrants for MOA

Answer 44

binds with bile acids in the intestine causing the liver to pull cholesterol from the blood, which