EXAM #2: HIV II Flashcards

1
Q

When does most perinatal transmission of HIV occur?

A

During vaginal delivery

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2
Q

When in a pregnancy is there the highest risk for vertical transmission of HIV? What are the implications?

A

Late in third trimester

*Screen/ diagnose HIV early in mother and treat her

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3
Q

What are the precautions that are taken to prevent perinatal transmission of HIV?

A

1) HAART to Mom
2) Post-exposure prophylaxis to baby
3) Consider c-section?

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4
Q

At what CD4 T-cell count can secondary syphilis occur?

A

Any CD4 count

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5
Q

How does the rash on the thorax/ palms-soles compare to a condyloma lata?

A

Condyloma lata= raised lesion that is FULL of treponema

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6
Q

How is PCP diagnosed in AIDS patients?

A

Bronchoalveolar lavage

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7
Q

What is the first line treatment for PCP in AIDS?

A

TMP-SMX

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8
Q

What is the difference between primary prophylaxis and secondary?

A
Primary= no disease, trying to prevent it 
Secondary= had disease, want to prevent it from coming back
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9
Q

What is late diagnosis of HIV?

A

Patient is diagnosed with HIV when they already have AIDS

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10
Q

Why do you want to have patients with HIV diagnosed early vs. late?

A

Early diagnosis= normal life-expectancy IF compliant

Late diagnosis= 10-30 years of life-lost

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11
Q

When do you start primary prophylaxis for PCP?

A

CD4+ less than 200

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12
Q

When do you start primary prophylaxis for toxoplasmosis?

A

CD4+ less than 100

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13
Q

When do you start primary prophylaxis for MAC?

A

CD4+ less than 50

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14
Q

What are the guidelines for starting HAART or cART?

A

Any HIV+ patient should be treated

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15
Q

What drug is the CCR5 inhibitor?

A

Maraviroc

*Note that this CANNOT be used for a R4 trophic virus

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16
Q

If a drug blocks gp41, what is its mechanism of action?

A

Fusion inhibitor

17
Q

What is the general mechanism of action of the NRTIs and NNRTIs?

A

Inhibition of reverse transcriptase

18
Q

What two drugs are used for PrEP and post-exposure prophylaxis?

A

1) Tenofovoir

2) Emtricitabine

19
Q

What drug requires HLA genomic testing?

A

Abacavir

*If positive, could develop life-threatening anaphylaxis

20
Q

What is IRIS?

A

Immune Reconstitution Inflammatory Syndrome

*Atypical inflammatory disorders associated with immune recovery

21
Q

What NNRTI is teratogenic?

A

Efavirenz

22
Q

What is the adverse effect associated with protease inhibitors?

A

Decrease the efficacy of birth control

23
Q

What three things can AIDS increase the risk for?

A

1) Metabolic syndrome/ dyslipidemia
2) Cardiovascular disease
3) Squamous cell carcinoma of the anus