Exam 2: Biocompatibility

Question 1

how the material interacts with the host in that environment

Answer 1

biocompatibility

Question 2

the interrogation of the host and subsequent reactions of the biomaterial happen at the
_____ between the ___ and the ________

Answer 2

interface, host, biomaterial

Question 3

Modern biomaterials are of the ____ generation of

biomaterials or bioinert biomaterials

Answer 3

first

Question 4

____________ are those that almost do not react when interrogated by the surrounding biological tissues

Answer 4

bioinert biomaterials

Question 5

They are biocompatible by _______ to the

tissues. They are not ___________ of tissues, either

Answer 5

not being harmful; positive to the regeneration

Question 6

_____ for dental implants is a good example of a bioinert biomaterial

Answer 6

Titanium

Question 7

The second generation of biomaterials or bioactive biomaterials was initially used around ____
years ago and ______ are nowadays used

Answer 7

10-15, only a few

Question 8

example of bioactive material

Answer 8

calcium phosphate, release of F from glass-ionomer cements

Question 9

the third generation of biomaterials or ______ materials is the _____ of biomaterials and
represents a change in the paradigm of how man-made materials can help to _____ biological
tissues

Answer 9

regenerative, future, restore

Question 10

biocompatibility is _____ to assess

Answer 10

difficult

Question 11

harmful/negative effects to be tested

Answer 11

• irritant
• toxic
• allergenic
• mutagenic
• teratogenic
• carcinogenic

Question 12

standards test that has 19 different standards

Answer 12

ISO 10993 series

Question 13

_____ has guidelines/regulations that a biomaterial/device should follow
to be used in the USA

Answer 13

FDA

Question 14

biocompatibility definition by William

Answer 14

the ability of a material to elicit an
appropriate biological response in a given
application

Question 15

biocompatibility is not an _____ property of a biomaterial

Answer 15

intrinsic

Question 16

current concepts in biocompatibility

Answer 16

• no synthetic material are inert in the body
• complex interactions occur
• result is a biological response

Question 17

biocompatibility aspects

Answer 17

• application/function
• material
• host

Question 18

concern for biocompatibility is for ____ and ______/___

Answer 18

patient, dental/manufacturer workers

Question 19

positive aspect testing

Answer 19

1. can materials be of positive benefit?

2. will it change its structure/composition while in use?

Question 20

3 positive aspects

Answer 20

1. fluoride releasing
2. induction of bone regeneration
3. tissue engineering/regenerative materials (scaffolding material)

Question 21

A material may have a ________

effect on the tissues rather than _____ _______ acute reaction

Answer 21

long-term, sub acute; readily observable

Question 22

______ are more a potential source of

biocompatibility issues than ceramics. _____ are more inert

Answer 22

polymers/metals, ceramics