Exam 2, B12 Flashcards
B12 coenzyme
B12
B12 and antibiotics
antibiotics grow animals by inhibiting growth of microorganisms that destroy B12
so increased antibiotics = increased B12
what does intrinsic factor do
protein IF made in stomach, helps intestines absorb B12
measure of B12 status
transcobalamin II (transport protein)
MAIN function B12
coenzyme that is used for the transfer of methyl groups, such as in folic acid -> THF
secondary function B12
overall growth factor, anemia prevention
methionine synthase
needs B12 for conversion of homocysteine to methionine
methylmalonyl-coA mutase
conversin of L-methylmalonyl to succinyl-CoA
odd chain fatty acids and B12
B-oxidation uses B12 to enter the kreb’s cycle through succinyl coA to produce energy
photo black and white, on top large, darker blood cells and on the bottom small, light blood cells
- pernicious anemia (top) : B12
- normal anemia, iron deficiency or microcytic anemia : iron, folte