Exam 2: Antiretrovirals (Moniri)

Question 1

nucleoside

Answer 1

base + sugar (ribose)

Question 2

nucleotide

Answer 2

base + sugar + 3 phosphates

Question 3

When RT is makes dsDNA, it is grabbing

Answer 3

nucleoTIDES

Question 4

What is the responsibly of the phosphates in nucleoTIDES?

Answer 4

bonding the strands together vertically

Question 5

When RT or DNA polymerase takes a nucleotide to make a new chain it adds the nucleotide in and takes the _____ phosphate and adds it to ____________ from the base before (this is how the bases are connected)

Answer 5

first; the free 3’ end of the ribose sugar

Question 6

T/F All nRTIs will be nucleoSIDE based, but before they work then MUST be phosphorylated

Answer 6

TRUE

Question 7

MOA of nRTIs (2)

Answer 7

• compete w/ endogenous nucleotides for place on RT

- obligate chain termination

Question 8

HLA-B27 or HLA-B57

Answer 8

slower progression to AIDs

Question 9

HLA-B35

Answer 9

Faster progression to AIDs

Question 10

-
-

Answer 10

• fully synthetic
• have not activity against HIV-2
• do NOT require phosphorylation

Question 11

MOA: bind ALLOSTERICALLY on RT –>shifts the conformation, so nucleotide can’t fit into site of action–> inhibit RT

Answer 11

NNRTIs