exam 2 Flashcards
Prevalence MDD in US according to lecture
- 16.2%, 2x as common in women, 3x as common in poverty
What to rule out when assessing depression - as discussed in the lecture-
Physical conditions (thyroid), Bipolar, substance induced mood disorder, biological components
Structured Interview and Self-Report Questionnaire for Depression
- mentioned in lecture- used to assess symptoms: Structured=Hamilton Rating Scale for Depression, therapeutic session, verbal communication, can be ambiguous, self report questionnaire= Beck’s Depression Inventory II- standardized, shows deviation from norm- how do we know people are telling the truth- difficult to study because of accuracy issues
Major Depressive Disorder (MDD)
- including symptoms of a major depressive episode- at least 1 Major depressive Episode, has experienced normal mood, can have anxiety but not hypomanic, significant distress/impairment, no other cause (medical, psychotic, substance). MDE symptoms: must have 5 for 2 weeks with depressed mood or loss of interest
1. Depressed Mood
2. Loss of Interest/pleasure
3. Appetite/Weight change
4. Sleep change
5. Psychomostor agitation/retardation
6. Fatigue/loss of energy
7. Worthlessness/guilt
8. Difficulty concentrating/indecisiveness
9. Thoughts of Death/Suicide
Persistent Depressive Disorder
- aka chronic depression, dysthymia, depressed mood most of the day, most days, 2 years, must have two or more of following symptoms, never without for more than 2 mos
- poor appetite/overeating
- insomnia/hypersomnia
- low energy/fatigue
- low self-esteem
- poor concentration/difficulty making decisions
- feelings of helplessness
Disruptive Mood Dysregulation Disorder
- severe, recurrent, tantrums- 3per week, negative mood most of day, most days, present in two settings for at least 12 months, dx between 6-18, symptoms present before age 10
Premenstrual Dysphoric Disorder
- in most menstrual cycles during past year, 5 symptoms were present in final week before menses and improved within a few days of onset. Cause significant distress or interference in functioning
- Mood Swings
- Irritability, anger, conflicts
- Depressed Mood/Helplessness
- Anxiety/on-edge
- Decreased Interest
- Difficulty Concentrating
- Lack of energy
- Changes in appetite
- Sleeping too much or too Little
- Subjective sense of overwhelmed/out of control
- Physical symptoms/bloating
Postpartum Depression
- know what this is as described by the text.- 13% of women, caused by hormonal imbalance/social isolation, stress peripartum, depression/anxiety peripartum,history of depression
Understand CBT for depression
(Cognitive Therapy and Behavioral Activation Therapy). Note that these therapies have demonstrated the most empirical effectiveness in treating depression. BAT- increases activity in lateral frontal dorsal area- do fun stuff every day with a coach- Levinson, 70’s
Main biological treatments for depression outside of medication?
- Electroconvulsive therapy, transcranial magnetic stimulation (less troublesome, but less effective), liglight therapy (seasonal- resets circadian rhythms, increased photon absorbtion, production of melatonin)
Classes of depression medications? Which came first? Which is most commonly used today?
MAOI’s- 1957, diet restrictions, now last resort. Work by breaking down norep, serotonin, tyramine, can spike BP. Tricyclics- also in 50’s, too many side effects, still used if SSRI’s don’t work. Blocks Ach, inc Norep, serotonin. SSRI’s- 1980’s, block reabsorption of Seratonin Novel Antidepressants (Wellbutrin)- work on dopamine & norep, may increase anxiety (stimulating)
Understand relationship between psychotropic medications, BDNF and neuroplasticity.
- BDNF Protein- support growth of new neurons in the brain, depression is correlated with a decrease in the production of BDNF, antidepressants and exercise increase BDNF . Anti-depressants combined with BAT & CBT can support growth in brain areas that support happiness & motivation
Know the neurotransmitters implicated in depression.
- deficiency of serotonin, norep
Define treatment resistant depression
- two trials of meds don’t work. 30-60% first trial doesn’t work, 15-33% multiple interventions don’t work, 20-50% of patients are nonadherent- ECT, TMS, light tx, sleep tx, limit blue light, sleep in cool environment
Define Circadian Rhythm and know methods for balancing it
- daily rhythm, sleep clock, can cause sleep disturbances, trigger manic episodes, tx= light box, melatonin 3 hrs before sleep- establish night ritual
Understand reasons behind mindfulness meditation for depression
- decreases anxiety, decreases rumination about past, leads to increase in activity in left frontal lobe (related to happiness)
Understand Seasonal Depression and light therapy treatment
- 1 ½-2 hrs daily, inc serotonin levels, increased photon absorbtion, balancing of circadian rhythm and melatonin levels
Know endogenous and exogenous depression as defined in the text.
- exogenous (reactive) depression from reacting poorly to environmental stressors. Endogenous depression is genetically/biologically oriented- little link to environmental causes
Bipolar I
- at least 1 manic episode (plus more is okay), rule out other disorder, may be rapid cycling or have psychotic features. Usually 3 episodes/year (more is rapid cycling), ultracycling can happen in same day, delusions/hallucinations=psych features. Symptoms: abnormally inflated/irritable mood and increased activity not caused by a substance + 3 (+4 if mood is irritable)
1. grandiosity
2. decreased need for sleep
3. very talkabive/pressured speech
4. flight of ideas
5. distractability
6. Increased goal-directed activity
7. Excessive involvement in pleasurable activities that have high potential for negative consequences
Bipolar II
- 1 hypomanic episode, 1 major depressive episode, not another disorder
Cyclothymia
- hypomanic/depressive symptoms, no major episodes, 2 years, (1 yr in kids), significant distress/impairment, not due to other disorder
Know the definition of Euphoria as defined by the text.
- short term intense happiness, when lingers leads to grandiosity/mania (far end of happiness/euphoria continuum)
Understand and be able to distinguish between manic and hypomanic episodes-
Manic 1 week, has distress/impairment in functioning/psychotic features
Hypomanic- 4 days, less severe, no impairment, no hospitalization, no psych features, but is a change in functioning noticeable to others
Understand Rapid Cycling specifier of bipolar (how many cycles/ yr compared to typical bipolar?)
- typical is 3 episodes/year, more is rapid cycling, or even ultracycling
Neurotransmitters related to Bipolar
- low serotonin & high norepinephrin
Bipolar medications are called?
- Mood stabilizers, lithium, may be combined with anticonvulsants, antipsychotics or even antidepressants (careful not to trigger manic episode)
Connection between substance use and suicide?
- 30% of suicides are under influence at TOD