Exam 2 (3/29) Flashcards

1
Q

Review s/s of toxicity related to alteplase (Activase)

A
●	BLEEDING (can cause a serious GI bleed)
●	Angioedema
●	Hypotension
●	Recurrence of VTE
●	Anaphylaxis and fever 
●	Cholesterol embolization
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2
Q

Know the administration technique of enoxaparin (Lovenox)

A

● Administer subQ in a prefilled syringe
● One-time use syringe
● Do NOT expel the air bubble from the syringe before administering, Administer the air bubble in the pre-filled syringe
● Monitor for excessive bleeding and bruising

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3
Q

Review the therapeutic levels of PT and INR in regards to warfarin (Coumadin) therapy

A

● PT Normal Levels: 11-13 seconds
○ PT Therapeutic Levels: 18 seconds to 24 seconds
● INR Normal Levels: 1.1 or below
○ INR Therapeutic Levels: 2.0-3.0 with average of 2.5 KNOW THIS
■ For those with recurring clots 2.5-3.5 with an average of 3.0

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4
Q

Identify AE’s of heparin induced thrombocytopenia

A
●	pt has a platelet count that continues to drop significantly with increased thrombi 
○	Type I
■	Gradual reduction in platelets
■	Heparin therapy can generally be continued. 
○	Type II
■	Acute fall in number of platelets (more than 50% reduction from baseline)
■	Discontinue heparin.
○	Clinical manifestations
■	BLEEDING RISK
■	Thrombosis that can be fatal.
■	Bruising
■	Petechiae
■	Hematomas
■	black/tarry stools
■	Calf pain 
■	Tenderness 
■	Swelling
■	Shortness of air
●	 Toxicity:
○	 Discontinue heparin immediately – give antidote
○	Antidote to heparin is IV protamine sulfate
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5
Q

Review contraindications for antilipemic drugs

A
●	Try non drug means for cholesterol levels for 6 months before drug is considered
●	High cholesterol… over 300 (more at risk for coronary heart disease)
●	Allergy
●	pregnancy
●	liver disease
●	elevated liver enzymes
●	Cirrhosis
●	gallbladder disease
●	Interventions:
○	Baseline liver function
○	Obtain CPK if muscle pain occurs
○	Dietary patterns, exercise, tobacco
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6
Q

Know patient teaching for gemfibrozil (Lopid)

A

● Treats type III, IV, and V hyperlipemia
● May increase the risk for gallstones so avoid fried, fatty foods
● Can cause GI discomfort, N/V/D
● Must attempt lifestyle changes for 6 months before beginning therapy
● Need to have periodic liver function labs done

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7
Q

Identify AE’s of atorvastatin (Lipitor)

A
●	Myopathy (rhabdomyolysis)
●	GI disturbances
●	Headache
●	Rash
●	Dizziness
●	blurred vision
●	Fatigue
●	insomnia
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8
Q

Know contraindications for atorvastatin (Lipitor)

A

Drug allergy
● Pregnancy
● liver disease
● elevated liver enzymes

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9
Q

Know AE’s of albumin

A

● Impaired coagulation

● bleeding

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10
Q

Review indications of sodium chloride

A

● Hypovolemia, dehydration
● Manage F & E imbalances
● Promote urinary flow

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11
Q

Know contraindications for the use of potassium

A

● Hyperkalemia

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12
Q

Review contraindications for thyroid replacement drugs

A

● Recent MI
● Drug allergy
● Adrenal insufficiency
● Hyperthyroidism

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13
Q

Know the time length of when therapeutic effects occur for thyroid replacement drugs

A

● Takes several weeks for therapeutic effects to be seen

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14
Q

Identify important teaching to the client prescribed thyroid replacement drugs – levothyroxine (Synthroid)

A

● It has a long half life, so once a day dosing… oral or IV
● Take it at the same time everyday, before breakfast (empty stomach- wait at least 30 minutes)
● Therapeutic effects take several weeks to occur
● Do not switch generic and brand name
● Dose in mcg (easy to make dosage mistake)

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15
Q

Review the instructions/teaching provided to clients who receive radioactive iodine-131.

A

● CONTAGIOUS WHEN RECEIVING TREATMENT!!
● Can contaminate others: saliva, urine
● Avoid sexual contact, sleeping in same bed as others, having close contact with children or pregnant women, and sharing utensils/cups.
● Contraindicated during pregnancy & lactation (cannot conceive for 6 months after treatment)
● Usually only on it for a short period of time

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16
Q

Know the major adverse effects of antithyroid drugs – propylthiouracil (PTU) – and how a nurse should monitor for these adverse effects.

A

● Upset stomach: dose with meals
● Agranulocytosis: low WBC
○ Fever, sore throat, unusual bleeding, skin breakdown
○ monitor CBC at baseline and periodically there after
○ Stop therapy if seen
● Liver and bone marrow toxicity
● Propylthiouracil (PTU)- 2 weeks of therapy needed before symptoms improve

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17
Q

Understand the rationale as to the importance of tapering off the dose of corticosteroids.

A

● Adrenal suppression can happen
○ Adrenal glands naturally secrete hormones, but once you take corticosteroids your adrenal glands stop making as much- this leads to addison’s crisis
○ Tapering off = waking adrenal glands back up

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18
Q

how to properly prepare and administer parenteral (IV) methylprednisolone (Solu-Medrol).

A

● Push on top to break the seal
● Mix the powder and solution a little bit
● Break off small top piece and clean with alcohol swap
● Shoot air into the vial and then draw back what you need
● Get rid of air/air bubbles and administer
give over 30 minutes

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19
Q

Know the adverse effects associated with corticosteroid/adrenal drugs.

A

● Most important: moon face, hyperglycemia and psychosis, adrenal suppression
● Glaucoma
● cataracts
● Increased risk of infections, especially with common bacterial, viral and fungal microorganisms
● Thinning bones (osteoporosis) and fractures
● Thin skin, bruising and slower wound healing

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20
Q

Know the adverse effects of fludrocortisone (Florinef) and which types of clients it could be contraindicated in.

A
●	Adverse effects: r/t water retention
○	Heart failure
○	HTN
○	Increased intracranial pressure
●	Contraindicated: systemic fungal infection
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21
Q

Know the indications of use for proton pump inhibitors

A

● Erosive esophagitis
● GERD
● Ulcers in the stomach: Duodenal and gastric ulcers

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22
Q

Know the adverse effects of long term use of proton pump inhibitors

A

● Osteoporosis: get regular bone density screenings to monitor for bone loss
● C. diff
● Pneumonia
● Magnesium depletion

23
Q

Know the correct timing of administration of sucralfate (Carafate)

A

● Give 4 times a day on empty stomach
○ 1 hour before usual 3 meals and again at bedtime
● Do not give antacids within 30-60 minutes of administration
● Take all other meds 2 hours before administration

24
Q

Review client education regarding contraindications for misoprostol (Cytotec)

A

● Given orally 4 times a day with meals while patient is taking NSAID therapy
● Confirm nonpregnant state before starting
○ Teach women of childbearing age to use contraception during drug therapy
● Monitor for severe diarrhea and abdominal pain
● Monitor for excessive menstrual pain or midcycle bleeding

25
Identify contraindications of laxative use
● Bulk forming: Esophageal or GI obstruction, fecal impaction, dysphagia, N/V, appendicitis, undiagnosed abd pain ● Stool softener: GI obstruction, perforation, concurrent use of mineral oil, fecal impaction, N/V, undiagnosed abd pain ● Stimulant: Children younger than 1 year, GI obstruction/perforation, anal or rectal fissures, ulcerated hemorrhoids, fecal impaction, ileus, undiagnosed abdominal pain
26
Review nursing interventions related to antidiarrheal opiates
● Give hard candy ● Give them water ● Monitor for lightheadedness when walking ● Recommend lowest dose possible for the shortest time possible ● Monitor for anticholinergic effects ○ Dry mouth, urinary retention/constipation, less sweating, increased HR, dilated pupils, blurred vision ● Monitor urinary elimination patterns ● Loperamide (Imodium A-D) ○ Initial dose of 4 mg, follow each loose stool with 2 more mg. Do NOT exceed 16mg/day ○ Stop after 48 hours if diarrhea persists ● Diphenoxylate w/ atropine: ○ Treat overdose with naloxone (Narcan) ○ Atropine in high doses can cause unpleasant effects- so this discourages recreational use
27
Review instructions/teaching for a client prescribed psyllium (Metamucil)
● Take 1-3 times daily with at least 8 oz of fluid- very important ● Taking before meals may reduce appetite ● Expect soft, formed stools 1-3 days after beginning therapy ● Monitor I&O and bowel function ● Monitor for severe diarrhea and dehydration
28
Understand the indications for use of docusate (Colace)
● Constipation ● Prevention of fecal impaction ● Straining during defecation ● Painful elimination of hard stools
29
Know the timing after administration of each laxative prototype that a client should expect a bowel movement
● Bulk forming: 1-3 days ● Stool softener: several days ● Stimulant: 6- 24 hours, suppository is 15 minutes-1 hour
30
Review the correct administration/timing of IV ondansetron (Zofran)
● Give IV push dose up to 8 mg over 2-5 mins ● 30 mins before end of surgery ● Administer 30 mins before chemo and 4-8 hours later
31
Know adverse effects of prokinetic drugs: metoclopramide (Reglan)
● sedation, dry mouth, diarrhea, extrapyramidal symptoms (dystonia, tremor, akathisia, parkinsonism, tardive dyskinesia) ○ FALL RISK ○ Monitor for diarrhea and dehydration ○ Water, gum, and hard candy for dry mouth ● Delayed gastric emptying
32
Know adverse effects of antihistamines: dimenhydrinate (Dramamine)
``` ● Sedation, drowsiness, dizziness ○ FALL RISK ● anticholinergic effects ○ Dry mouth, retention, blurry vision, dilated pupils, increased HR, less sweating ■ Watch bowel and elimination patterns ```
33
Review instructions/teaching for a client prescribed scopolamine (Transderm Scop)
● Adverse effects – dry mouth, urinary retention, constipation ● Use gloves to administer and to take off ● Apply behind ear ○ Wash & dry area before applying ● Discontinue after 72 hours ● Recommend applying 4 hours prior to anticipated exposure to N/V
34
Review how to properly and safely administer promethazine (Phenergan) IV
● Severe tissue damage can occur if given mistakenly intraarterial ● Dilute in at least 10 mL of fluid when giving IV ● Discontinue use if burning or pain occurs with IV administration
35
Know the similarities and differences between water-soluble and fat-soluble vitamins
● Water soluble: Vitamin B1, B2, B3, B6, B12, C ○ Dissolve in water ○ Easily excreted in urine ○ Daily intake is necessary ○ Very rare to reach toxic amounts ● Fat soluble: Vitamin A, D, E, K ○ Dissolved in fat ○ Stored longer in liver and fatty tissues ○ Daily intake NOT needed unless deficient ○ Excreted via feces ○ Can reach toxic levels
36
Identify the indications for calcium supplementation
● Calcium is needed for our bones and teeth. ○ treatment or prevention of calcium depletion ○ osteomalacia ○ hyperphosphatemia ○ osteoporosis in older adults ○ mostly women ○ muscle cramps ○ pregnancy and lactation ○ children. ● Give oral dose 1-3 hours after meals
37
Know adverse effects of vitamin B2
● AE: Large doses can cause a yellow/orange discoloration of urine. Almost like a highlighter color.
38
Know the drug interactions of vitamin B6
● Interaction: Levodopa ○ When taking it with levodopa it can reduce the activity of levodopa. Levodopa is a Parkinson’s medication, so it can result in worsening Parkinson symptoms.
39
Review teaching/education for the client prescribed ferrous sulfate (Feosol)
● Ferrous sulfate (Feosol)= PO form ○ Do not crush or chew ○ Dilute liquid form, but not in milk because calcium can decrease the absorption of iron, the best liquid is orange juice. ○ Give through a straw and then rinse mouth after as this can stain the teeth. ○ Educate the patient that they may have black tarry stools when taking an iron supplement. Let them know that this is normal. We also see black tarry stools with a GI bleed, so we need to know if they are taking an iron supplement. ○ Doses will be 300 mg 2-3 times a day, we want to spread the doses evenly across waking hours (maximizes production of RBC’s). ○ Provide hard candy or gum after taking the liquid form. ○ Iron toxicity symptoms: nausea, abdominal pain, vomiting, dizziness, hypotension, headache, coma, shock, seizures. ○ The tablets look like M&Ms and taste like sugar so we must keep these away from children or it can cause iron overdose and peds poisoning deaths. ○ Give on empty stomach for best absorption, but can be given with food to decrease GI upset
40
Identify the indications for use of vitamin B12
● Pernicious anemia: lack of intrinsic factor; vitamin B12 deficiency
41
Identify the adverse effects of vitamin B12
● Major adverse effect: hypokalemia | ● Diarrhea
42
Review IV administration of folic acid (vitamin B9)
● IV form must be given SLOW (over 30-60 seconds) or add to an IV fluid infusion. ● Obtain baseline serum folate, Hgb, Hct, RBC and reticulocyte count ● Encourage daily intake of foods high in folate (green veggies, liver, some breakfast cereals, lentils) ● Teach patients to expect flushing and warmth following IV administration, yellow/orange discoloration of urine.
43
Understand the MOA of erythropoietic growth factor: epoetin alfa
● Stimulates the production of RBC’s in the bone marrow. ● Used commonly with kidney disease, preoperative anemia, chemotherapy. ● It mimics our own body’s production of epoetin, helping us raise our hemoglobin and stimulating red blood cell production. ● Black Box Warning: Increased risk for cardiovascular events, this is why it is contraindicated in patients with uncontrolled HTN. ● It is not a quick fix, its onset of action is days to weeks.
44
Understand nursing actions and monitoring needed to administer TPN
● Central line or PICC used. ● Change tubing every 24 hours ● Watch for hyperglycemia, may need insulin replacement. ● Used for prolonged periods of time (longer than 7-10 days) ● AE:Most are associated with the use of the central vein for delivery. ○ Greater potential for infection ○ Serious catheter-induced trauma and related events. ○ Greater chance for metabolic complications such as hyperglycemia due to more concentrated volumes of nutritional supplements being delivered. ● Assessment: ○ Thorough nutritional assessment: ■ Weekly and daily food intake ■ Weight and height ○ Ask about any nutritional concerns: ■ Weight gain or loss ■ Nausea, vomiting, anorexia, loss of appetite ○ Consult with registered dietician to identify nutrients missing in patient’s diet ○ Total body metabolic rate, body mass index, and muscle mass may be assessed. ● Labs: ○ Total protein level, albumin level, BUN, RBC’s WBC’s, hemoglobin, hematocrit ○ Cholesterol level, electrolytes, lipid profile. ● Before giving Parenteral Nutrition: ○ Assess allergies ○ Determine appropriate solution (with help from a registered dietician) ○ Assess patient/caregiver knowledge of central line/peripheral line: provide education to prevent infection/phlebitis ● Nursing Interventions: ○ Check the patient for s/s of hyperglycemia frequently: polydipsia, polyuria, polyphagia, HA, N/V, dehydration, weakness ○ Insulin replacement may be needed with the increase in glucose intake ○ If parenteral nutrition is discontinued abruptly, rebound hypoglycemia may occur: ■ Prevent by providing infusions of 5% to 10% glucose or D5W/D10W ○ Monitor S/S of fluid overload ○ Measure I&O as ordered
45
Review client positioning in bed and nursing actions with continuous nutritional feeding
● We want to keep the HOB elevated at least 30 degrees while feeding, pause feeding if laying patient flat. A side effect is dumping syndrome so we do not want to elevate them anymore. ● Before enteral nutrition: ○ Assess allergies ○ Assess cardiac and renal status (can a patient handle large amounts of fluid?) ○ Assess gag reflex, ability to swallow, bowel sounds ● Nursing Interventions: ○ Must have prescriber’s order BEFORE administering ○ Check for proper NG tube placement prior to each feeding ○ Aspirate gastric residual volumes BEFORE each feeding and BEFORE administration of each medication ○ Follow prescriber's orders infusion rate ○ Change tubing for parenteral feedings each time a new bag is added to the infusion and every 24 hours. ○ Adverse effect of dumping syndrome may decrease absorption of phenytoin ■ Hold tube feeding 2 hours before and 2 hours after administration of phenytoin
46
Know the adverse effects of PPN
● Iv used- watch for phlebitis (vein irritation or inflammation of a vein) ○ Can lead to loss of a limb if it is not treated appropriately ● Other AE’s: Fluid overload and avoid in patients with renal or heart failure.
47
Review client teaching/education when prescribed oral contraceptives
● Black Box Warning: Cigarette smoking increases the risk for serious cardiovascular events and cardiovascular disease ○ Risk increases with age >35 and the number of cigarettes smoke! ● Ensure understanding of how to take the drug and what to do if they miss doses. ● Importance of taking it the SAME time every day! ● If you forget to take a birth control pill, take it as soon as you remember. ● If you don't remember until the next day, go ahead and take two pills that day. ● If you forget to take your pills for 2 days, take two pills the day you remember and two pills the next day. ● Encourage smoking cessation!! ● Monitor BP and weight ● Assess for drug interactions
48
Know contraindications for hormone replacement therapy drugs
● Estrogen- dependent cancers ● Undiagnosed abnormal vaginal bleeding ● Pregnancy ● Active thromboembolic disorder or history
49
Review the nursing implications for uterine stimulants
● Pitocin: Induce or enhance labor ○ Nursing Implications: ■ Careful monitoring, can cause uterine rupture if not followed closely. ■ Assess and document BP, pulse, and respirations ■ Continuous fetal monitoring (fetal HR and contraction related fetal HR) ■ ONLY give IVPB so oxytocin is diluted and on an infusion pump ■ Report any abnormal changes in fetal HR ● Methergine: Prevents postpartum uterine atony and hemorrhage ○ Nursing Implications: Limit use in hypertensive patients ● Cervidil and Prepidil: Induce labor ○ Nursing Implications: Monitor for uterine hyperstimulation
50
Know the indications for use of magnesium sulfate
● Preterm labor | ● Pre-eclampsia and eclampsia
51
Understand the proper administration instructions for alendronate (Fosamax)
● Do not crush or chew tablet ● Do not lay down after taking this medication… sit or stand for at least 30 minutes ● Take on an empty stomach with a full glass of water
52
Review client teaching/instructions in regards to testosterone (Androderm, Androgel)
● Androderm ○ Transdermal patch ○ Mimic the normal circadian variation in testosterone concentrations, with maximum levels occurring in the early morning hours and minimum concentrations occurring in the evening ○ To be applied to back, stomach, upper arms, or thighs nightly every 24 hours ● Androgel ○ Topical gel ○ To be applied to upper arms and shoulders at the same time each morning ○ Avoid showering, bathing, or swimming for 2 hours after application
53
Know adverse effects of tamsulosin (Flomax)
● Can cause hypotension: ○ Monitor BP ○ Advise clients to rise slowly from sitting to standing
54
Know drug interactions for sildenafil (Viagra)
● Nitrates (do not take within 24 hours)