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BIOL 2230 > Exam 2 > Flashcards

Exam 2 Flashcards

1
Q

blood facts

A

only liquid tissue in the body (connective tissue)
8% of body weight (5 liters)
temperature is 100ºF
pH is between 7.35-7.45

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2
Q

functions of blood

A
  1. delivers oxygen and nutrients to tissues
  2. transports metabolic waste (CO2)
  3. transports hormones
  4. maintains body temo
  5. maintains pH (carriers a buffer, bicarbonate, that regulates pH
  6. maintains fluid volume (works with kidneys)
  7. prevents blood loss through clotting
  8. prevents infection with specialized immune cells
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3
Q

components of blood

A

formed elements (46%) and plasma (54%)

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4
Q

erythrocytes

A

red blood cells
-nonliving
-45% of formed elements

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5
Q

function of erythrocytes

A

carry respiratory gases
oxygen and CO2

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6
Q

leukocytes

A

white blood cells
-living
-less than 1% of formed elements

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7
Q

function of leukocytes

A

immunity

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8
Q

platelets

A

fragments of cytoplasm
-nonliving
-less than 1% of formed elements

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9
Q

where are all formed elements produced

A

red bone marrow

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10
Q

blood hematocrit

A

shows the percentage of each component of blood

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11
Q

plasma

A

made of 90% water volume and 10% solutes (proteins, globulins, nitrogenous waste, nutrients, electrocytes)

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12
Q

structure of erythrocytes

A

small
biconcave –> pucker on both sides
anucleate- no nucleus or other organelles
has antioxidant enzymes that get rid of accumulates free radicals

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13
Q

how many RBC do humans have?

A

5 million RBC per milliliter of blood

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14
Q

which sex has more RBC?

A

men- testosterone leads to excess production

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15
Q

how many hemoglobin molecules per RBC

A

250 million

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16
Q

oxygen and heme binding

A

each heme binds to one oxygen, so one hemoglobin molecule has 4 oxygens

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17
Q

how many oxygen molecules per milliliter of blood

A

5 million oxygen molecules

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18
Q

composition of hemoglobin

A

globin protein bound to heme pigmnet
globin is complex protein with more than one subunit
heme is pigment that makes blood red

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19
Q

globin protein subunits

A

4 polypeptide chains:
2 alpha and 2 beta
each subunit binds to one heme pigment

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20
Q

heme pigment composition

A

contains oxygen binding iron
each heme can bind to one oxygen molecule SO each hemoglobin can carry 4 oxygen molecules

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21
Q

oxi-hemoglobin

A

hemoglobin with oxygen bound
makes blood bright red

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22
Q

deoxy-hemoglobin

A

when oxygen is not bound
makes blood dark red

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23
Q

transporter mechanism for moving oxygen throughout the body

A

hemoglobin LOVES oxygen
once oxygen starts binding to hemoglobin, it is easier to bind additional oxygen
-likely to stay completely saturated

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24
Q

carbaminohemoglobin

A

hemoglobin carries some carbon dioxide
20% of CO2 in the blood is bound to hemoglobin (the rest is in plasma)
carbon dioxide doesn’t bind to heme, it binds to amino acids on the globin part

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25
Q

hematopoiesis

A

the production of blood cells (general process)
-occurs in red marrow

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26
Q

how much blood is produced per day?

A

one ounce of blood cells per day
each ounce contains 100 billion cells

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27
Q

composition of blood cell

A

varies from day to day
-when you are sick, your body produces more WBC
-when you work out, your body produces more RBC

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28
Q

erythropoiesis

A

production of red blood cells

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29
Q

timing of the process of erythropoiesis

A

takes 3-5 days and produces about 2 million erythrocytes per second

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30
Q

are reticulocytes and erythrocytes living?

A

no
thy have lost their organelles and nucleus

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31
Q

erythropoietin in regulating erythropoiesis

A

when blood is low on oxygen, the kidneys produce this hormone
body monitors oxygen level, NOT RBC count
-has receptors on hemocytoblasts, and initiates their division process

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32
Q

testosterone in regulating erythropoiesis

A

increased muscle mass results in an increased need for blood, and more RBC
works through the kidneys by stimulating them to release erythropoietin (do not directly stimulate)
why men have more testosterone than women

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33
Q

B vitamins in regulating erythropoiesis

A

B12 and folic acid increase RBC

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34
Q

why are prenatal vitamins important?

A

B12 and folic acid increase RBC, when a woman is pregnant she needs to create enough RBC for her and the baby

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35
Q

iron in regulating RBC

A

iron is needed to create hemoglobin (we get it in the food we eat- vegans and vegetarians may have low iron)

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36
Q

what happens to iron if we don’t need it immediately

A

it gets stored in cells as ferritin and hemoidesterin
-when transported in blood, it is called transferrin

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37
Q

how long do erythrocytes last?

A

last between 100-120 days

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38
Q

what happens to old erythrocytes

A

they ultimately get old and macrophages consume them and break them apart
process of breaking down occurs in the spleen

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39
Q

what happens as we break down RBC

A

we recycle their parts
-heme is split from globin
-iron is stripped off heme and stored as ferritin and hemosiderin
-heme is broken down and turned into bilirubin

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40
Q

what is bilirubin

A

heme is broken down and turned into this
it is picked up by the liver and used to make bile
bile is secreted into the small intestine and breaks down fats
pigmnet ultimately fades and is expelled into feces

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41
Q

what is globin broken down into

A

it is a protein- broken down into amino acids and used to make new proteins

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42
Q

anemias

A

low number or abnormal number of red blood cells that reduce the oxygen carrying capacity of the blood

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43
Q

polycythemia

A

overproduction of red blood cells
blood has trouble moving through tiny capillaries and blood is a sludge

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44
Q

diapedesis

A

the ability for blood cells to leave the blood vessels and enter into the interstitial fluid
**only some WBC can do this so they can function in immunity **

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45
Q

leukocytes

A

complete, living cells with nuclei and organelles
display positive chemotaxis- chemically attracted to certain areas
5 total types; some contain granules which store things such an enzymes

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46
Q

neutrophils

A

granulocyte
phagocytic cells which function in inflammatory response
most numerous of all WBC
multi-lobed nucleus
50-70% of all WBC

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47
Q

basophils

A

granulocyte
full of histamine (a vasodilator)
attact other white blood cells
stain very dark
0.5-1% of all WBC

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48
Q

eosinophils

A

granulocytes
attack parasitic worms
two-lobed nucleus
2-4% of all WBC

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49
Q

lymphocytes

A

agranulocytes
function in immunity
have a large nucleus; found primarily in lymph tissue
25% of all WBC

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50
Q

T-cells

A

type of lymphocyte that attack virally infected cells or tumors

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51
Q

B-cells

A

type of lymphocyte that secrete antibodies

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52
Q

monocytes

A

agranulocytes
largest of all WBC with a u-shaped nucleus
they leave the blood stream and become macrophages
3-8% of all WBC

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53
Q

leukopoiesis

A

production of white blood cells
hemoblast is stimulated and gives rise to TWO different types of stem cells
myeloid stem cells give rise to ALL granulocytes and monocytes
lymphoid stem cells give rise to lymphocytes

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54
Q

interleukins

A

chemical messengers usually released when fighting an infection
when a cell is atatcked by a virus, it releases these to protect neighboring cells

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55
Q

colony-stimulating factors (CSFs)

A

increases WBC count

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56
Q

leukemia

A

cancerous disorder of white blood cells

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57
Q

infectious mononucleosis

A

increase in agranulocytes
caused by exposure to Epstein-Barr virus
“kissing disease”

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58
Q

leukopenia

A

decrease in white blood cell production
immune system is compromised

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59
Q

platelets

A

anucleated cytoplasmic fragments of megakaryocytes
contains granules with clotting factors

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60
Q

thrombopoiesis

A

production of platelets

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61
Q

thrombopoietin

A

a protein which stimulates the production of platelets

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62
Q

hemostasis

A

stop bleeding
1. vascular spasm
2. platelet plug formation
3. coagulation

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63
Q

vascular spasm

A

blood vessels constrict and slow down blood flow
hemostasis ALWAYS starts with this step

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64
Q

platelet plug formation

A

platelets aggregate at the site of vascular spasm

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65
Q

why do we want limitations to platelet plug formation?

A

we only want to clot where we need it

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66
Q

PGI2 (prostacyclin)

A

from intact endothelial cells; inhibits platelet adhesion, prevents clotting

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67
Q

heparin

A

from intact endothelial cells, inhibits platelet accumulation, prevents clotting

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68
Q

vitamin E quinone

A

limits clotting
from diet, a blood thinner

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69
Q

intrinsic pathway to coagulation

A

series of reactions in which clotting factors are converted to their active forms
13 different clotting factors (you activate one, which activates the next, etc.)

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70
Q

extrinsic pathway to coagulation

A

much quicker
in addition to the platelets, the injured tissue itself is also involved in this pathway

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71
Q

clot retraction

A
  1. Fibrin mesh starts contracting the clot and the contractile proteins in the platelets allow it to pull the plug together (causes the clot to squeeze)
  2. this squeezes out the serum that was trapped inside the clot and the the clot ruptures (facilitates repair)
  3. ruptured edges of the vessel come closer together
  4. PDGF (platelet derived growth factor) stimulates vessel repair (stimulates regeneration of the damaged tissue)
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72
Q

fibrinolysis

A
  1. clot produced plasminogen, which is a plasma protein
  2. plasminogen is activated by tissue plasminogen activator (TPA) which is released by newly formed epithelial tissue (plasminogen is activated into plasmin)
  3. plasmin digests fibrin
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73
Q

clot limiting factors

A

the chemicals secreted to cause a clot to form don;t just stay at the site of injury, they get released into the bloodstream and circulate away
only where we have high concentration of these chemicals do we have clots

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74
Q

antithrombin III

A

inactivates thrombin

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75
Q

protein C

A

inhibits intrinsic pathway events (indirectly inhibits production of thrombin)

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76
Q

heparin

A

produced by intact endothelial cells, enhances activity of antithrombin III and inhibits intrinsic pathway

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77
Q

thrombus

A

stationary blood clot is too large and gets stuck (stays attached)
blocks the flow of blood in the vessels

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78
Q

embolism

A

a clot breaks free and travels through the blood stream (mobile clot)
gets stuck somewhere else in the body (commonly in heart and brain)

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79
Q

thrombocytopenia

A

pathology reduced platelets in the body (due to sickness/infection)

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80
Q

hemophilia

A

genetic disorder that doesn’t allow for the production of one or more clotting factors

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81
Q

human blood typing

A

this is hereditary
determined by the presence of agglutinogens that are markers on the surface of RBCs

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82
Q

agglutinin

A

attackers from our body
-produce attackers for the markers that we don’t have

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83
Q

agglutinogen

A

markers in our own body
determines blood type

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84
Q

Rh Factor

A

augments blood type
Rh+ or -

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85
Q

universal donor

A

type O-
can donate blood to anyone because they don’t have any antigens or agglutinogens, so another person’s antibodies wouldn’t have anything to attack

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86
Q

universal recipient

A

AB+
can receive blood transfusions from all types of blood because the person does not produce any antibodies to attack the transfused blood

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87
Q

transfusion reaction

A

occurs when agglutinins and agglutinogens interact, which leads to clumping and blood no longer circulates well

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88
Q

erythroblastosis fetalis (aka hemolytic disease of the newborn)

A

if a mother is RH- and the father is Rh+ and the baby is Rh+, the the first baby will be fine
however, because of the transfer of blood during delivery of the first baby, the mother will be exposed to the baby’s blood and will start producing anti-Rh antibodies
in all subsequent pregnancies, if the baby is Rh+ , the anti-Rh antibodies in the mother will attack the blood of the embryo resulting in a still birth

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89
Q

rhogam

A

injection that suppresses production of anti-Rh

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90
Q

mediastinum

A

compartment in the middle of the chest where the heart sits

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91
Q

base

A

what we consider the top of the heart

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92
Q

apex

A

the bottom of the heart

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93
Q

pericardium

A

double-walled sac that surrounds the heart

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94
Q

fibrous pericardium

A

functions to attach the heart to the thoracic wall
composed of dense irregular connective tissue

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95
Q

serous pericardium

A

made of parietal and visceral layers and the pericardial cavity

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96
Q

parietal layer of pericardium

A

covering of the pericardium

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97
Q

visceral layer of pericardium

A

outermost covering of the heart (directly surrounds heart)
also called the epicardium

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98
Q

pericardial cavity

A

filled with fluid to maintain the temperature and produce cushion/reduced friction

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99
Q

epicardium

A

outer layer of the heart
made of epithelial tissue

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100
Q

myocardium

A

middle layer of heart
made of cardiac muscle tissue

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101
Q

endocardium

A

inner layer of the heart
composed of simple squamous epithelial tissue which is antithrombotic (you don’t want clots for this reason)

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102
Q

atria

A

at the base of the heart

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103
Q

ventricles

A

at the apex of the heart

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104
Q

interatrial septum

A

splits the right and left atrium

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105
Q

interventricular septum

A

splits the right and left ventricles

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106
Q

coronary sulcus

A

also called the atrioventricular groove
runs between the area where the atria become ventricles
blood vessels sit here so they don’t rub on anything when the heart beats

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107
Q

interventricular groove

A

betwen the right and left ventricles
runs diagonal on the front of the heart and vertical on the back
good anatomical point to determine anterior vs posterior

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108
Q

auricles

A

external extensions of the atria that increase surface area of the atria so they can hold more blood (volume)

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109
Q

pectinate muscles

A

muscles that line the atria

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110
Q

fossa ovais

A

the remnant of the foramen ovale, which closes up as an infant

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111
Q

trabeculae carneae

A

muscles in the ventricular walls

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112
Q

papillary muscles

A

“flat”
muscles that extend into each chamber of the ventricles and hold onto the valves
have string’like extensions that join with the bell

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113
Q

vena cava

A

attached to the right atrium
empty all blood into the right atrium

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114
Q

superior vena cava

A

drains head and neck blood into the right atrium

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115
Q

inferior vena cava

A

drains bottom half of body’s blood into the right atrium

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116
Q

coronary sinus

A

empties into the posterior side of the right atrium
drains all of the blood that when to the heart muscle itself (specifically the myocardium)

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117
Q

pulmonary veins

A

veins from both lungs that enter into the left atrium
oxygen rich blood

118
Q

pulmonary arteries

A

coming out of the right ventricle and to the lungs
- sometimes known as the pulmonary trunk, that branches into right and left pulmonary arteries

119
Q

aorta

A

leaves the left ventricle and carries blood to the entire body

120
Q

human circulation

A

a two-circuit syste,
oxygen-rich blood is completely separated from oxygen-poor blood
-this is advantageous and makes the process more efficient

121
Q

two circuit system

A

each circuit has sites for gas exchange ca;;ed capillary beds
one capillary bed in the lungs where we pick up oxygen and leave waste
one capillary bed in the body tissue where we deliver oxygen

122
Q

pulmonary circuit

A

leaves the right side of the body
heart to lungs with oxygen poor blood

123
Q

systemic circuit

A

leaves the left side of the body
leaves the lungs and goes to the heart and right side of the body with oxygen rich blood
(collects waste from the body)

124
Q

coronary arteries

A

first branch off the myocardium that supplies blood to the heart muscle itself
-these arteries are generally the ones that get plugged with plaque

125
Q

cardiac veins

A

collect all the blood brought by the coronary arteries and return it to the heart chambers for reoxygenation

126
Q

coronary sinus

A

cardiac veins drain into this and then into the right atrium

127
Q

anastomoses

A

connection of blood vessels
allows blood to come from multiple sources so if one gets blocked, we still have blood supply

128
Q

atrioventricular valves

A

open when the pressure of blood in the atrium is higher than the pressure in the ventricles
prevents backflow of blood from ventricles to atria

129
Q

tricuspid valve

A

RIght atrioventricular valve
between the right atrium and right ventricle
3 cusps

130
Q

bicuspid (mitral) valve

A

Left atrioventricular valve
between the left atrium and left ventricle
2 cusps

131
Q

cordae tendinae

A

string-like structures that connect the flaps of the valves to the papillary muscles in the ventricles

132
Q

semilunar valves

A

located between the ventricles and their corresponding artery, and regulate the flow of blood leaving the heart

133
Q

aortic semilunar valve

A

between the left ventricle and aorta

134
Q

pulmonary semilunar valve

A

between the right ventricle and pulmonary artery

135
Q

what do valves regulate

A

the flow of blood through the heart by allowing pressure gradients to be established
-pressure is established due to the asynchronous contraction of the heart (lub dub)
-atria beat as a unit, then the ventricles beat as a unit while the atria relax

136
Q

cardiac muscles

A

has striations
uni-nucleated
functions through sliding filament action
connects exist between desmosomes and gap junctions (intercalated discs)
heart functions as a contractile unit

137
Q

intrinsic conduction

A

cardiac muscle doesn’t require a nervous impulse because the heart uses this method of conduction

138
Q

auto-rhythmic cells

A

non-contractile cells that are “leaky” and have unstable resting potentials
have a reduced permeability to potassium (sodium is still leaking in but potassium isn’t moving out)
causes the cells to depolarize (accumulate positive ion on the inside until reaching threshold)
at threshold, calcium channels open up and calcium floods into the cell and causes an action potential and leads to muscle contraction

139
Q

what causes msucle contraction in the heart

A

calcium!!! causes action potential
not sodium

140
Q

sinoatrial node

A

located at the very top of the heart (right atria; near where the coronary sinus empties)
spontaneously generates an action potential
known as the “pacemaker” of the heart

141
Q

atrioventricular node

A

located at the top of the right ventricle; right at the intersection of atria and ventricle; next to the interventricular septum
signal from SA node shotos down from here to the Bundle of His (towards the apex)

142
Q

Bundle of His

A

located in the middle of the heart
Branches into the left and right bundle branches (runs down the interventricular septum)

143
Q

bundle branches

A

travel down the heart from the bundle of his (between the ventricles)
transmits signal to the purkinje fibers

144
Q

purkinje fibers

A

located at the apex, runs up along the sides of the ventricles
delivers impulses to papillary muscles (this is why they contract before the rest of the ventricle)

145
Q

cardioaccelatory extrinsic innervation

A

sympathetic nervous impulses that increase heart rate through depolarization

146
Q

cardioinhibitory

A

parasympathetic nervous impulses that decrease heart rate through hyperpolarization

147
Q

electrocardiogram (ECG)

A

graphic recording of the electrical events of the heart
not mechanical, does not tell us if the heart is actively pumping blood

148
Q

p wave

A

depolarization of the atrium (time lag so that everything can move to the heart)

149
Q

QRS complex

A

depolaration of the ventricles and repolaration of the atria are both occuring BUT repolarization of atria is masked because the depolarization of ventricles is MUCH more electrically active

150
Q

what are the fatal irregular heart rhythms?

A

QRS complex
-if ventricles cannot pump, there is no oxygen going to the organs

151
Q

T wave

A

repolarization of teh ventricles

152
Q

what can an ECG show?

A

heart rate can be determined by pinking any particular portion of the ECG and determining the time between that point and the next point
-diagnose pathologies (fibrillations, location of heart attacks, etc) in the conduction system of the heart

153
Q

lub sound

A

S1
atrioventricular valves closing

154
Q

dub sound

A

S2
semilunar valves closing

155
Q

murmus

A

S3 and S4
backflow of blood due to a problem with a valve
-could be functional or non-functional

156
Q

cardiac cycle

A

one heart beat
Systole= contraction
Diastole= relaxation
We have interchanging systole and diastole of both atria, and systole and diastole of both ventricles
- contraction of atria when ventricles are relaxed and contraction of ventricles when atria are relaxed
as chambers contract, they create pressure which moves blood

157
Q

Average BP on left side of heart

A

120/80

158
Q

Average BP on right side of heart

A

24/8

159
Q

Why is blood pressure less on the left?

A

Less blood is being pumped (only going to lungs which is more delicate so there is less pressure)

160
Q

Cardiac output

A

Stroke volume multiplies by heart rate
- amount of blood that leaves the heart per minute

161
Q

Cardiac reserve

A

Amount of extra blood that can be pushed through the heart when we need it to be
-difference between amount at rest and the Mx amount possible
Average is between 20-25 liters

162
Q

Stroke volume

A

End systolic - end diastolic
-a mount of blood pushed out of the heart during each beat
-difference between the amount of blood in the ventricles before and after they contract (systole)

163
Q

Stretch of cardiac msucle and its affect on stroke volume

A

Pre-Load
-the more blood in the ventricles, the more stretch and the stronger the contraction
-causes ejection of more blood

164
Q

What is the stretch of cardiac muscle also called

A

Starling Law of the Heart

165
Q

Contraction strength affecting stroke volume

A

Neither pre or after-load
-muscle can change its permeability to calcium which causes increase in strength of contraction

166
Q

Arterial pressure

A

After-load
If there is increased pressure in the vessels, the heart can’t push blood out because it has to go from high pressure to low pressure

167
Q

What variable is cardiac output

A

It is a homeostatic variable
-our body likes to keep it pretty much the same
* if stroke volume increases for some reason, heart rate usually speeds up and if stroke volume decreases, heart rate usually slows down

168
Q

Parasympathetic nervous system affecting heart rate

A

Release ACh, which causes hyperpolarization of the sinoatrial node
Makes it harder to create a pacemaker potential because it slows it down

169
Q

Sympathetic nervous activation affecting heart rate

A

Releases norepinephrine, which causes the heart rate to increase
Changes activity at the sinoatrial node, so it depolarizes faster
Also causes an increase in the contractility of the muscle (contracts with more force)

170
Q

Adrenal medulla production of norepinephrine on heart rate

A

Releases a adrenaline (norepinephrine and epinephrine) as a hormone
Causes a short-lived increase in heart rate

171
Q

thyroxine on heart rate

A

thyroid gland produces thyroxine which increases cellular metabolic activity (which means a need for increased oxygen and more blood)
increased heart rate that lasts long

172
Q

BP changes on heart rate

A

detected by special receptors called baroreceptors (in our neck)
if BP goes up, less blood can get out of the heart so the heart needs to speed up to counteract that

173
Q

ionic balances on heart rate

A

ionic imbalances can speed up or slow down heart rate depending on what we have

174
Q

age on heart rate

A

heart rate (cardiac reserve) decreases as you age -> won’t be able to raise HR as high when exercising

175
Q

sex on heart rate

A

difference between genders
women have a faster HR than males

176
Q

exercise on heart rate

A

during exercise, your heart rate goes up (body needs more oxygen)
if you continue long term aerobic exercise, your resting HR will decrease

177
Q

temperature on heart rate

A

heart rate goes up when you have a fever (also when its hotter outside)

178
Q

vagal tone

A

vagus nerve slows down heart rate with the sympathetic nervous system
-without supervision, the sinoatrial node would keepo the heart beating at 100-110 bpm

179
Q

tachycardia

A

abnormally fast heart rate
greater than 10bpm

179
Q

vagal escape

A

the heart starts racing when it shouldn’t be
-issue with vagal tone

179
Q

bradycardia

A

abnormally slow heart rate
lower than 60bpm
if you’re an athlete, then this low is normal

180
Q

congestive heart failure

A

an umbrella term for anything that causes abnormally low cardiac output

181
Q

coronary atherosclerosis

A

coronary arteries get clogged from plaque deposits
stroke volume decreases, decreased amounts of oxygen delivered to the cardiac muscle –> can’t contract like it used to
leads to congestive heart failure

182
Q

high blood pressure (hypertension)

A

diastolic BP greater than 90
heart has to contract with more force to eject the blood, decreases stroke volume and cardiac output

183
Q

myocardial infarction

A

heart attack- oxygen supply to heart has been eliminated temporarily and the heart loses contractility permanently because lack of oxygen made it become fibrous connective tissue
-usually happens to coronary arteries!

183
Q

dilated cardiomyopathy

A

too much blood in the ventricles for an extended period of time
“flabby” ventrciles
usually because of too much stretch over time

184
Q

development of the heart

A

mesodermal origin
originates as two separate tubes of endothelial tissue that fuse together into a single chambered heart, 23 days post conception
by day 25, early stages of the 4 chambers start to form

185
Q

d-looping

A

the heart begins to flip upside down in the rightward direction
the heart will be in its final orientation at 46 days post conception

186
Q

foramen ovale

A

a hole in the fetus’ heart between the right and left atria through the interatrial septim
while in the womb, the embryo completes gas exchange via the mother so no blood needs to be sent to the lungs
provides shortcut that allows blood to bypass the pulmonary circuit
hole closes at birth and becomes fossa ovalis

187
Q

ductus arteriosus

A

a connection between the pulmonary trunk and the aorta which provides another shortcut in the embryo
blood that did not take the shortcut through the foramen ovale goes to right atrium and is pumped into the pulmonary trunk where it then goes through the connections to the aorta
blood that would be going to the lungs goes into the aorta instead and is distributed to the rest of the body

188
Q

ligmentum arteriosum

A

the ductus arteriosus seals and becomes this after birth

189
Q

valve sclerosis

A

age related change in heart function
deposits accumulate on top of the valve flaps, making them more rigid
the valves become less functional because it prevents them from closing all the way, so there is back flow of blood
decreased cardiac output (gradual process)

190
Q

decreased cardiac reserve

A

age-related change in heart function
as you age, you lose the ability to have a large cardiac reserve
this can be somewhat offset by exercise

191
Q

fibrosis of myocardium

A

if you fail to use the myocardium, it will begin to atrophy and become non-contractile
prevent this by staying active

192
Q

atherosclerosis

A

age related change in heart function
accumulation of plaque (typically cholesterol) along the inside of blood vessels
reduces diameter of blood vessels, which changes blood pressure
caused by high fat diet, cigarette smoking

193
Q

human circulatory system

A

we have a closed circulatory system
blood ALWAYS stays within the vessels

194
Q

arteries

A

carry blood away from the heart and generally carry oxygen rich blood (exception is the pulmonary arteries)

195
Q

elastic arteries

A

closer to the heart, larger in diameter
have low resistance
walls are rich in elastin (sheets of elastic connective tissue) which allows them to rebound and resist to maintain pressure in the blood
Ex. aorta or pulmonary artery

196
Q

muscular arteries

A

further from the heart and smaller in diameter
branch off the elastic arteries and carry blood to the organs
have some elasticity but not nearly as much; have smooth muscle in their walls

197
Q

arterioles

A

branches off of muscular arteries and lead to capillary beds

198
Q

capillaries

A

these are branches off arterioles
tiny, microscopic blood vessels that are one cell layer thick (simple squamous epithelial tissue)

199
Q

where is the site of gaseous exchange

A

in the capillaries
gases in the blood can diffuse out into interstitial space and gases in interstitial space can diffuse into the capillaries based on pressure differences

200
Q

venules

A

capillaries connect to these

201
Q

veins

A

venules connect to these
retrun blood back to the heart, carry oxyegn poor blood (EXCEPT pulmonary veins)
more blood here and lowest pressure here
valves assist blood returning to heart

202
Q

lumen

A

opening in the middle of the vessel that contains the blood

203
Q

tunica interna

A

inner lining of the vessel which surrounds the lumen
composed of simple squamous epithelium
cells bind to smooth, flat surface
*a continuation of the endocardium

204
Q

tunica media

A

deep to the tunica interna (middle layer)
consists of smooth muscle and elastin
really thick in arteries and less thick in veins

205
Q

how is blood vessel diameter controlled

A

controlled subconsciously through the sympathetic nervous system
these impulses cause vasoconstriction
absence of sympathetic nervous impulses allows vessels to dilate
chemicals like epinephrine from the adrenal medulla also cause constriction

206
Q

tunica externa

A

outermost layet that is made up of collagen and dense irregular conenctive tissue
anchors the blood vessels in place

207
Q

vasa vasorum

A

“blood vessels for blood vessels”
tiny little blood vessels that feed into the tunica externa and are only found in large blood vessels

208
Q

capillaries

A

microscopic blood vessels for gaseous exchange
small enough so each blood cell goes through single file (makes sure every cell gets oxygen and maximizes diffusion)
only have tunica interna layer (one layer makes gaseous exchange more efficient

209
Q

continuous capillaries

A

most common
epithelial cells, endothelium is very tightly joined together, have intercellular clefts, must go through walls for exchanges
located most places in the body (skin, muscles, etc)

210
Q

fenestrated capillaries

A

has pores called fenestrations that increase permeability across wall of capillary
located anywhere in the body that has high absorption and filtration rates
Ex. endocrine organs, small intestines, kidneys, digestive tract

211
Q

sinusoidal capillaries

A

have relatively large openings, leakiest type of capillary
large molecules/blood can pass through the walls
Located in liver (recycles old RBC) and bone (red bone marrow is site of blood cell production)

212
Q

capillary bed

A

allows capillaries to function as a network
microcirculation

213
Q

terminal arteriole

A

sends blood to capillary bed, can change blood flow by changing its diameter

214
Q

metarteriole

A

branches off from terminal arteriole

215
Q

thoroughfare channel

A

becomes post capillary venule, main middle channel

216
Q

postcapillary venule

A

thoroughfare channel empties into this and this returns blood to the vein

217
Q

vascular shunt

A

combination of metarteriole and thoroughfare channel
MUST ALWAYS BE OPEN

218
Q

true capillaries

A

branches off arterioles
where gas exchange occurs

219
Q

microcirculation

A

regulates the amount of blood going through the capillary beds

220
Q

pre capillary sphincters

A

right before each of the true capillaries, helps open or close individual capillaries
can be partially open to control the amount of blood passing through
–> regulates micro-circulation within the body

221
Q

artery vs veins: ARTERY

A

thick walls
small lumen
thick tunica media
low blood volume
high blood pressure
no valves

222
Q

artery vs veins: VEINS

A

thin walls
large lumen
thin tunica media
high blood volume
low blood pressure
venous valves

223
Q

varicose veins

A

sitting or standing for long periods of time causes the blood to pool and valves to weaken
valves begin to bulge in the veins

224
Q

muscular pump

A

helps get blood back to heart
blood vessels run next to skeletal muscle
when we contract muscles, they change shape and push against walls of the vessels which pushes blood up in the direction of the heart

225
Q

respiratory pump

A

helps get blood back to the heart
as we breathe, we have a change in the pressure of our thoracic cavity
as we inhale, blood can slip into the low pressure place close to the heart
this pulls it up to the heart

226
Q

collateral channels

A

multiple supply channels that connect to each other (connection is called anastomosis)
these go to places that need high blood supply
if one channel got blocked, there would still be a path for blood to get there

227
Q

blood flow

A

the amount of blood that is flowing in the body at any given time (always moves from high to low)
always takes the path of least resistance
flow throughout the system is relatively constant but the flow in a particular area is varied
-depends on need of that area (if an organ needs more blood, we dilate vessels going to it and constrict vessels going to other areas

228
Q

blood flow and BP

A

blood flow is directly proportional to differences in blood pressure
the greater the difference in pressure, the greater the amount of blood
flows from high to low pressure

229
Q

blood flow and peripheral resistance

A

blood flow is inversely proportional to peripheral resistance
due to friction
-flows more easily with less friction through a large vessel

230
Q

blood viscosity affecting peripheral resistance

A

change in slipperiness through the walls of the vessels
effects are individual; relatively constant because we can’t alter immediately
has a low effect

231
Q

vessel length affecting peripheral resistance

A

longer vessel is greater resistance (larger people have longer vessels)
-this causes effects between people but not individually
low effect (gradual as you grow)

232
Q

vessel diameter affecting peripheral resistance

A

larger diameter has less friction so it’s less resistant
arterioles change the most
determines blood flow
has largest effect- can change instantaneously

233
Q

systemic blood pressure

A

BP decreases continually as we move away from the heart
lowest pressure is found in veins that return blood to the heart
relatively high in the capillaries because it allows nutrient exchange to occur

234
Q

pulse pressure

A

systolic - diastolic pressure

235
Q

mean arterial pressure

A

pressure propelling blood to the tissues of the bodu- determines where blood goes

236
Q

MAP equation

A

MAP= diastolic pressure + (pulse pressure/3)
Ex. 120/90= 120-90= 30 90+ (30/3)= 90+10=100
-use diastolic because if your heart stopped pumping, you would still have diastolic pressure

237
Q

blood pressure control

A

requires integration of many different factors in the body

238
Q

alter blood distribution to respond to needs

A

counteracts a brief fluctuation in BP
-changes vessel diameter or closes the entire vessel
-can be local (single vessel) or systemic (all vessels constrict) changes

239
Q

alter vessel diameter

A

counteracts brief fluctuations in BP
dilation lowers pressure
constriction raises pressure
-in medulla oblongata, a collection of sympathetic fibers called vasomotor fibers attach to the vessels and cause vasoconstriction using norepinephrine

240
Q

vasomotor tone

A

blood vessels are always in a state of slight contraction

241
Q

neural reflex arc

A

baroreceptors are sensory receptors that monitor blood pressure
- they decide when it goes up or down

242
Q

when baroreceptor detects increase in BP

A
  1. baroreceptors are activated to start sending a signal to the brain
  2. this signal is transferred to the vasomotor center
  3. the vasomotor center is inhibited and this causes vessels to dilate.
  4. peripheral resistance is reduced and blood pressure goes down
243
Q

side effects of activating baroreceptors

A
  1. venus return reduced- amount of blood volume to heart is reduced and decreases cardiac output
  2. cardiac output reduced- less blood to be squeezed out of the heart which decreases stroke volume
  3. heart rate reduced- more time for heart to beat to maintain cardiac output
  4. contractile force reduced- less pressure on the walls and less contractile force
  5. MAP declines- decline in blood pressure due to less contraction
244
Q
A
245
Q

results of side effects of activating baroreceptors

A

Reduced MAP initiates vasoconstriction
- respond to low blood pressure by constricting in attempt to bring pressure back up
Increase cardiac output
-because heart rate slowed down in response to baroreceptor activation, this allows the heart to fill more before each contraction
Blood pressure rises

246
Q

chemical reflex arcs

A

chemoreceptors monitor the carbon dioxide concentration, oxygen concentration, and pH of blood
- they detect drop in oxygen level or pH, or increase in CO2

247
Q

if the chemoreceptors detect a decrease in oxygen, an increase in CO2, or a drop in pH

A
  1. a signal is sent by the chemoreceptor to stimulate the cardioacceleratory center
  2. this causes the heart rate to go up and the signal also goes to the vasomotor center
  3. the vasomotor center causes the blood vessels to constrict and blood pressure goes up. As BP increase and the heart beats faster, cardiac output increases
  4. increased cardiac output means more blood can go to the body, where it can pick up more oxygen and get rid of CO2.
248
Q

epinephrine and norepinephrine as a reflex arc

A

RAISES BP
released by the adrenal medulla
cause vasoconstriction and increased cardiac output during times of stress

249
Q

atrial natriuretic peptide (ANP) as a relfex arc

A

LOWERS BP
released by atria of the heart
vasodilation, increased urine production, decrease in blood volume due to water taken out of the blood

250
Q

Antidiuretic hormone (ADH) as a relfex arc

A

RAISES BP
released by the posterior pituitary
retains fluids and only causes vasoconstriction when extreme hemorrhage happens

251
Q

Angiotensin II as a reflex arc

A

RAISES BP
released by the liver
linked to resorption of blood and water via aldosterone production; causes vasoconstriction

252
Q

Endothelium-derived factors as a reflex arc

A

can eitehr raise or lower bp by constricting or dilating
released by lining of blood vessels
blood vessels release chemicals to change their own diameter

253
Q

inflammatory chemicals as a reflex arc

A

LOWERS BP
released by immune system
1. causes inflammation in response to damaged or infected tissue
2. increased permeability of circulatory system so things can leave easily

254
Q

Histamine effects on blood pressure

A

histamine in released during anaphylactic shock and causes a deadly crash in blood pressure

255
Q

alcohol as a reflex arc

A

LOWERS BP
1. inhibits ADH
2. inhibits vasomotor center (leads to vasodilation)
3. directly causes vasodilation

256
Q

nicotine as a relfex arc

A

Raises BP
functions exactly the same as epinephrine and norepinephrine

257
Q

what is the ONLY long-term mechanism of regulating blood pressure

A

renal regulation

258
Q

how does renal regulation work

A

alters blood volume, which changes blood pressure
lower blood volume=lower blood pressure
higher blood volume=higher blood pressure
*change in pressure causes kidneys to eliminate more water and produce more renin

259
Q

direct renal regulation mechanism

A

increase in blood pressure or blood volume speeds up filtration rate in the kidneys
blood DIRECTLY affects the kidneys
increased filtration rate increases blood volume, pressure, and amount of blood delivered by the arteries

260
Q

indirect renal mechanism

A

indirect- involves the liver
1. low blood pressure causes kidneys to release more renin and this stimulates angiotensin II production. this stimulates the adrenal medulla to produce aldosterone
2. aldosterone causes water to be reabsorbed and creates an osmotic gradient.
3. blood follows water back into the bloodstream and blood pressure increases

261
Q

pulse

A

as blood is circulationg, it creates waves of pressure and causes the feeling of pulse
-expansion and recoil of arteries

262
Q

blood pressure

A

related to the flow of blood pushing on the vessel wall
sphygmomanometer= BP cuff
1st Korotkoff sound= systolic
2nd Korotkoff sound= diastolic

263
Q

tissue perfusion

A

flow of blood is delivered to the body tissues based on need
as blood is flowing through tissue it delivers oxygen and nutrients and removes waste
as blood passes through the lungs it exchanges gas
as blood passes through the kidneys, it forms urine

264
Q

changes in tissue perfusion

A

during exercise:
we can increase cardiac output by dipping into our cardiac reserve
-do this by increasing heart rate, stroke volume, or both
-amount of blood going to brain remains relatively the same always, however, more blodo would go to skeletal muscle instead of the abdomen

265
Q

blood velocity

A

the rate at which blood is moving through out blood vessels
not constant; changes in different regions
blood moves fast in arteries and arterioles, very slow through capillaries, and speeds up again in venules and veins

266
Q

relationship between blood velocity and area of vessels

A

velocity is inversely related to the cross sectional area of the vessels
-capillaries have the greatest cross sectional area so blood passes through very slowly– increases efficiency of gaseous exchange

267
Q

how is velocity manipulated

A

blood velocity can be manipulated locally by changing the diameter of the arterioles
-if we dilate the arterioles, more blood goes through and travels faster
-if we constrict the arterioles, less blood goes through an it travels

268
Q

metabolic mechanism for regulating blood flow

A

low levels of oxygen or nutrients cause vasodilation, as well as relaxation of the pre-capillary sphincter so that blood will flow through them and more blood is delivered to that area

269
Q

myogenic mechanism for regulating blood flow

A

blood vessels respond to the stretch that is exerted on their walls
the more stretch, the more the vessel wants to push back, so it contracts
when blood pressure is high in a certain area, the blood vessel dilates and diverts is to go somewhere else

270
Q

angiogenic mechanism for regulating blood flow

A

production of new blood vessels
happens with people who train aerobically because more energy needs to go to the muscles
this is a training adaptation

271
Q

respiratory gases and lipid soluble molecules pass across the walls of blood vessels through…

A

simple diffusion

272
Q

water soluble solutes pass through walls of blood vessels through…

A

intercellular clefts and fenestrations

273
Q

larger molecules pass through walls of blood vessels through…

A

caveoli

274
Q

fluids pass through walls of blood vessels through…

A

pinocytic vesicles
through exocytosis or endocytosis

275
Q

capillary fluid dynamics

A

fluid is forced out through clefts at the arterial end of the capillary bed
-this movement is regulated by balance between hydrostatic pressure and colloid osmotic pressure
what is moved out at the arterial end comes back in the venous end

276
Q

hydrostatic pressure (fluid pressure)

A

the force exerted by a fluid against the thing that contains it
hydrostatic pressure in the capillaries IS blood pressure
capillary hydrostatic pressure is HIGHER on the arterial end, and LOWERS on the venous end due to loss of fluids (why fluid comes back in on venule end)

277
Q

colloid osmotic pressure

A

force created by non-diffusible components (mostly plasma proteins)
the pressure of the blood wants to force fluid out, buy the proteins in the blood want fluid to come back in via osmosis (water moves toward the more concentrated side)
functions in opposition to hydrostatic pressure

278
Q

four opposing forces that regulate movements in and out of the capillaries

A
  1. capillary hydrostatic – pushing out
  2. interstitial hydrostatic – pushing in
  3. capillary colloid osmotic– in blood, plasma proteins pull in
  4. interstitial colloid osmotic
279
Q

most important force that regulates movement in/out of capillaries

A

capillary hydrostatic pressure

280
Q

net filtration pressure

A

results from the interaction between hydrostatic and colloid osmotic pressures
determines if there is a net gain or loss of fluid from the capillaries

281
Q

portal systems

A

specialized capillary beds that exist between veins to the increase the amount of blood that we have
serves regional tissue needs

282
Q

most important portal system

A

hepatic portal system (liver)
this is needed because the liver has MANY important jobs

283
Q

hypovolemic shock

A

low blood volume due to bleeding that causes low blood pressure

284
Q

vascular shock

A

blood vessels are extremely dilated and causes low blood pressure

285
Q

cardiogenic shock

A

due to a failure of the heart pump
the heart is damaged and can no longer contract (MI)

286
Q

embryological development of the vessels

A

composed of simple squamous epithelium
heart lining continues tgrough the vessels
Mesodermal orgigin
1. mesodermal cells collect in isolated pockets called blood islands and they are distributed throughout the embryo
2. the blood islands connect to form vascular tubes and secrete platelet derived growth factor. This signals mesenchymal cells to form muscular and fibrous coats

287
Q

atherosclerosis

A

deposits of plaque (usually cholesterol) that accumulate on the walls of the vessels
-they reduce the size of the vessels, which reduces the space for blood flow

288
Q

who is less likely to suffer from atherosclerosis

A

females are less likely then men
-estrogen helps break down cholesterol so plaque deposits don’t build up

289
Q

hypertension

A

long-term high blood pressure
-tiny vessels in brain can open (stroke)
-capillaries can burst in eyes (blindness)
-heart attacks
-kidney disease
-heart failure
-sexual dysfunction

BIOL 2230 (3 decks)

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